The Dynamic Nature of Mitochondria: from Ultrastructure to Health and Disease

by Andreas S. Reichert (Editor)

Overview

Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature, controlling life at multiple levels. Mitochondria rule energy conversion, adapt cells well to changing stress and nutrient conditions, and regulate many cellular processes including immunity. The dynamic nature of mitochondria occurs at an intramitochondrial level but also includes its ability to interact with other organelles and to modulate multiple signalling pathways. It is thus not surprising that alterations or inabilities to ensure this dynamic behaviour is linked to ageing and human diseases.

The following'sections give an updated view on mitochondria:

• Mitochondrial ultrastructure: molecular mechanisms shaping the inner membrane
• Mitochondrial cristae and lipid dynamics: from super-resolution microscopy to lipid-OXPHOS interplay
• Mitochondrial control of cellular homeostasis: from redox signalling to interorganellar contact sites
• Mitochondria in health and disease: from mtDNA release to Complex I assembly
• Advanced methods in mitochondrial biology and metabolism research
• Integrative view on mitochondrial research and outlook

The field of mitochondrial research has always been full of surprises and has helped science to advance tremendously. It developed hand in hand with landmark developments in technology, such as super-resolution microscopy (nanoscopy), and is currently influencing an increasing number of scientific disciplines. There is still much ‘new’ to find out about this ‘old’ organelle and I think that you can find interesting and also unexpected aspects of mitochondrial biology in this book. I hope the book will enhance your scientific curiosity and inspire your own research.

Product Details

ISBN-13:	9781032117133
Publisher:	CRC Press
Publication date:	04/15/2024
Series:	Oxidative Stress and Disease
Pages:	210
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Andreas S. Reichert has been a Professor and Director of the Institute of Biochemistry and Molecular Biology I at the Heinrich-Heine University Düsseldorf, Germany since 2014. He’s been a board member of the Biologisch-Medizinisches Forschungszentrum (BMFZ) at Heinrich-Heine University Düsseldorf, Germany since 2016, and a speaker of BMFZ since 2021. Dr. Reichert received his Ph.D. under Prof. Dr. Svante Pääbo at the Institute of Zoology, Ludwig-Maximilians-Universität München, Germany in 1999, and was a Post-Doc under Prof. Dr. Svante Pääbo and Prof. Dr. Mario Mörl at the Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany from 1999-2000. As the Executive Director of the Center for Membrane Proteomics (CMP) at Goethe University Frankfurt am Main, from 2012-2014, Dr. Reichert simultaneously operated as a professor and Head of Mitochondrial Biology at Goethe University Frankfurt am Main, Germany.

Table of Contents

I. Mitochondrial ultrastructure – molecular mechanisms shaping the inner membrane. 1. Roles of the F₁F_O-ATP synthase and MICOS in mitochondrial membrane organization. 2. Proteolytic regulation of mitochondrial architecture. II. Mitochondrial cristae and lipid dynamics: from super-resolution microscopy to lipid-OXPHOS interplay. 3. Changes in cristae architecture and function: from static to dynamic. 4. Emerging roles of phospholipids in the structure and function of the Oxidative Phosphorylation complexes. III. Mitochondrial control of cellular homeostasis – from redox signaling to interorganellar contact-sites. 5. Mitochondrial Hydrogen Peroxide Dynamics. 6. Mitochondria-lysosome crosstalk, in disease and in health. IV. Mitochondria in health and disease: from mtDNA release to Complex I assembly. 7. mtDNA in & out - On the tightrope of cellular health. 8. Mitochondrial Complex I Assembly and Implications for Mitochondrial Disease. V. Advanced methods in mitochondrial biology and metabolism research. 9. The optogenetic landscape of the mitochondrion. VI. Integrative view on mitochondrial research and outlook. 10. Mitochondrial biology – a vibrating and dynamic research field still breaking boundaries.

Editorial Reviews

Reviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: Given rapid strides in the developments in the field of mitochondrial biology over the last 150 years, this book provides a conceptual change in the understanding of the dynamic nature of mitochondria and its biology. Understanding of the alterations in this dynamic behavior may be linked to ageing and human diseases. The book has several illustrations which facilitate better understanding of this complex information.
Purpose: The purpose of the book is to provide interesting and unexpected aspects of mitochondrial biology to scientists and researchers. These are indeed very worthy objectives, and the book is very much needed. The book meets the objectives as it nicely explains the dynamic nature of mitochondria from ultrastructure to health and disease.
Audience: The primary audience of the book is scientists and researchers. It will also appeal to biology students, teachers, scientists, researchers, and clinicians interested in mitochondrial biology in health and disease. The book meets the needs of the intended audience as it delves into providing an updated view on mitochondria and the conceptual change in the understanding of mitochondrial biology and mitochondrial dysfunction.
Features: The book contains five parts, with each part subdivided into two chapters. Part I deals with the Mitochondrial Ultrastructure with the Chapter 1 describing the intricate interplay of players such as OPA1, the F1F0 ATP synthase, and the MICOS complex and Chapter 2 covering interesting information related to regulation of mitochondrial ultrastructure by proteolysis and how the spatial distribution in different subcompartments adapt to changing conditions or stresses. Part II of the book deals with Mitochondrial Cristae and Lipid Dynamics with Chapter 3 covering changes in cristae architecture and function and Chapter 4 covering details of the emerging roles of the phospholipids and the lipid-OXYPHOS interplay. Part III of the book deals with Mitochondrial Control of Cellular Homeostasis with Chapter 5 providing coverage on the role of mitochondria in redox signaling and Chapter 6 covering important details into the complex interplay of mitochondria and lysosomes and their integration in different cellular functions. Part IV of the book deals with Mitochondria in Health and Disease with Chapter 7 describing about the role of mitochondria in regulating the innate immune response and interesting details about how mtDNA release and how they act as a mitochondrial damage-associated molecular pattern (DAMP) initiating inflammatory responses. Chapter 8 explains Mitochondrial Complex I Assembly and Implications for Mitochondrial Disease. Part V of the book deals with Advanced Methods in Mitochondrial Biology and Metabolism Research with Chapter 9 providing The Optogenetic Landscape of the Mitochondrion. Chapter 10, the last chapter of this book, provides some personal views of the author with the aim of providing a synopsis on the field of mitochondrial biology, its development over time, and potential future. The book includes a four-page index. A much more detailed Index would have been helpful to those trying to locate an interesting concept or topic in the book.
Assessment: This is an excellent book. The intended audience of the book including students, scientists, researchers, and clinicians will find this book highly useful. Comparative titles on this subject are available, but this book is quite unique in providing a conceptual change in the understanding of mitochondrial biology in health and disease over several decades.

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