RNA Interference: Challenges and Therapeutic Opportunities

by Sam Kennedy (Editor)

Overview

RNA interference (RNAi) is a genetic regulatory mechanism that occurs in eukaryotic cells and regulates the activity of genes. Its main function is to suppress, silence or deactivate genes. RNAi can occur either naturally or artificially. It occurs naturally through the production of pre-miRNA. RNAi can also be induced experimentally by using double-stranded RNA (dsRNA). The synthetic dsRNA may be of two types: small hairpin RNA (shRNA) or short interfering RNA (siRNA). An enzyme known as DICER is necessary in both natural and artificial pathways for the formation of miRNA from pre-miRNA or for the formation of siRNA from shRNA. This book traces the progress of this field and highlights some of its key concepts and applications. It studies, analyses and upholds the pillars of RNA interference and its utmost significance in modern times. This book includes contributions of experts and scientists which will provide innovative insights into this field.

Product Details

ISBN-13:	9781639874958
Publisher:	Murphy & Moore Publishing
Publication date:	03/01/2022
Pages:	246
Product dimensions:	7.00(w) x 10.00(h) x 0.63(d)

About the Author

Sam Kennedy pursued his MSc in Medical Genetics and Genomics from Oxford Brookes University, UK. He has conducted works on the role of epigenetics in shaping macrophage identity, RNA interference, and structure of chromatin. Kennedy has authored and edited numerous articles, journal papers and book chapters, which have been published worldwide. He has excelled in his professional life, and is currently working for the professor of the medical community.

Table of Contents

Preface vii

Chapter 1 RNAi-Induced Immunity Wenyi Gu 1

Chapter 2 Preclinical Development of RNAi-Inducing Oligonucleotide Therapeutics for Eye Diseases Tamara Martínez Maria Victoria González Beatriz Vargas Ana Isabel Jiménez Covadonga Pañeda 10

Chapter 3 Perspectives on RNA Interference in Immunopharmacology and Immunotherapy Zhaohua Hou Qiuju Han Cai Zhang Jian Zhang 38

Chapter 4 Utility of Potent Anti-Viral MicroRNAs in Emerging Infectious Diseases Zhabiz Golkar Donald G. Pace Omar Bagasra 63

Chapter 5 RNA Interference as a Tool to Reduce the Risk of Rejection in Cell-Based Therapies Cortstanca Figueiredo Rainer Blasczyk 77

Chapter 6 RNAi - Implications in Entomological Research and Pest Control Nidhi Thakur Jaspreet Kaur Mundey Santosh Kumar Upadhyay 91

Chapter 7 Management of Insect Pest by RNAi - A New Tool for Crop Protection Thais Barros Rodrigues Antonio Figueira 121

Chapter 8 RNA Interference - Natural Gene-Based Technology for Highly Specific Pest Control (HiSPeC) Eduardo C. de Andrade Wayne B. Hunter 141

Chapter 9 In Search of New Methodologies for Efficient Insect Pest Control: The RNAi "Movement" Anna Kourti Luc Swevers Dimitrios Kontogiannatos 160

Chapter 10 RNA Interference - A Powerful Functional Analysis Tool for Studying Tick Biology and its Control Remil Linggatong Galay Rika Umemiya-Shirafuji Masami Mochizuki Kozo Fujisaki Tetsuya Tanaka 185

Chapter 11 Current Status for Application of RNA Interference Technology as Nucleic Acid Drug Tomoko Takahashi Yuko Nakano Kumiko Ui-Tei 220

Permissions

List of Contributors

Index