Radiobiology Self-Assessment Guide / Edition 1

by Jennifer Yu MD, PhD, Mohamed Abazeed MD, PhD

Overview

Radiobiology Self-Assessment Guide—a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide—is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along with reference citations for source information.

The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute and Lerner Research Institute.

Key Features:

• Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam
• Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review
• Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents
• Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents

Product Details

ISBN-13:	9781620701140
Publisher:	Springer Publishing Company
Publication date:	11/23/2016
Pages:	520
Product dimensions:	7.00(w) x 9.90(h) x 1.10(d)

About the Author

Jennifer Yu, MD, PhD, Associate Staff Physician, Departments of Radiation Oncology and Stem Cell Biology and Regenerative Medicine, Taussig Cancer Institute and Lerner Research Institute, Cleveland Clinic, Cleveland OH

Mohamed Abazeed, MD, PhD, Associate Staff Physician, Departments of Radiation Oncology and Translational Hematologic and Oncologic Research, Taussig Cancer Institute and Lerner Research Institute, Cleveland Clinic, Cleveland OH

Table of Contents

CONTENTS

Contributors

Preface

1. Interaction of Radiation With Matter

John F. Greskovich, Jr., Mihir Naik, and Marc Apple

2. Cell Survival Curves and Cell Death

Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan

3. DNA, Chromosome and Chromatid Damage, Repair, and Measurement

Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan

4. Radiosensitivity and the Dose-Rate Effect

Brian D. Yard and Mohamed E. Abazeed

5. Radiation Damage Repair and Models for Normal Tissues

Aditya Juloori, Choamei Xiang, Michael A. Weller, and Jennifer S. Yu

6. Hypoxia, Oxygen, Reoxygenation, and Angiogenesis

Xingjiang Yu, Jennifer S. Yu, and Eli Bar

7. Linear Energy Transfer and Relative Biological Effectiveness

Yvonne Pham and Chirag Shah

8. Assays for Cell, Tissue, and Solid Tumors

C. Marc Leyrer, Ehsan H. Balagamwala, and Camille Berriochoa

9. Molecular Techniques, Assay Systems, and Signaling in Radiobiology

Kailin Yang and Jennifer S. Yu

10. Biology of Cancer

Kailin Yang and Jennifer S. Yu

11. Model Tumor Systems and Predictive Assays

C. Marc Leyrer, Camille Berriochoa, and Ehsan H. Balagamwala

12. Cell Kinetics

Matthew C. Ward and Richard Blake Ross

13. Factors Influencing Tumor Control and Complications

Daesung Lee

14. Impact of Time, Dose, and Fractionation in Radiation Oncology

Daesung Lee

15. Effects of Total Body Irradiation

Sudha Amarnath

16. Radiation Sensitizers, Radioprotectors, and Bioreductive Drugs

Aditya Juloori and Michael A. Weller

17. Radiation Carcinogenesis

Bindu V. Manyam and Michael A. Weller

18. Effects of Radiation on Hereditary Damage, Mutations, and Chromosome Aberrations

Camille Berriochoa, C. Marc Leyrer, and Anthony Mastroianni

19. Effects of Radiation on the Embryo and Fetus

Yvonne Pham and Steven Oh

20. Doses and Risks in Nonradiation Oncology Subspecialties

Frank Dong, Kevin Wunderle, and Salim Balik

21. Radiation Protection

Taoran Cui and Peng Qi

22. Alternative Radiation Therapy Modalities

Susan Kost and Andrew Godley

23. Brachytherapy and Stereotactic Radiosurgery

Sudha Amarnath

24. Gene Therapy

HyeonJoo Cheon

25. Chemotherapy and Targeted Agents

Nikhil Joshi and Neil Woody

26. Hyperthermia

Sharvari Dharmaiah, Vinay Rao, and Jennifer S. Yu

27. Stem Cells

Haidong Huang and Jennifer S. Yu

28. Immunotherapy

Nikhil Joshi and Neil Woody

29. Radiogenomics

Mohamed E. Abazeed

Index