Molecular Aspects of Host-Pathogen Interactions / Edition 1

by M. A. McCrae, J. R. Saunders, C. J. Smyth, N. D. Stow

Overview

An understanding of the relationship between a pathogen and its host is essential for the development of effective disease control measures. This volume focuses on interactions at the molecular level, specifically between the proteins of the infectious agent and the host that has been invaded. Both viral and bacterial systems are considered, with specific examples illustrating the rapid advances being made in defining the molecular mechanisms underlying infection.

Product Details

ISBN-13:	9780521592154
Publisher:	Cambridge University Press
Publication date:	05/13/1997
Series:	Society for General Microbiology Symposia , #55
Edition description:	New Edition
Pages:	373
Product dimensions:	6.20(w) x 9.20(h) x 1.00(d)

About the Author

McCrae, M. A. ; Saunders, J. R.; Smyth, C. J.; Stow, N. D.

The contributors represent the specialties of microbiology, molecular biology, biochemistry, cell biology, and pathology. Most are from universities and research institutes in the U.S., the U.K., Belgium, Germany, Canada, France, and Republic of Ireland. Institutions prominently represented include Laboratory of Molecular Biology-Cambridge, Univ of Dublin, Institut Pasteur, SUNY at Stony Brook, and Mount Sinai School of Medicine.

Table of Contents

1. Overview C. Chothia; 2. Picornavirus receptors, tropism and pathogenesis D. J. Evans; 3. Cross-talk between Yersinia and eukaryotic cells G. R. Cornelis; 4. Host-pathogen protein-protein interactions in Staphylococcus T. J. Foster, O. Hartford and D. O'Connell; 5. Mechanisms of microbial adhesion: the paradigm of Neisseriae M. Virji; 6. Virus-host interactions in the control of the gene expression of nuclear replicating DNA viruses R. D. Everett; 7. Regulation of human immunodeficiency virus gene expression Tat J. Karn, N. J. Keen, M. J. Churcher, F Aboul-Ela, G. Varani and M. J. Gait; 8. Chlamydia host and host cell interactions M. Ward; 9. Control of the fimbrial expression by a random genetic switch in Escherichia coli C. J. Dorman, N. C. Nolan and S. G. J. Smith; 10. Virus and the protein synthesis machinery of the cell: Offense, defense and dependence M. B. Matthews; 11. Shigella-induced cytoskeletal reorganisation during host cell invasion G. Tran Van Nhieu, T. Adams, C. Dehio, R. Ménard, A. Skoudy, J. Mounier, R. Hellio, P. Gounon and P. Sansonetti; 12. Transport through plasmodesmata and nuclear pores: cell-to-cell movement of plant viruses and nuclear import of Agrobacterium T-DNA R. Lartey, S. Ghoshroy, J. Sheng and V. Citovsky; 13. Viral cell recognition and entry M. Rossman; 14. Enteropathogenic Escherichia coli and Salmonella species: exploitation of host cells? B. Finlay; 15. Host-viral protein-protein in influenza virus replication P. Palese, P. Wang, T. Wolff and R E O'Neill; 16. Transmissible spongiform encephalopathies and the formation of protease-resistant prion protein B. Caughey; Index.

Editorial Reviews

Reviewer: Charles E. Edmiston, Jr., PhD (Medical College of Wisconsin)
Description: This is a state-of-the-art review of the mechanisms of microbial-host interactions, emphasizing those protein interactions that mediate adherence and invasion. The various chapters are written by well-known investigators who participated in a 1997 symposium on host-pathogen interactions sanctioned by the Society for General Microbiology.
Purpose: This book is intended to be a review of recognized mechanisms of protein-protein interactions that occur with both bacteria and viruses during infection.
Audience: The book is appropriate as a review source on the subject of microbial pathogenesis. Medical microbiologists, physicians conducting research in this area, and graduate students would benefit from reviewing this material.
Features: The topic covered in the book is the microbial pathogenesis of bacteria and viruses with a specific focus on the genetics and physiochemical dynamics of cellular adherence and invasion. The book is written in a clear style with numerous citations and illustrations.
Assessment: Although the book would be of most benefit to those individuals who are currently conducting research in this area, it has an obviously broader appeal as a review for any student or practitioner interested in microbial pathogenesis or medical microbiology. The numerous contributing authors are well regarded within their respective fields and enhance the overall value of the text. This would be a valuable addition to any university or departmental library collection of medical microbiology textbooks.

Doody's Review Service

"The book is written in a clear style with numerous citations and illustrations...the numerous contributing authors are well regarded within their respective fields and enhance the overall value of the text." Doody's Health Sciences Book Review Journal

"...the volume illustrates the rapid advances being made in defining the molecular mechanisms in microbial pathogenesis. It will be useful to graduate students and researchers in the field of host-pathogen interactions and is highly recommended for purchase by medical libraries as a reference source." Canadian Society of Microbiologists Newsletter

From the Publisher

2 Stars from Doody

This is a state-of-the-art review of the mechanisms of microbial-host interactions, emphasizing those protein interactions that mediate adherence and invasion. The various chapters are written by well-known investigators who participated in a 1997 symposium on host-pathogen interactions sanctioned by the Society for General Microbiology. This book is intended to be a review of recognized mechanisms of protein-protein interactions that occur with both bacteria and viruses during infection. The book is appropriate as a review source on the subject of microbial pathogenesis. Medical microbiologists, physicians conducting research in this area, and graduate students would benefit from reviewing this material. The topic covered in the book is the microbial pathogenesis of bacteria and viruses with a specific focus on the genetics and physiochemical dynamics of cellular adherence and invasion. The book is written in a clear style with numerous citations and illustrations. Although the book would be of most benefit to those individuals who are currently conducting research in this area, it has an obviously broader appeal as a review for any student or practitioner interested in microbial pathogenesis or medical microbiology. The numerous contributing authors are well regarded within their respective fields and enhance the overall value of the text. This would be a valuable addition to any university or departmental library collection of medical microbiology textbooks.

Charles E. Edmiston