Neurodevelopment and Adult Psychopathology / Edition 1

by Matcheri S. Keshavan, Robin M. Murray, David Kupfer

Overview

This is an important book on the role of neurodevelopmental factors in the pathogenesis of the major psychiatric disorders. An international group of experts, including many of those responsible for the ideas that have come to dominate current thinking, reviews the fields of developmental neurobiology, clinical psychiatry, and behavioral neuroscience. The first section, "The Developing Brain", reviews neurodevelopment from the molecular to the behavioral level. Section Two, "Development and Psychopathology", covers clinical applications of the basic principles of developmental neurobiology. The third and final section, "Integrative Models", presents approaches toward a synthesis of neurodevelopmental and clinical findings in psychiatric disorder.

Product Details

ISBN-13:	9780521485654
Publisher:	Cambridge University Press
Publication date:	09/11/1997
Edition description:	New Edition
Pages:	300
Product dimensions:	7.44(w) x 9.69(h) x 0.63(d)

About the Author

Keshavan, Matcheri S., MD, MRCPsych (Univ of Pittsburgh); Murray, Robin M., FRCPsych, DSc (King's Coll School of Medicine and Dentistry, London)

The contributors represent the specialties of psychological medicine, psychiatry and behavorial sciences, neurology, and neuroscience. Most come from universities and research institutes in the U.S., the U.K., Australia, and Canada. Institutions prominently represented include Institute of Psychiatry and Kings College, Western Psychiatric Institute and Clinic-Univ of Pittsburgh, UCSD, and Clark Institute of Psychiatry.

Table of Contents

Part I. The Developing Brain: 1. Development of the cerebral cortex: an overview Jennifer S. Lund; 2. Development of the primate prefrontal cortex David A. Lewis; 3. The genetics of neurodevelopment and schizophrenia Astride M. Vicente and James L. Kennedy; 4. Glutamate receptors and development anomaly in medial temporal lobe in schizophrenia Robert W. Kerwin et al.; 5. MRI studies of developing brain Terry Jernigan and Elizabeth R. Sowell; 6.31P magnetic resonance spectroscopy studies of developing brain Jay W. Pettegrew et al.; 7. PET studies of developing brain Harry T. Chugani and Diane C. Chugani; 8. Long term effects of different early rearing experiences on social, emotional, and physiological development in nonhuman primates Stephen J. Suomi; Part II. Development and Psychopathology: 9. From birth to onset: a developmental perspective of schizophrenia in two national birth cohorts Peter Jones and D. John Done; 10. Developmental aspects of schizophrenia Michael F. Pogue-Geile; 11. Sex differences in schizophrenia Gretchen L. Haas and David J. Castle; 12. Psychopathology and brain dysfunction: structural imaging studies Shon Lewis; 13. Neuropathology, neurodevelopment, and schizophrenia Kathryn J. Kotrla et al.; 14. Neurodevelopmental models of affective disorders Henry A. Nasrallah; 15. Heterogeneity within obsessive compulsive disorder evidence for primary and neurodevelopmental subtypes Tom Blanes and Philip McGuire; 16. Schizophrenia: a critique from the devlopmental psychopathology perspectives Chris Hollis and Eric Taylor; Part III. Integrative Models: 17. Schizophrenia as an emergent disorder of late brain maturation Irwin Feinberg; 18. Schizophrenia as a developmental disorder of neural network integrity: the dysplastic net hypothesis Ed T. Bullmore et al.; 19. Neurodevelopment and schizophrenia: quo vadis? Matcheri S. Keshavan.

Editorial Reviews

Reviewer: Michael Schrift, DO (University of Washington School of Medicine)
Description: This exciting new book covers the emerging relationship between abnormalities of central nervous system development and adult psychopathological states. The book is an outgrowth of recent findings in neuroscience relating specific abnormalities noted in the developing fetal brain to risk factors for adult onset schizophrenia. Written and edited by internationally recognized experts in this area, this book is a valuable contribution to the field.
Purpose: The purpose of the book, according to the editors, is to present to the reader the rapidly expanding knowledge base in developmental biology, and its consequences for our understanding of major adult psychiatric disorders. The editors have succeeded in producing a readable and comprehensive review of this extremely important research.
Audience: The intended audience, according to the editors, is researchers in the fields of behavioral neuroscience, developmental biology, and biological psychiatry. It would also be informative to clinicians and trainees who want to keep abreast of this important emerging research.
Features: The book features 282 pages divided into three sections and 19 chapters. Section I is a review of normal neural development. Section II covers research findings relevant to adult onset psychiatric disorders such as schizophrenia, autism, affective disorders, and obsessive-compulsive disorder. Section III focuses on integrating various neurodevelopmental models of schizophrenia. Each chapter is referenced with up-to-date citations and there is a useful index at the back of the book.
Assessment: This is an outstanding new book on the relationship between early developmental brain abnormalities and adult psychopathological states, integrating basic and clinical neurosciences. It is a welcome contribution to the field and will be useful as a reference for researchers and clinicians in psychiatry.

Doody's Review Service

"This is an outstanding new book on the relationship between early developmental brain abnormalities and adult psychopathological states, integrating basic and clinical neurosciences. It is a welcome contribution to the field and will be useful as a reference for researchers and clinicians in psychiatry." Doody's Journal, Michael J. Schrift, DO

"Taken as a whole, the authors collectively make a strong statement for the necessary integration of basic and clinical neurosciences, in understanding the emergence of psychopathology." Ricardo Berjano, MD; Neurological Research

From the Publisher

4 Stars! from Doody

This exciting new book covers the emerging relationship between abnormalities of central nervous system development and adult psychopathological states. The book is an outgrowth of recent findings in neuroscience relating specific abnormalities noted in the developing fetal brain to risk factors for adult onset schizophrenia. Written and edited by internationally recognized experts in this area, this book is a valuable contribution to the field. The purpose of the book, according to the editors, is to present to the reader the rapidly expanding knowledge base in developmental biology, and its consequences for our understanding of major adult psychiatric disorders. The editors have succeeded in producing a readable and comprehensive review of this extremely important research. The intended audience, according to the editors, is researchers in the fields of behavioral neuroscience, developmental biology, and biological psychiatry. It would also be informative to clinicians and trainees who want to keep abreast of this important emerging research. The book features 282 pages divided into three sections and nineteen chapters. Section I is a review of normal neural development. Section II covers research findings relevant to adult onset psychiatric disorders such as schizophrenia, autism, affective disorders, and obsessive-compulsive disorder. Section III focuses on integrating various neurodevelopmental models of schizophrenia. Each chapter is referenced with up-to-date citations and there is a useful index at the back of the book. This is an outstanding new book on the relationship between early developmental brain abnormalities and adult psychopathological states, integrating basicand clinical neurosciences. It is a welcome contribution to the field and will be useful as a reference for researchers and clinicians in psychiatry.

Michael J. Schrift