Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture

by Tiago Albertini Balbino PhD (Editor), Paulo Bartolo PhD (Editor), Letícia Charelli MSc (Editor)

Overview

Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology.

The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry.

Product Details

ISBN-13:	9780443134036
Publisher:	Elsevier Science
Publication date:	06/18/2025
Pages:	230
Product dimensions:	7.50(w) x 9.25(h) x (d)

About the Author

Tiago Albertini Balbino, PhD, is a professor at the Alberto Luiz Coimbra Institute for Graduate Studies and Research in Engineering (COPPE) at the Federal University of Rio de Janeiro (UFRJ), Brazil. He coordinates the Graduate Program in Nanotechnology Engineering, which is housed at Latin America’s largest center for research and education in engineering. Professor Balbino is a chemical engineer with a PhD and master’s in chemical engineering from the UNICAMP (São Paulo, Brazil). His doctoral research focused on developing microfluidic processes for creating nanostructured systems used in vaccines and other nanomedicines, a focus he expanded during his internship at the National Institute of Standards and Technology (NIST) in the United States, where he worked on microfabrication techniques for biomedical applications. He later pursued a postdoctoral fellowship at the Department of Mechanical Engineering at PUC-Rio, advancing his expertise in microfluidic chip design. Currently, his work centers on designing innovative microfluidic chips to address challenges in nanotechnology engineering. He is also actively involved in advancing organ-on-chip technologies, with applications in drug development, disease modeling, and tissue engineering. His work bridges engineering and biomedical science, contributing to cutting-edge research that aims to transform healthcare and train the next generation of scientists and engineers.T

Paulo Bartolo is Professor of Advanced Manufacturing at the School of Mechanical and Aerospace Engineering (MAE), Nanyang Technological University (NTU), Executive Director of the Singapore Centre for 3D Printing (SC3DP), and Programme Director of the National Additive Manufacturing Innovation Cluster (NAMIC) hub at NTU. He is Fellow of CIRP (International Academy for Production Engineering), Honorary/Visiting Professor at several Universities in China, Europe and North America and Advisor of several Funding Agencies and Research Institutes across the world.

He authored/co-authored more than 700 publications in journal papers, book chapters and conference proceedings, co-edited 23 books and holds 16 patents in the fields of additive manufacturing, biomanufacturing and tissue engineering. Throughout his career he received several awards and public recognitions including the Gold Medal of Merit of the Portuguese Communities from the Portuguese Government, Professor Honoris Causa from the Polytechnic University of Leiria, the Kobayahi Award for his contributions in the field of biomanufacturing, commendations and public recognitions from the Portuguese Government and the Polytechnic University of Leiria published in the Portuguese Government’s Law Journal and the Medal of Merit from the city of Leiria among others. Paulo Bartolo is among the Top 2% Scientists Worldwide.

Ms. Letícia Charelli has a BSc and an MSc in Biotechnology with emphasis on biofabrication, 3D cell culture, and microfluidics. She is currently working with industry players to optimize protocols for regenerative medicine, drug development, and disease modeling. Letícia uses her extensive knowledge to translate the research data from the bench to the bedside as a functional product. Her expertise in microfluidics (e.g., organ-on-chip platforms) have resulted in several international articles, partnership with industries as well as lecturing for undergraduate, graduate, and professionals of several fields.

Table of Contents

SECTION 1: MICROFLUIDICS AND ORGAN-ON-CHIP TECHNOLOGIES
1. Organotypic On-Chip Models: Bridging the Gap Between Traditional In Vitro Culture and Animal Testing
2. Microfabrication Processes for the Manufacturing of Smart Organ-on-Chip Devices
3. Bioprinted Organ-on-a-Chip: A Strategy to Achieve Humanized In Vitro Models
4. Disease Modeling and Developmental Biology Through Microfluidic Channels
5. Artificial Intelligence-Assisted Organ-on-Chip Systems

SECTION 2: STIMULI ACTIVE ORGANOTYPIC-ON-CHIP DEVICES
6. Mechanically Active Organotypic-On-Chip Devices for Dynamic Cell Culture
7. Sensors within Microfluidic Chips: Optofluidics to Explore In Vitro Organoid Behavior
8. Photothermal and Magnetic Cell Stimuli Caused by Nanoparticles Inside Organ-on-Chip Platforms

SECTION 3: MICROPHYSIOLOGICAL CASE STUDIES
9. Brain-on-Chip Microplatforms for Precision Medicine, Disease Modelling, and Developmental Biology
10. Dynamic Microphysiological Systems to Access Sickle Cell Disease - A Case Study for Disease Modeling
11. Microtechnologies and Mathematical Modeling in Signaling Cascades Multiorgan Microphysiological Systems
12. Mechanically Active Heart-on-a-Chip: Toward a Reliable Heart Beating Study Model
13. Remaining Challenges: Are We Close to a Physiologically Representative In Vitro Model for Clinical Deployment?

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From the Publisher

A step-by-step guide for those using microfluidic devices as platforms