Photoreceptors and Calcium / Edition 1

by Wolfgang Baehr, Krzysztof Palczewski

Overview

This volume foxuses on the status of Ca²⁺ ions in regulation of phototransduction, light adaptation and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca²⁺-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events invovling Ca²⁺ in the retinal pigment epithelium, in synaptic transmission and secondary retinal neurons. A significant part of the book is dedicated to the role of Ca²⁺ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore association of gene defects with human retina disease and the generation of animal models of retinal degeneration.

Product Details

ISBN-13:	9780306474156
Publisher:	Springer US
Publication date:	01/31/2003
Series:	Advances in Experimental Medicine and Biology , #514
Edition description:	2002
Pages:	625
Product dimensions:	7.01(w) x 10.00(h) x 0.07(d)

Table of Contents

1. Calcium and Phototransduction.- 2. The Calcium Gradient Along the Rod Outer Segment.- 3. The Time Course of Light Adaptation in Vertebrate Retinal Rods.- 4. S-Modulin.- 5. Ca2+-Dependent Control of Rhodopsin Phosphorylation: Recoverin and Rhodopsin Kinase.- 6. Recoverin and Rhodopsin Kinase.- 7. Pathological Roles of Recoverin in Cancer-Associated Retinopathy.- 8. Rgs9-1 Phosphorylation and Ca2+.- 9. Phosphorylation by Cyclin-Dependent Protein Kinase 5 of the Regulatory Subunit (p?) of Retinal Cgmp phosphodiesterase (pde6): its Implications in Phototransduction.- 10. Centrins, Anovel Group of Ca2+-Binding Proteins in Vertebrate Photoreceptor Cells.- 11.Tuning Outer Segment Ca2+Homeostasis to Phototransduction in Rods and Cones.- 12. Regulation of the Rod Photoreceptor Cyclic Nucleotide-Gated Channel.- 13. Ca2+-Channels in the Rpe.- 14. THE RETINAL ROD AND CONE Na+/Ca2+-K+EXCHANGERS.- 15.THE COMPLEX OF cGMP-GATED CHANNELAND Na+/Ca2+-K+EXCHANGER IN ROD PHOTORECEPTORS.- 16. Regulation of Voltage-8Ensitive Ca2+Channels in Bipolar Cells by Divalent Cations and Polyamines.- 17. Site-Directed and Natural Mutations in Studying Functional Domains in Guanylyl Cyclase Activating Proteins (Gcaps).- 18. Calmodulin and Ca2+-Binding Proteins (Cabps): Variations on Atheme.- 19. GCAPs: Ca2+-SENSITIVE REGULATORS OF retGC.- 20. Structure and Membrane-Targeting Mechanism of Retinal Ca2+-Binding Proteins, Recoverin and Gcap-2.- 21. Target Recognition of Guanylate Cyclase by Guanylate Cyclase-Activating Proteins.- 22. Mouse Models to Study Gcap Functions in Intact Photoreceptors.- 23. Calcium-Dependent Activation of Guanylate Cyclase by S100b.- 24. The Role of Cadherins in Ca2+-Mediated Cell Adhesion and Inherited Photoreceptor Degeneration.- 25. Guanylate Cyclase Activating Proteins,Guanylate Cyclase and Disease.- 26. Using Mutant Mice to Study the Role of Voltage-Gated Calcium Channels in the Retina.- 27. Caldendrins in the Inner Retina.- 28. Calcium Channels at the Photoreceptor Synapse.- 29. On Bipolar Cells: Following in the Footsteps of Phototransduction.- 30. Ca2+Regulation of Drosophila Phototransduction.- 31. Simultaneous Roles for Ca2+in Excitation and Adaptation of Limulus Ventral Photoreceptors.- 32. Calcium Homeostasis in Fly Photoreceptor Cells.- 33. Photoreceptor Degeneration and Ca2+Influx Through Light-Activated Channels of Drosophila.- 34. The Trp Calcium Channeland Retinal Degeneration.