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Overview
methodical analysis. Additionally, thoughtfully presented diagrams and infographics can convey
a large amount of complex information in a more intuitive and accessible manner. 100 Must-Know
Mechanisms (Second Edition) strives to be at the intersection of these two key principles. Its
thorough visualizations enable experienced readers to use it as a quick reference for specific
mechanisms of interest. At the same time, the book’s breadth of covered reactions, from classic to
cutting-edge, make it a good study-aid for the developing chemist. A slow and consistent study of
the entire series of mechanisms can help set the foundation for good scientific intuition, while its
detailed infographics and careful navigation features encourage coming back to it frequently. This
edition includes over 40 new illustrations, numerous new mechanistic schemes, enhanced original
figures with a variety of real-case examples, and more
Product Details
| ISBN-13: | 9783110786828 |
|---|---|
| Publisher: | De Gruyter |
| Publication date: | 07/04/2023 |
| Series: | De Gruyter Textbook |
| Edition description: | 2nd, Completely Revised Edition |
| Pages: | 289 |
| Product dimensions: | 6.69(w) x 9.45(h) x (d) |
| Age Range: | 18 Years |
About the Author
University- MSU (Russia, Moscow). MSU is one of the oldest established and most competitive
universities in the country. He then moved across the ocean to the United States where he earned
a Ph.D. in Organic Chemistry at the University of Denver. Afterward, he completed two
postdoctoral fellowships, one with Professor K. C. Nicolaou at the Scripps Research Institute in
La Jolla, California, and another with Professor M. G. Finn at the Georgia Institute of Technology
in Atlanta, Georgia. His industrial career started in Boston, Massachusetts where he joined the
formulation development group in a medium-sized biopharmaceutical company. He gained
experience in drug development and early discovery with an emphasis on physical organic
chemistry, nuclear magnetic resonance (NMR), formulation development techniques, and
materials science before joining the medicinal chemistry group as a synthetic chemist. After six
years working in a biotech hub on the East Coast, he continues his career path as an organic chemist
in San Diego.
In the course of his career, he has published over twenty research and review articles and is a coinventor on numerous patents. As a Ph.D. scientist, he believes in staying engaged with the
learning community, and draws inspiration through teaching and by making visually-engaging and
educational chemistry infographics, which he shares on The ChemInfoGraphic Blog:
www.cheminfographic.com/
Dr. Valiulin’s scientific research focuses on chemical synthesis and includes collaboration with
researchers who are driven by a passion to deliver novel chemical compounds that may help save
lives
Table of Contents
Preface and Overview vii
List of Acronyms and Abbreviations 6
1 Electrophilic Addition Mechanism 10
2 Nucleophilic Substitution Mechanism 12
3 Aromatic Electrophilic Substitution Mechanism 14
4 Aromatic Nucleophilic Substitution Mechanism 16
5 Aromatic Radical Nucleophilic Substitution Mechanism 18
6 Elimination Mechanism 22
7 Acyloin Condensation 26
8 Alkyne Zipper Reaction 28
9 Arbuzov Reaction 30
10 Arndt-Eistert Synthesis 32
11 Baeyer-Villiger Oxidation 34
12 Barton Decarboxylation 36
13 Baylis-Hillman Reaction 38
14 Beckmann Rearrangement 40
15 Benzoin Condensation 42
16 Benzyne Mechanism 44
17 Bergman Cyclization 46
18 Birch Reduction 48
19 Bischler-Napieralski Cydization 50
20 Brown Hydroboration 52
21 Buchwald-Hartwig Cross Coupling 54
22 Cannizzaro Reaction 56
23 Chan-Evans-Lam Cross Coupling 58
24 Chichibabin Amination 60
25 Claisen Condensation 62
26 Claisen Rearrangement 64
27 Cope Elimination 66
28 Cope Rearrangement 68
29 Criegee & Malaprade Oxidation 70
30 CuAAC 72
31 Curtius Rearrangement 74
32 Oarzens Condensation 78
33 Dess-Martin Oxidation 80
34 Diazotization (Diazonium Salt) 82
35 Diels-Alder Cycloaddition 84
36 Di-π-Methane Rearrangement 86
37 Favorskii Rearrangement 88
38 Fischer Indole Synthesis 90
39 Friedel-Crafts Acylation & Alkylation 92
40 Gabriel Synthesis 94
41 Gewald Reaction 96
42 Glaser-Eglinton-Hay Coupling 98
43 Grignard Reaction 100
44 Grob Fragmentation 102
45 Haloform Reaction 104
46 Heck Cross Coupling 106
47 Hell-Volhard-Zelinsky Reaction 108
48 Hiyama Cross Coupling 110
49 Hofmann Elimination 112
50 Horner-Wadsworth-Emmons Olefination 114
51 Jones Oxidation 116
52 Kucherov Reaction 118
53 Kumada Cross Coupling 120
54 Ley-Griffith Oxidation 122
55 Liebeskind-Srogl Cross Coupling 124
56 Mannich Reaction 126
57 McMurry Coupling 128
58 Meerwein-Ponndorf-Verley Reduction 130
59 Michael Addition 132
60 Minisci Reaction 134
61 Mitsunobu Reaction 136
62 Miyaura Borylation 138
63 Mukaiyama RedOx Hydration 140
64 Nazarov Cyclization 142
65 Nef Reaction 144
66 Negishi Cross Coupling 146
67 Norrish Type I & II Reaction 148
68 Olefin (Alkene) Metathesis 150
69 Oppenauer Oxidation 154
70 Ozonolysis 156
71 Paal-Knorr Syntheses 158
72 Paternò-Büchi Reaction 162
73 Pauson-Khand Reaction 164
74 Peptide (Amide) Coupling 166
75 Pictet-Spengler Reaction 170
76 Pinacol-Pinacolone Rearrangement 172
77 Polonovski Reaction 174
78 Prilezhaev Epoxidation 176
79 Prins Reaction 178
80 Pummerer Rearrangement 180
81 Ramberg-Bäcklund Rearrangement 182
82 Reformatsky Reaction 184
83 Robinson Annulation 186
84 Shapiro Reaction 188
85 Sonogashira Cross Coupling 190
86 Staudinger Reaction 192
87 Steglich Esterifkation 194
88 Stille Cross Coupling 196
89 Suzuki Cross Coupling 198
90 Swern Oxidation 200
91 Ugi Reaction 202
92 Ullmann Aryl-Aryl Coupling 204
93 Upjohn Dihydroxylation 206
94 Vilsmeier-Haack Reaction 208
95 Wacker Oxidation 210
96 Wagner-Meerwein Rearrangement 212
97 Weinreb Ketone Synthesis 214
98 Wittig Reaction 216
99 Wohl-Ziegler Reaction 218
100 Wolff-Kishner Reduction 220
Acknowledgments 223
Bibliography and References 225