Table of Contents
List of Contributors ix
Preface to Second Edition xvii
Preface the First Edition xix
Introduction 1
1 The Development of Clinical Trials 3 Simon Day
2 General Statistical Issues 13 David Machin
3 The Cochrane Collaboration 39 Mike Clarke
Cancer 47
4 Breast Cancer 49 Donald A. Berry, Terry L. Smith and Aman U. Buzdar
5 Childhood Cancer 63 Sharon B Murphy and Jonathan J.Shuster
6 Gastrointestinal Cancers 81 Daniel Sargent, Richard Goldberg and Paul Limburg
7 Melanoma 105 Ping-Yu Liu and Vernon K. Sondak
8 Respiratory Cancers 121 Joan H. Schiller and Kyungmann Kim
9 Adrenal Cortical Carcinoma 137 Isha Malik and Petros Perros
10 Thyroid Cancer 143 Vijayaraman Arutchelvam and Petros Perros
11 Urologic Cancers 149 Edith D. Canby-Hagino, Catherine M. Tangen, and Ian M. Thompson
12 Haematologic Cancers: Challenges in Developing New Therapeutic Approaches 167 Charles A. Schiffer and Stephen L. George
Cardiology 177
13 Acute Stroke 179 Philip Bath
14 Cardiovascular Disease 215 Krishna Prasad
Dentistry and Oral Health Care 241
15 Dentistry and Oral Health Care 243 May C.M. Wong, Colman McGrath and Edward C.M. Lo
Dermatology 261
16 Dermatology 263 Luigi Naldi and Cosetta Minelli
Infectious Diseases 287
17 HIV Infection 289 Michael D. Hughes
18 Infectious Diseases 303 Ingela Krantz
Ophthalmology 317
19 Ophthalmology 319 Jonathan C.K. Clarke and Peng-Tee Khaw
Psychiatry 333
20 Anxiety Disorders 335 M. Katherine Shear and Philip W. Lavori
21 Cognitive Behaviour Therapy 353 Nicholas Tarrier and Til Wykes
22 Psychotherapy for Depression 377 Graham Dunn
Reproductive Health 395
23 Contraception 397 Gilda Piaggio and Timothy M.M. Farley
24 Gynaecology and Infertility 421 Siladitya Bhattacharya and Jill Mollison
25 Early Pregnancy Termination 443 Beverly Winikoff and Batya Elul
26 Maternal and Perinatal Health 459 José Villar, Allan Donner, Edgardo Abalos and Liana Campódonico
Respiratory 475
27 Respiratory Medicine 477 Anders Källén
Surgery & Anaesthesia 517
28 Anaesthesia and Pain 519 Paul S. Myles and John Rigg
29 General Surgery 543 Dr Olga Jonasson and Domenic Reda
30 Plastic Surgery – Reconstructive Surgery 553 Erik Ang and Woffles Wu
31 Plastic Surgery – Aesthetic Surgery 575 Woffles Wu and Erik Ang
Transplantation 591
32 Renal Transplantation 593 Vathsala Anantharaman
Other Procedures 605
33 Wound Healing 607 Colin Song and Edwin Chan
34 Palliative Care 627 Robert S. Krouse and David Casarett
35 Complementary Medicine 647 Ping-Chung Leung
36 Cluster Randomized Trials in Health Care Research 669 Randall D. Cebul, Neal V. Dawson and Thomas E. Love
37 Nursing 681 Nicola Crichton
Special Populations 699
38 Clinical Trials in Paediatrics 701 Johan P.E. Karlberg
39 Clinical Trials Involving Older People 711 Carol Jagger and Antony J. Arthur
40 Clinical Trials in Rare Diseases 723 Simon Day
Index 735