Statistical Methods in Genetic Epidemiology

by Duncan C. Thomas

Overview

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

Product Details

ISBN-13:	9780195159394
Publisher:	Oxford University Press
Publication date:	01/29/2004
Edition description:	New Edition
Pages:	464
Product dimensions:	6.46(w) x 9.40(h) x 1.03(d)

About the Author

University of Southern California Keck School of Medicine

Table of Contents

1. Overview of Genetic Epidemiology2. Basic Concepts of Molecular Genetics3. Principles of Mendelian Inheritance4. Basic Epidemiological and Statistical Principles5. Familial Aggregation6. Segregation Analysis7. Linkage Analysis8. Principles of Population Genetics9. Testing Candidate Gene Associations10. Linkage Disequilibrium Mapping11. Gene Characterization12. Tying it all together: The Genetic Epidemiology of Colorectal CancerGlossary

Editorial Reviews

"This book is well organized and logically developed, such that concepts are covered in broad strokes, revisited in greater detail, and connected together. ...this is a very thorough treatise of the spectrum of methods that collectively define genetic epidemiology." —Annals of Epidemiology

"...Statistical Methods in Genetic Epidemiology is a most welcome volume that all readers...should consider having on their bookshelves. It seems likely that this will serve as a classic text for many years to come." —American Journal of Human Genetics

"This is a clear succinct tour of the analytical side of genetic epidemiology. There is a suitable balance of biology and statistical details and the text is well pitched for its target audience of graduate epidemiologists, biostatisticians, and human geneticists."—International Journal of Epidemiology

From the Publisher