Mitochondrial Inhibitors and Neurodegenerative Disorders
Mihondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mihondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mihondrial electron transport system. Consistent with their ancestry, the mihondria have their own DNA that encodes many but not all of their proteins. The mihon dria and their genes come from the mother via the ovum since sperm do not possess mihondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mihondrial gene mutations might be a source of human dis ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes.
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Mitochondrial Inhibitors and Neurodegenerative Disorders
Mihondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mihondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mihondrial electron transport system. Consistent with their ancestry, the mihondria have their own DNA that encodes many but not all of their proteins. The mihon dria and their genes come from the mother via the ovum since sperm do not possess mihondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mihondrial gene mutations might be a source of human dis ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes.
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Mitochondrial Inhibitors and Neurodegenerative Disorders
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Mitochondrial Inhibitors and Neurodegenerative Disorders
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Product Details
| ISBN-13: | 9780896038059 |
|---|---|
| Publisher: | Springer-Verlag New York, LLC |
| Publication date: | 10/01/1999 |
| Series: | Contemporary Neuroscience |
| Edition description: | 2000 |
| Pages: | 314 |
| Product dimensions: | 6.10(w) x 9.25(h) x 0.03(d) |
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