Portal Hypertension: Pathobiology, Evaluation, and Treatment / Edition 1

by Arun J. Sanyal, Vijay H. Shah

Overview

A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.

Product Details

ISBN-13:	9781588293862
Publisher:	Springer-Verlag New York, LLC
Publication date:	05/11/2005
Series:	Clinical Gastroenterology
Edition description:	2005
Pages:	528
Sales rank:	639,618
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

Historical Perspective.- Portal Hypertension.- Pathobiology and Experimental Progress in Portal Hypertension.- Anatomy and Vascular Biology of the Cells in the Portal Circulation.- Cell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic Correlates.- Molecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of Cirrhosis.- Mechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunction in Cirrhosis.- Hepatic Hemodynamics in Portal Hypertension.- Neovascularization, Angiogenesis, and Vascular Remodeling in Portal Hypertension.- Mechanisms of Cardiopulmonary Hemodynamics and Dysfunction in Portal Hypertension.- Methodology to Assess Portal Hypertension in Humans.- Measurement of Hepatic Venous Pressure Gradient.- Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques.- Endoscopic Assessment of Portal Hypertension Including Variceal Pressure Measurements.- Natural History and Treatment of Esophageal Varices.- Clinical Features and Natural History of Variceal Hemorrhage.- Management Strategies for the Prophylaxis and Treatment of Esophageal Variceal Rupture.- Pharmacologic Therapy for Management of Esophageal Varices.- Endoscopic Treatment for Bleeding Esophageal Varices.- Surgical Therapies for Management.- Transjugular Intrahepatic Portosystemic Stent-Shunt.- Clinical Features and Management of Gastric Varices, Portal Hypertensive Gastropathy, and Ectopic Varices.- Natural History and Treatment of Ascites and Hepatorenal Syndrome.- Ascites.- Management of Ascites.- Spontaneous Bacterial Peritonitis and Other Infections in Cirrhosis.- Diagnosis and Management of the Hepatorenal Syndrome.- Evaluation and Treatment in Special Circumstances of Portal Hypertension.- Pregnancy and Portal Hypertension.- Causes and Management of Portal Hypertension in the Pediatric Population.- Noncirrhotic Portal Hypertension and Portal Vein Thrombosis.- Hepatic Venous Outflow Obstruction.- Pulmonary Complications Associated with Portal Hypertension.- Health Status Assessment and Economic Analyses in Cirrhosis and Portal Hypertension.- Future Treatments.

Editorial Reviews

Reviewer: Iliana S Bouneva, M.D.(University of Kentucky College of Medicine)
Description: This is a comprehensive, wonderfully organized, state-of-the art review of multiple aspects of the rapidly developing field of portal hypertension, including its pathobiology, methods of evaluation, and clinical management.
Purpose: The purpose is to provide an update from leading experts in the field on investigative aspects of portal hypertension and to give practical tools to clinicians for assessment and management of a wide variety of clinical circumstances related to portal hypertension.
Audience: This book is intended for investigators actively involved in basic and clinical research in the area of portal hypertension and also for clinicians taking care of patients with various clinical manifestations of portal hypertension. In addition, the book would be a very useful companion for physicians-in-training to help facilitate better understanding of the pathogenesis of portal hypertension and to provide a basis for a better, evidence-based clinical care of patients with portal hypertension.
Features: There has been a remarkable progress within the field of portal hypertension over the past several years, which has necessitated a book such as Dr. Sanyal's, written in such depth. The book provides a detailed description of pathology and pathogenesis of portal hypertension, including its cellular and molecular mechanisms and electrolyte and hemodynamics derangements. Both invasive and noninvasive methodologies to assess portal hypertension are discussed. The book provides an outstanding clinical review on the natural history and treatment of esophageal varices, ascites, and hepatorenal syndrome. Special clinical circumstances, such as portal hypertension in pregnancy and in the pediatric population, portal hypertension due to portal vein thrombosis and hepatic venous outflow obstruction, pulmonary complications associated with portal hypertension, and future treatment modalities, are also extensively discussed.
Assessment: This book provides exceptional reading material encompassing a broad range of topics on both basic and clinical aspects of portal hypertension. I strongly recommend Dr. Sanyal's book to researchers, practicing physicians, trainees, and others with an interest in this subject.

Doody's Review Service

"...truly insightful...the book beautifully builds upon the molecular and biological machinery into an enhanced clinical understanding of portal hypertension complete with the most up-to-date treatment options." - Practical Gastroenterology

"...provides exceptional reading material encompassing a broad range of topics on basic and clinical aspecgts of portal hypertension...strongly recommended to researchers, practicing physicians, trainees, and others with an interest in this subject." Weighted Numerical Score: 96 - 4 Stars! - Doody's Health Science Book Review Journal

"...the ideal guide for those who want to deal with the clinical problems of portal hypertension in a modern and effective way." - Digestive and Liver Disease

From the Publisher

4 Stars! from Doody