Pub. Date:
Springer Berlin Heidelberg
Synaptic Plasticity and the Mechanism of Alzheimer's Disease / Edition 1

Synaptic Plasticity and the Mechanism of Alzheimer's Disease / Edition 1

by Dennis J. Selkoe, Antoine Triller
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Product Details

ISBN-13: 9783642095191
Publisher: Springer Berlin Heidelberg
Publication date: 11/29/2010
Series: Research and Perspectives in Alzheimer's Disease
Edition description: Softcover reprint of hardcover 1st ed. 2008
Pages: 183
Product dimensions: 6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Permanence of the synapse and molecular instability.- Cellular biology of AMPA receptor trafficking and synaptic plasticity.- Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo.- Synapse loss, synaptic plasticity and the postsynaptic density.- Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity.- Quantitative neuropathology in Alzheimer's mouse models.- Multiple levels of synaptic regulation by NMDA-type glutamate receptor in normal and disease states.- Soluble Oligomers of the Amyloid ß-Protein Impair Synaptic Plasticity and Behavior.- Why Alzheimer’s is a disease of memory: synaptic targeting by pathogenic Aß oligomers (ADDLs).- Synaptic transmission dynamically modulates interstitial fluid amyloid-b levels.- Aß-induced toxicity mediated by caspase cleavage of the amyloid precursor protein (APP).- Long-term potentiation and Aß: targeting Aß species, cellular mechanisms and putative receptors.- Genes, synapses and autism spectrum disorders.- Subject Index

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