Pre-Invasive Disease: Pathogenesis and Clinical Management / Edition 1

by Rebecca C. Fitzgerald

Overview

This book is written by International experts in their field and should appeal to students and seasoned researchers, to scientists and to clinicians. No prior knowledge of the topic is required to appreciate this text and yet the book charters new territory. New perspectives are given on how our knowledge of cancer development might lead us to reconsider our clinical approach to early detection and prevention of cancer at an individual and population level.

Product Details

ISBN-13:	9781441966933
Publisher:	Springer New York
Publication date:	10/15/2010
Edition description:	2011
Pages:	519
Product dimensions:	6.30(w) x 9.20(h) x 1.30(d)

About the Author

Rebecca Fitzgerald is a tenured Programme Leader at the Medical Research Council (MRC) Cancer Cell Unit in Cambridge and her research is in Barrett's oesophagus with a particular focus on early cancer detection. She trained at Cambridge University, conducted her doctoral research at Stanford University, California and came to the UK for her post-doctoral research and specialist clinical training at St. Barts and the London Hospitals before returning to Cambridge. Rebecca maintains an clinical active practice as an honorary consultant in Gastroenterology at the University teaching hospital Addenbrooke's and enjoys teaching in her capacity as Director of Studies at Trinity College, Cambridge.

Table of Contents

Part I Pathogenesis

1 Stem Cells in Intraepithelial Neoplasia Nicholas A. Wright 3

2 The Inflammatory Tissue Microenvironment and the Early Stages of Malignancy Fran Balkwill 21

3 Hereditary Factors and Pre-invasive Disease Paul D. P. Pharoah 31

4 Epigenetic Alterations as Contributors to the Pathogenesis, Detection, Prognosis and Treatment of Human Pre-Neoplasia Stefan David Stephen J. Meltzer 41

5 The Progression of Pre-Invasive to Invasive Cancer Souzan Sanati D. Craig Allred 65

6 Contribution of the-Omics Era to our Understanding of Pre-Invasive Disease and Progression to Cancer Rita A. Busuttil Alex Boussioutas 77

7 Somatic Evolution in Neoplastic Progression and Cancer Prevention Carlo C. Maley Eva Szabo Brian J. Reid 111

Part II Model Systems and Clinical Approaches

8 Precancer in animal Models: Sequentially Acquired or Predetermined Robert D. Cardiff Alexander D. Borowski 131

9 Biomarkers for Detection of Intra-epithelial Neoplasia Kareem M. Shariff Pierre Lao-Sirieix 151

10 Molecular Imaging of Cancer and the Implications for Pre-Invasive Disease Scott K. Lyons Kevin M. Brindle 167

11 Chemoprevention Richard A. Hubner 209

12 Endoscopic Treatment of Early Lesions with Particular Reference to Barrett's Oesophagus Namasivayam Vikneswaran Kenneth K Wang 227

13 Psychosocial Outcomes of Screening for Cancer and Pre-invasive Disease Robert N. Whistance Shelley Potter Mark Eveleigh Jane M. Blazeby 245

Part III Disease Specific Examples

14 Pre-invasive Disease of the Lung Ornella Belvedere Anindo K. Banerjee Pamela Rabbits 271

15 Progress in Early Detection and Management of Oral Dysplasia: Components for a Multifaceted Progression Risk Model Miriam P. Rosin Catherina F. Poh S.Y. Catherina Kang Calum E. MacAulay Lewei Zhang 297

16 Barrett's Oesophagus Rebecca Fitzgerald 315

17 Helicobacter Infection: Infection, Immunity and the Progression of Lesions to Invasive Gastric Cancer Evelyn Kurt-Jones JeanMarie Houghton 341

18 Pathways and Crossroads to Colorectal Cancer Elisa Cattaneo Michael Baudis Federico Buffoli Maria Natonia Bianco Fausto Zorzi Giancarlo Marra 369

19 Precursor Lesions of Pancreatic Cancer Hanno Matthaei Anirban Maitra 395

20 Breast: Ductal Carcinoma In Situ (DCIS) John P. Brown Sarah E. Pinder 421

21 Molecular Pathogenesis, Detection and Clinical Management of Pre-invasive Cervical Lesions Wen-Chung Chen Barbara Ma Chih-Ping Mao T-C Wu 437

22 Pre-malignant Disease in the Prostate Alastair D. Lamb Anne Y. Warren David E. Neal 467

Part IV Common Threads

23 Early Disease, Early Detection, Early Treatment: Some Common Threads and Some Important Problems John Potter 495

Index 509