Stem Cell Engineering: Principles and Applications / Edition 1

by Gerhard M. Artmann, Stephen Minger, Jürgen Hescheler

Overview

The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Product Details

ISBN-13:	9783642118647
Publisher:	Springer Berlin Heidelberg
Publication date:	11/01/2010
Edition description:	2011
Pages:	547
Product dimensions:	6.20(w) x 9.20(h) x 1.50(d)

Table of Contents

Part I Instead of an Introduction - The Emperor's New Legs

The Emperor's New Body: Seeking for a Blueprint of Limb Regeneration in Humans Ilya Digel Aysegül Temiz Artmann 3

Part II Basics and Basic Research

Engineering the Stem Cell Niche and the Differentiative Micro- and Macroenvironment: Technologies and Tools for Applying Biochemical, Physical and Structural Stimuli and Their Effects on Stem Cells Paolo Di Nardo Marilena Minieri Arti Ahluwalia 41

Differentiation Potential of Adult Human Mesenchymal Stem Cells Edda Tobiasch 61

The Potential of Selectively Cultured Adult Stem Cells Re-implanted in Tissues Isgard S. Hueck Martin Haas Rita Finones Jane Frimodig David A. Gough 79

Enhanced Cardiac Differentiation of Mouse Embryonic Stem Cells by Electrical Stimulation Paul R. Bidez III J. Yasha Kresh Yen Wei Peter I. Lelkes 119

The Therapeutic Potential of ES-Derived Haematopoietic Cells Sabrina Gordon-Keylock Lesley Forrester 143

Genetic Modification of Human Embryonic and Induced Pluripotent Stem Cells: Viral and Non-viral Approaches Nicole M. Kane Chris Denning Andrew H. Baker 159

The Immune Barriers of Cell Therapy with Allogenic Stem Cells of Embryonic Origin Olivier Preynat-Seauve Karl-Heinz Krause Jean Villard 181

Reponses of Mesenchymal Stem Cells to Varying Oxygen Availability In Vitro and In Vivo Frank R. Kloss Sarvpreet Singh Günter Lepperdinger 199

Endothelial Progenitor Cells and Nitric Oxide: Matching Partners in Biomedicine Stefanie Keymel Burcin Özüyaman Marijke Grau Malte Kelm Petra Kleinbongard 213

Skeletal Stem Cells and Controlled Nanotopography Matthew J. Dalby Richard O.C. Oreffo 247

Part III Clinical Applications

Cells and Vascular Tissue Engineering John Paul Kirton Tsung-Neng Tsai Qingbo Xu 261

Endothelial Progenitor Cells for Vascular Repair Melissa A. Brown Cindy S. Cheng George A. Truskey 297

Regenerating Tubules for Kidney Repair W.W. Minuth L. Denk A. Roessger 321

Stem Cells in Tissue Engineering and Cell Therapies of Urological Defects Christoph Becker Katrin Montzka Gerhard Jakse 345

Bio-synthetic Encapsulation Systems for Organ Engineering: Focus on Diabetes Rylie A. Green Penny J. Martens Robert Nordon Laura A. Poole-Warren 363

Stem Cell Engineering for Regeneration of Bone Tissue Michael Gelinsky Anja Lode Anne Bernhardt Angela Rösen-Wolff 383

Part IV Techniques and Applications

Building, Preserving, and Applying Extracellular Culture Integrity Using New Cell Culture Methods and Surfaces Thomas Brevig Robin Wesselschmidt Masayuki Yamato 403

Fabrication of Modified Extracellular Matrix for the Bone Marrow-Derived Mesenchymal Stem Cell Therapeutics Hwal (Matthew) Suh 417

Neural Stem Cells: From Cell Fate and Metabolic Monitoring Toward Clinical Applications Jan Pruszak Máté Döbrössy Jochen Kieninger Kuppusamy Aravindalochanan Gerald A. Urban Guido Nikkhah 435

Adult Stem Cells in Drug Discovery Stefan Golz Andreas Geerts Andreas Wilmen 457

Embryonic Stem Cells as a Tool for Drug Screening and Toxicity Testing Bernd Denecke Silke Schwengberg 473

Embryonic Stem Cells: A Biological Tool to Translate the Mechanisms of Heart Development Omonigho A. Aisagbonhi Antonis K. Hatzopoulos 501

Index 521