Nitric Oxide and the Regulation of the Peripheral Circulation

by Philip J. Kadowitz (Editor), Dennis B. McNamara (Editor), P. Kadowitz

Overview

Nitric Oxide in the Regulation of Blood Flow: A Historical Overview.- 1. Nitric Oxide in the Regulation of Blood Flow: A Historical Overview.- I: Selected Mechanisms Of Action.- 2. Regulation of Intracellular Ca2+ by Cyclic GMP-Dependent Protein Kinase in Vascular Smooth Muscle Cells.- 3. Oxidants and Vascular Nitric Oxide Signaling.- 4. Role of Na+-K+-ATPase in Nitric Oxide-Induced Relaxation.- 5. Purinergic Receptors, Nitric Oxide, and Regional Blood Flow.- 6. Nitric Oxide Derived from Perivascular Nerves and Endothelium.- 7. Nitric Oxide and Hypertension.- II: Vascular Bed.- A. Cerebral.- 8. Nitric Oxide in Control of the Cerebral Circulation.- B. Pulmonary.- 9. Intravenous Anesthetics in the Pulmonary Circulation.- 10. Inhaled Nitric Oxide Therapy for Acute Respiratory Failure.- 11. Clinical Applications of Inhaled Nitric Oxide.- 12. Nitric Oxide and the Perinatal Pulmonary Circulation.- C. Skeletal.- 13. Nitric Oxide and the Pulmonary Circulation in the Adult.- 14. Role of Nitric Oxide in the Skeletal Muscle Vascular Bed.- D. GI/GU.- 15. Nitric Oxide and the Hepatic Circulation.- 16. Nitric Oxide and the Gastrointestinal Circulation.- 17. Uterine Effects of Nitric Oxide.- 18. NO Effect on Penile Blood Flow and Lower Genitourinary Tract Function.- 19. Role of Nitric Oxide in the Regulation of Renal Blood Flow.- E. Renal.- 20. Role of Nitric Oxide in the Regulation of Renal Function in Conscious Animals.- 21. Modulation of Renal Micro vascular Responsiveness by Nitric Oxide.

Product Details

ISBN-13:	9780817640460
Publisher:	Birkhauser Verlag
Publication date:	12/28/1999
Series:	Nitric Oxide in Biology and Medicine Series , #1
Edition description:	New Edition
Pages:	372
Product dimensions:	6.30(w) x 9.45(h) x (d)

Table of Contents

1. NO in the Regulation of Blood Flow: A Historical Overview; 2.
Regulation of Intracellular Ca2+ by Cyclic GMP-Dependent Protein Kinase in Vascular Smooth Muscle Cells; 3. Oxidants and Vascular NO Signaling; 4. Role of Na+-K+-ATPase in NO-Induced Relaxation; 5.
Purinergic Receptors, NO and Regional Blood Flow; 6. NO Derived from Perivascular Nerve and Endothelium; 7. NO & Hypertension; 8. NO in Control of the Cerebral Circulation; 9. Intravenous Anesthetics in the Pulmonary Circulation; 10. Inhaled NO Therapy for Acute Respiratory Failure; 11. Clinical Applications of Inhaled NO; 12. NO and the Perinatal Pulmonary Circulation; 13. NO and the Pulmonary Circulation in the Adult; 14. Role of NO in the Skeletal Muscle Vascular Bed; 15.
NO and Hepatic Circulation; 16. NO and the Gastrointestinal Circulation; 17. Uterine Effects of NO; 18. NO Effect on Penile Blood Flow and Lower Genitourinary Tract Function; 19. Role of NO in the Regulation of Renal Blood Flow; 20. Role of NO in the Regulation of Renal Function in Conscious Animals; 21. Modulation of Renal Microvascular Responsiveness by NO.

Editorial Reviews

This is a broad summary of the last 20 years concerning the discovery and science of the vasoactive substance nitric oxide (NO). There are more than 40 contributors to this book, including the recent Nobel Laureate Lou Ignarro. The editors attempt to summarize the current state of knowledge of the mechanisms of NO's effect in the vasculature. The purpose is to provide a comprehensive review of the molecule NO, from its discovery as the "mysterious" endothelial derived relaxation factor to its broad based mechanisms of action. This book is oriented toward biomedical scientists. The main objective is to assist investigators and professors in a more thorough understanding of NO and its biological activity. Each chapter is designed as a state-of-the-art review of the synthesis and measurement of NO and its biochemistry and physiology. Additional information on the molecular biology of NO synthase is also provided. This book is quite simply an outstanding review on the biology of NO. Dr. Ignarro gives an excellent overview of the discovery of NO and how this discovery has assisted in our understanding of the mechanism of action of numerous cardiovascular vasodilators. The data presented in each chapter are first rate and clearly illustrated. The conclusions on mechanism of action of NO are consistent with the data. I personally will use this valuable reference in preparation of didactic materials in cardiovascular pharmacology.

John Buchholz