Pub. Date:
Springer-Verlag New York, LLC
Pharmacogenomics in Drug Discovery and Development / Edition 1

Pharmacogenomics in Drug Discovery and Development / Edition 1

by Qing Yan
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This comprehensive volume explores cutting-edge technologies used to pursue systems-based pharmacogenomics. Extensive chapters follow on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.

Product Details

ISBN-13: 9781617378256
Publisher: Springer-Verlag New York, LLC
Publication date: 11/19/2010
Series: Methods in Molecular Biology , #448
Edition description: Softcover reprint of hardcover 1st ed. 2008
Pages: 487
Product dimensions: 6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Table of Contents

1. The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery

Qing Yan

2. Applications of Microarrays and Biochips in Pharmacogenomics

Gary Hardiman

3. Confounding in Genetic Association Studies and Its Solutions

Donglei Hu and Elad Ziv

4. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches

Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg

5. Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy

Tessa M. Bosch

6. Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease

Miles D. Thompson, David E.C. Cole and Pedro A. Jose

7. G Protein-coupled Receptors Disrupted in Human Genetic Disease

Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, and David E.C. Cole

8. G Protein-coupled Receptor Pharmacogenetics

Miles D. Thompson, Katherine A. Siminoivitch, and David E.C. Cole

9. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders

Hamid Mostafavi Abdolmaleky and Sam Thiagalingam

10. Pharmacogenomics in Alzheimer’s Disease

Ramón Cacabelos

11. Pharmacogenetics of Asthma

Gregory A. Hawkins and Stephen P. Peters

12. From SNPs to Functional Studies in Cardiovascular Pharmacogenomics

Sharon Cresci

13. Pharmacogenomics in Gastrointestinal Disorders

Michael Camilleri and Yuri A. Saito

14. Pharmacogenomics in Rheumatoid Arthritis

Prabha Ranganathan

15. Cancer Pharmacogenetics

Sharon Marsh

16. Pharmacogenomics in the Preclinical Development of Vaccines: Evaluation of Efficacy and Systemic Toxicity in Mouse Using Array Technology

Karin J. Regnström

17.Pharmacogenomics in the Evaluation of Efficacy and Adverse Events during Clinical Development of Vaccines

Lennart J. Nilsson and Karin J. Regnström

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