Pharmacogenomics in Drug Discovery and Development / Edition 1

by Qing Yan

Overview

This comprehensive volume explores cutting-edge technologies used to pursue systems-based pharmacogenomics. Extensive chapters follow on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.

Product Details

ISBN-13:	9781617378256
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/19/2010
Series:	Methods in Molecular Biology , #448
Edition description:	Softcover reprint of hardcover 1st ed. 2008
Pages:	487
Product dimensions:	6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Table of Contents

1. The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery

Qing Yan

2. Applications of Microarrays and Biochips in Pharmacogenomics

Gary Hardiman

3. Confounding in Genetic Association Studies and Its Solutions

Donglei Hu and Elad Ziv

4. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches

Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg

5. Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy

Tessa M. Bosch

6. Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease

Miles D. Thompson, David E.C. Cole and Pedro A. Jose

7. G Protein-coupled Receptors Disrupted in Human Genetic Disease

Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, and David E.C. Cole

8. G Protein-coupled Receptor Pharmacogenetics

Miles D. Thompson, Katherine A. Siminoivitch, and David E.C. Cole

9. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders

Hamid Mostafavi Abdolmaleky and Sam Thiagalingam

10. Pharmacogenomics in Alzheimer’s Disease

Ramón Cacabelos

11. Pharmacogenetics of Asthma

Gregory A. Hawkins and Stephen P. Peters

12. From SNPs to Functional Studies in Cardiovascular Pharmacogenomics

Sharon Cresci

13. Pharmacogenomics in Gastrointestinal Disorders

Michael Camilleri and Yuri A. Saito

14. Pharmacogenomics in Rheumatoid Arthritis

Prabha Ranganathan

15. Cancer Pharmacogenetics

Sharon Marsh

16. Pharmacogenomics in the Preclinical Development of Vaccines: Evaluation of Efficacy and Systemic Toxicity in Mouse Using Array Technology

Karin J. Regnström

17.Pharmacogenomics in the Evaluation of Efficacy and Adverse Events during Clinical Development of Vaccines

Lennart J. Nilsson and Karin J. Regnström

Editorial Reviews

From the reviews:

"This volume in the Methods in Molecular Biology series covers pharmacogenomics in drug discovery. … The book is intended for scientists in academic, industrial, and health care settings who are striving to transform disease treatment into disease prevention. … The advanced technologies are presented in a very detail manner, even including step-by-step protocols. … By covering topics from individual molecules to systemic diseases … this book provides an overview of current knowledge on the use of pharmacogenomics in therapeutics of disease." (Xiaobo Zhong, Doody’s Review Service, July, 2008)

From the Publisher

Reviewer: Xiaobo Zhong, Ph.D.(University of Kansas Medical Center)
Description: This volume in the Methods in Molecular Biology series covers pharmacogenomics in drug discovery. The authors are from both academic and industrial settings worldwide, and are pioneer researchers in their fields.
Purpose: The purpose is to provide a practical and integrative view of the application of pharmacogenomics in drug discovery and development.
Audience: The book is intended for scientists in academic, industrial, and health care settings who are striving to transform disease treatment into disease prevention.
Features: The 17 chapters focus on three aspects of pharmacogenomics. First, the book introduces some important cutting-edge technologies that are useful for the development of systems-based pharmacogenomics to address complex issues. It then details approaches to studying gene-drug interactions, that is, how drugs act and how they are processed in the human body. Finally, the book discusses how pharmacogenomics can be used in therapeutics of a variety of diseases, including cardiovascular diseases, cancer, neurological diseases, gastrointestinal disorders, autoimmune diseases, and infectious diseases.
Assessment: This book provides both fundamental concepts and advanced technologies for the application of pharmacogenomics in the prediction and treatment of human diseases. The advanced technologies are presented in a very detail manner, even including step-by-step protocols. One chapter describes how to use bioinformatic tools to systematically understand pharmacogenomic data at different levels. Comprehensive information for many diseases is discussed, including biomarkers involved in the diseases and the associations among genes, drugs, diseases, drug response phenotypes, and the environment. By covering topics from individual molecules to systemic diseases, from fundamental concepts to advanced technologies, this book provides an overview of current knowledge on the use of pharmacogenomics in therapeutics of disease.

Doody's Review Service

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