Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice / Edition 4

by Sumner J. Yaffe MD, Jacob V. Aranda MD, PhD, FRCP(C)

Overview

Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.

The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.

Product Details

ISBN-13:	9780781795388
Publisher:	LWW
Publication date:	10/12/2010
Edition description:	Fourth
Pages:	1072
Product dimensions:	8.60(w) x 11.20(h) x 1.70(d)

Table of Contents

I: GENERAL PRINCIPLES"

1: Introduction and Historical Perspectives

2: Clinical Pharmacokinetics in Infants and Children

3: Drug Action and Therapy in the Infant and Child

4: Drug Metabolism and Disposition in Infants and Children

5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics

6: Compliance with Pediatric Medication Regimens

7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations

8: Ethics of Drug Research in Pediatric Populations

9: Therapeutic Drug Monitoring

10: Drug Formulations

II: DRUGS AND THE NEWBORN

11: Developmental Toxicology

12: Biotransformation of Medications by Human Placenta

13: Maternal Drug Intake and the Newborn

14: Principles of Neonatal Pharmacology

15: Perinatal Origins of Adult Defects in Drug Metabolism

16: Renal Function and Excretion of Drugs in the Newborn

17: The Excretion of Drugs and Chemicals in Human Milk

18: Drugs for Hyperbilirubinemia

19: Drugs and Lung Development

20: Pharmacologic Treatment of Neonatal Apnea

21: Drugs and Perinatal Brain Injury

22: Antiretroviral Pharmacology in Pregnant Women and Newborns

III: DRUGS IN SPECIAL POPULATIONS AND SETTINGS

23: Therapeutic Applications in Pediatric Intensive Care

24: Drug Therapy in the Pediatric Emergency Department

25: Drug Therapy in the Adolescent

26: Topical Medications

27: Ophthalmologic Drugs in Infants and Children

IV: SPECIFIC DRUGS

28: Sulfonamides

29: Penicillins, Cephalosporins, and Other Beta-Lactams

30: Aminoglycosides and Glycopeptides

31: Fluoroquinolones

32: Macrolides, Chloramphenicol, and Tetracyclines

33: Anthelminthic Drugs in Children

34: Antituberculosis Drugs

35: Antifungal Agents

36: Antiviral Drugs: Treatment of the Fetus and Newborn

37: Anticonvulsants

38: Psychopharmacology in Children and Adolescents

39: Antihistamine Drugs

40: Antiasthmatics

41: Antipyretics

42: Cardiovascular Drugs

43: Diuretics

44: Clinical Pharmacology of Antineoplastic Drugs

45: Immunosuppressive and Immunomodulatory Drugs

46: Analgesic Agents

47: Local Anesthetics for Infants and Children

48: Nonsteroidal Anti-inflammatory Drugs

49: Antihypertensive Agents

50: Gastrointestinal Drugs

51: Glucocorticoids

52: Insulin and Diabetes Mellitus

53: Thyroid Hormones

54: Growth Hormone

55: Hematologic Agents

56: Nutrient Supplements

57: Childhood Vaccines

V: ADVERSE DRUG EFFECTS AND INTERACTIONS

58: Epidemiology of Adverse Drug Effects

59: Mechanisms of Adverse Drug Reactions

60: Medication Errors

61: Pediatric Poisonings and Antidotes

62: Use of Herbal Products in Children: Risks and Unproven Benefits

63: Neonatal Abstinence Syndromes

64: Drug Interactions in Newborns and Children

VI: APPENDIX

65: Drug Formulary for the Newborn

66: Pediatric Drug Formulary

Editorial Reviews

Reviewer: Jay P. Goldsmith, MD (Tulane University School of Medicine)
Description: This is the fourth edition of the book that has become the gold standard in pediatric pharmacology. It covers all aspects of pediatric pharmacology, including molecular and physiologic principles of pharmacokinetics and guidelines for drug therapy, and devotes chapters to specific classes of drugs, specific settings such as the NICU and emergency room, specific aspects of drug use such as medication errors, drug monitoring, and adherence to medication regimens, and the ethics of drug research on children. The previous edition was published in 2005.
Purpose: It is intended to be a comprehensive, authoritative reference in pediatric pharmacology with updated and evidence-based information for clinicians as well as scientists in this area. In this rapidly changing field, this is a worthy objective which the authors and contributors have fully met.
Audience: The audience consists of pediatric and neonatal practitioners at all levels of training or clinical responsibility. The book is more comprehensive than a drug formulary and gives much more information than just drug doses and routes of administration. Pharmacologists and researchers in this area will also find this book invaluable. The authors and contributors are world-renowned authorities in this field.
Features: The book is quite comprehensive, beginning with a section on general principles. Other sections cover drugs for special populations (including a whole section on newborns), specific drugs by class or for certain conditions, and adverse drug effects and interactions. Many of the chapters include very up-to-date discussions on pharmacokinetics, pharmacodynamics, and pharmacogenomics. Special chapters on the ethics of drug research in children, medication errors, and adherence to medication regimens are unique to this book. Two extensive appendixes cover neonatal and pediatric drug formularies. I would have preferred the addition of nursing input in some chapters, such as the ones on therapeutic compliance and safety issues.
Assessment: This is truly the gold standard of pediatric and neonatal pharmacology. It is much more extensive than the standard pediatric drug formulary handbooks and its size (1,042 pages) means it is designed to be a reference in the office and not carried in one's lab coat pocket. However, it is a must-have reference for every pediatric ward and specialty unit since drug therapy is so essential and often misunderstood and misused.

Doody's Review Service

"This is truly the gold standard of pediatric and neonatal pharmacology. It is much more extensive than the standard pediatric drug formulary handbooks and its size means it is designed to be a reference in the office and not carried in one's lab coat pocket. However, it is a must-have reference for every pediatric ward and specialty unit since drug therapy is so essential and often misunderstood and misused."

Weighted Numerical Score: 98 - 5 Stars!

Doody Enterprises, Inc. book review, February 2011


"Neonatal and Pediatric Pharmacology is a well-presented, comprehensive resource covering basic pediatric pharmacology and the therapeutic principles that underlie the use of medications in newborns and children. It will be a helpful reference for all practitioners who care for children and invaluable for those who conduct research or teach."

John L. Zeller, MD, PhD, Contributing Editor, Journal of the American Medical Association

From the Publisher