Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition

by Raffaele De Caterina PhD, J. Alfredo Martinez PhD, Martin Kohlmeier PhD

Overview

Approx.566 pages

Product Details

ISBN-13:	9780128045725
Publisher:	Elsevier Science
Publication date:	09/19/2019
Pages:	586
Product dimensions:	8.50(w) x 10.88(h) x (d)

About the Author

Raffaele De Caterina is a Professor of Cardiology at the University of Pisa and Director of the University Cardiology Division at Pisa University Hospital, Pisa, Italy. He has been President of the International Society on Nutrigenetics/Nutrigenomics (2009-2013) and vice-President of the European Society of Cardiology (2008-2010). He is Editor-in-Chief of the journal Vascular Pharmacology and author of over 600 peer-reviewed manuscripts. His major research interests include cardiovascular pharmacology, atrial fibrillation, coronary artery disease, and cardiovascular thrombosis, as well as nutrigenetics and nutrigenomics.

Prof. J. Alfredo Martínez has been involved in several landmark intervention trials and more than 50 national and international projects. He has supervised more than 70 PhD students and published more than 800 peer-reviewed manuscripts and book chapters in the areas of obesity and personalized nutrition, including precision nutritional omics. His works have been cited more than 26,000 times, and his HFactor is over 64. He has been President of the International Society of Nutrigenetics/Nutrigenomics (2015-2017) and is President of the International Union of Nutritional Sciences (IUNS) for the 2017-2021 period. Prof. Martínez has enjoyed training or invited stays at the University of Nottingham, Berkeley College, MIT, Harvard University, Oxford University, and King’s College London. He has been an advisor for EU Projects or a guest speaker or main keynote lecturer in important forums concerning precision nutrition in obesity and cardiometabolic diseases, including IUNS, ISNN, OMS, FAO, IAEA, NIH, SLAN, and FENS.

Dr. Martin Kohlmeier, MD, PhD, is a Professor of Nutrition; Director of the Human Research Core and the Nutrigenetics Laboratory at the UNC Nutrition Research Institute in Kannapolis, NC; Director of Nutrition in Medicine for online nutrition education of medical students and health professionals; visiting fellow of Wolfson College at Cambridge University, UK; founding Editor-in-Chief of BMJ Nutrition, Prevention and Health; and President of the International Society of Nutrigenetics/Nutrigenomics (ISNN). His professional interests include investigating genotype-specific nutrition responses of humans in health and disease, developing decision-support algorithms and tools for precision nutrition, and teaching health care professionals how to use nutrigenetics in practice. His previously authored textbooks in the field include Nutrigenetics (Academic Press, 2013) and Nutrient Metabolism (2nd Edition, Academic Press, 2015).

Table of Contents

Section 1: The biological basis of heritability and diversity
1. The nature of traits, genes and variation
2. Molecular biology of genetic variants
3. Regulation of Gene Expression
4. The role of nutrition in DNA replication, DNA damage prevention and DNA repair
5. Genotyping and sequencing
6. RNA analyses
7. Methods in Nutrigenomics for precision nutrition
8. Epigenetics: Methodology and tools for nutrition research
9. Proteomic analyses
10. Metabolomic analyses
11. Metagenomics
12. A Broader View on Omics and Systems Biology
13. Study design in genomic epidemiology
14. Epistemology of nutrigenetic knowledge

Section 2: Nutrigenetics
15. Nutrigenetics and the early life origins of health and disease: effects of protein restriction
16. Perinatal nutrition
17. Epigenetics Mechanisms
18. Genetics of Chrononutrition
19. Newborn screening
20. Genomics of Eating Behavior and Appetite Regulation
21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness
22. Genetic regulation of energy homeostasis: obesity implications
23. Genetic variations in the response to weight-loss diets
24. Genetic variations in the response to exercise: impact on physical fitness and performance
25. Genetic variations impacting the response to defined diets
26. Carbohydrates
27. Monounsaturated and Saturated Fatty Acids
28. Omega-3 and omega-6 fatty acids
29. Blood cholesterol
30. Genetic Individuality and Alcoholic Consumption
31. Vitamin A and other carotenoids
32. Vitamin D
33. Vitamin E
34. Vitamin K
35. Vitamins as Cofactors for Energy Homeostasis: Biotin, Thiamine and Pantothenic Acid
36. Vitamin C
37. Vitamin B2
38. Niacin
39. Folate, vitamin B6, vitamin B12
40. Choline
41. Electrolytes
42. Iron
43. Trace elements
44. Polyphenols and Nutrigenetic/Nutrigenomic Associations with Obesity-Related Metabolic Diseases
45. Caffeine
46. Phytanic acid
47. Cognitive function
48. Cardiovascular Disease
49. Hemostasis and thrombosis
50. Diabetes mellitus
51. Bone health
52. Nutrients and Genes in the Liver
53. Hyperuricemia and gout
54. Aging
55. Epigenetics in food allergies: the missing piece of the puzzle
56. Gut microbiota and their influence on the response to foods

Section 3: Nutrigenomics
57. Nutrients and Gene Expression in Development
58. Nutrients and gene expression in Obesity
59. Nutrients and gene expression in Diabetes
60. Gene expression in dyslipidemias
61. Nutrients and gene expression in Inflammation
62. Nutrients and gene expression in Cardiovascular Disease
63. Nutrients and Gene Expression in Cancer
64. Nutrients and Gene Expression Affecting Bone Metabolism

Section 4: Translational nutrigenetics and nutrigenomics
65. Nutrigenetics-based intervention studies
66. Genome-based nutrition guidance
67. Nutrigenomics of food pesticides
68. Pharmaconutrigenetics: the impact of genetics on nutrient-drug interactions
69. Setting genome-directed guidelines and algorithms
70. Direct-to-consumer services
71. Privacy risks and protective measures
72. Ethical considerations in nutrigenetics and nutrigenomics
73. Impact of Nutrigenetics and Nutrigenomics on Society

What People are Saying About This

From the Publisher

Authoritative and foundational, this book clearly presents evidence and practical guidance from the ground up