Pre-Clinical and Clinical Methods in Brain Trauma Research

by Amit K. Srivastava, Charles S. Cox

Overview

This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.


Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.

Product Details

ISBN-13:	9781493985630
Publisher:	Springer New York
Publication date:	06/29/2018
Series:	Neuromethods , #139
Edition description:	1st ed. 2018
Pages:	381
Product dimensions:	7.01(w) x 10.00(h) x (d)

Table of Contents

Series Preface…
Preface…
Table of Contents…
Contributing Authors…

1. Traumatic Brain Injury
Amit K. Srivastava and Charles S. Cox, Jr.


2. Three-Dimensional In Vitro Brain Tissue Models
Min D. Tang-Schomer


3. Modeling Traumatic Brain Injury In Vitro
Daniel E. Bonder, Carolyn E. Keating, Namas Chandra, D. Kacy Cullen, and Bryan J. Pfister

4. Drosophila Model to Study Chronic Traumatic Encephalopathy
Rojahne Azwoir and Liam Chen


5. Controlled Cortical Impact for Modeling Traumatic Brain Injury in Animals
Nicole Osier and C. Edward Dixon


6. Fluid Percussion Model of Traumatic Brain Injury
Rachel K. Rowe, Daniel Griffiths, and Jonathan Lifshitz


7. Development of a Rodent Model of Closed Head Injury: The Maryland Model
Erik Hayman, Kaspar Kaledjian, Vladimir Gerzanich, and J. Marc Simard


8. Rodent Model of Primary Blast-Induced Traumatic Brain Injury: Guidelines to Blast Methodology
Venkatasivasai Sujith Sajja, Arun Peethambaram, Stephen A. Van Albert, and Joseph B. Long


9. Cognitive and Motor Function Assessments in Rodent Models of Traumatic Brain Injury
Danielle Scott and Kathryn E. Saatman

10. Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain Injury
Mary A. Robinson, Samer M. Jaber, Stacey L. Piotrowski, and Thomas H. Gomez


11. Laser Capture Microdissection of Single Cells, Cell Populations, and Brain Regions Affected by Traumatic Brain Injury
Harris A. Weisz, Deborah R. Boone, Stacy L. Sell, and Helen L. Hellmich

12. Rat Microglia Isolation and Characterization Using Multi-Parametric Panel for Flow Cytometric Analysis
Naama E. Toledano Furman, Karthik S. Prabhakara, Supinder Bedi, Charles S. Cox Jr., and Scott D. Olson


13. The Principles of Experimental Design and the Determination of Sample Size When Using Animal Models of Traumatic Brain Injury Michael F.W. Festing


14. Advanced Informatics Methods in Acute Brain Injury Research
Jude P.J. Savarraj, Mary F. McGuire, Ryan Kitagawa, and Huimahn Alex Choi


15. Rapid Detection and Monitoring of Brain Injury Using Sensory Evoked ResponsesJonathan A. N. Fisher and Cristin G. Welle


16. Advanced Neuroimaging Methods in Traumatic Brain Injury
Jenifer Juranek


17. Dynamic Contrast Enhanced MRI for the Analysis of Blood-Brain Barrier Leakage in Traumatic Brain Injury Qiang Shen and Timothy Q. Duong


18. Assessments for Quantifying Neuromotor Functioning after Repetitive Blast Exposure
Christopher K. Rhea, Nikita A. Kuznetsov, W. Geoff Wright, F. Jay Haran, Scott E. Ross, and Josh L. Duckworth


19. Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury
Yuri Danilov and Dafna Paltin


20. The Rapid Templating Process for Large Cranial Defects
Jeremy Kwarcinski, Philip Boughton, Andrew Ruys, and James van Gelder


21. Computer-Assisted Approaches to Identify Functional Gene Networks Involved in Traumatic Brain Injury
Anthony San Lucas, John Redell, Pramod Dash, and Yin Liu


22. Clinical Trials for Traumatic Brain Injury: Designs and Challenges
Juan Lu and Mirinda Gormley