Disc 1
- Cross Road Blues - Robert Johnson
- That's All Right - Arthur "Big Boy" Crudup
- The Blues Had a Baby and They Named It Rock and Roll - Brownie McGhee - McKinley Morganfield - Muddy Waters
- Need Your Love So Bad - Fleetwood Mac - Little Willie John
- Lovin' in My Baby's Eyes - Taj Mahal
- I'm Your Hoochie Coochie Man - Willie Dixon
- Death Letter Blues - Son House
- Whiskey Headed Blues - John Lee Williamson - Sonny Boy Williamson
- Crying in My Sleep - Jimmy Yancey
- Muddy Water (A Mississippi Moan) - Harry Richman - Bessie Smith
- Motherless Children - Blind Willie Johnson
- Fort Worth and Dallas Blues - Lead Belly - Alan Lomax
- I'm Gonna Train My Baby - Robert Jr. Lockwood
- Seminole Blues - Tampa Red - Hudson Whittaker
- Johnny B. Goode - Chuck Berry - Johnny Winter
- Got My Mojo Workin' - Preston Foster - Otis Spann
- River of No Return - Jeff Healey - Keith Reid - Jon Tiven - Sally Tiven
Disc 2
- Blues for Mama - Abbey Lincoln - Nina Simone
- Pride and Joy - Stevie Ray Vaughan - Vaughan
- Killing Floor - C. Burnett - Electric Flag
- I'd Rather Go Blind - Chicken Shack - Ellington Jordan
- Early in the Morning - Jazz Gillum
- Give Me an Old, Old Lady - Bukka White
- Baby, Please Don't Go - Big Joe Williams - Joseph Lee Williams
- Stormy Monday Blues - Bob Crowder - Billy Eckstine - Earl Hines - Hines
- That Ain't Right - Mildred Bailey - Nat King Cole - Irving Mills
- Sunny Road - Roosevelt Sykes - Sykes
- Bumble Bee Blues - Minnie McCoy - Memphis Minnie
- Worried Life Blues - Big Maceo Merriweather
- Confessin' the Blues - Walter Brown - Jay McShann & His Band - Jay McShann - Jimmy Witherspoon
- No More Women Blues - T. Alexander - Lonnie Johnson
- When the Sun Goes Down - Leroy Carr
- Honky Tonk Train Blues - Meade "Lux" Lewis
- Beer Drinkin' Woman - Peter Chatman - Memphis Slim
Disc 3
- Hard to Be - Nile Rodgers - Vaughan Brothers - Stevie Ray Vaughan
- Sawbuk - Anthony "Top" Topham - Top Topham
- Cleanhead Blues - Eddie "Cleanhead" Vinson
- Hold Me (Just a Little Longer Tonight) - Etta James - Graham Lyle - Troy Seals
- Baby Don't You Think I Know - Johnny Shines
- Everyday I Have the Blues - Peter Chatman - Joe Williams
- Broke and Hungry Blues - Big Maceo Merriweather
- Prowling Night Hawk - Robert Lee McCoy
- Deep Down in the Ground - John Lee Williamson - Sonny Boy Williamson
- Rag Mama Rag - Blind Boy Fuller - J.B. Long
- I Love My Baby - Tommy McClennan
- Mean Old Frisco Blues - Arthur "Big Boy" Crudup
- Sweet Home Chicago - Robert Johnson
- Careless Love - Gene Page - Traditional - Big Joe Turner
- Friendless Blues - Big Bill Broonzy
- She's Makin' a Fool Out of Me - Louie Lasky - Washboard Sam & His Washboard Band
- Billie's Blues (I Love My Man) - Billie Holiday - Holiday
Disc 4
- Howling Wolf - McKinley Morganfield - Muddy Waters
- I've Got to Forget You - Jellybread - Deadric Malone
- Corinna - Jesse Ed Davis - Taj Mahal
- Let Me Miss You, Baby - Henry "Red" Allen
- Back o' Town Blues - Louis Armstrong - Armstrong
- Rocks in My Bed - Duke Ellington - Ellington
- Brand New Wagon - Count Basie - Basie - Jimmy Rushing
- St. Louis Blues - W.C. Handy - Teagarden
- The Blues in My Flat - Goodman - Lionel Hampton
- Why Don't You Do Right? (Get Me Some Money Too) - Lil Green - Kansas Joe McCoy
- Kassie Jones, Pt. 1 - Furry Lewis
- Wipe It Off - Lonnie Johnson
- Southern Can Is Mine - Blind Willie McTell
- Key to the Highway 70 No. 1 - Brownie McGhee
- Lend Me Your Love - Peter Chatman - Memphis Slim
- Am I Wrong - Keb Mo - Kevin R. Moore
- JB's Blues - Geoffrey Beck - Jeff Beck - Dean Garcia