Tissue Specificity and Autoimmunity

Tissue Specificity and Autoimmunity

by S. Shulman

Paperback(Softcover reprint of the original 1st ed. 1974)

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Product Details

ISBN-13: 9783642807985
Publisher: Springer Berlin Heidelberg
Publication date: 12/25/2011
Series: Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik , #16
Edition description: Softcover reprint of the original 1st ed. 1974
Pages: 197
Product dimensions: 6.69(w) x 9.61(h) x 0.02(d)

Table of Contents

1 Concepts of Specificity.- 2 The Thyroid Gland.- 1. Early Findings of Tissue Specificity and of the Protein Composition of Extracts.- 2. Purification of Thyroglobulin and other Thyroid Proteins; Problems of Heterogeneity and Instability.- a) Early Studies.- b) Fractionation by Chromatography—Early Approaches.- c) Fractionation by Ammonium Sulfate Precipitation: Thyralbumin and Thyroglobulin.- d) Fractionation by Centrifugation; Dissociation of Thyroglobulin.- e) Fractionation by Chromatography—Later Approaches; the Thyroid Family of Proteins.- f) Biochemical and Immunochemical Heterogeneity of Thyroglobulin.- 3. Subunit Structure of the Thyroglobulin Molecule.- 4. Detailed Studies of Thyroid Specificity.- a) The Species Distribution of Thyroid Antigens.- b) The Substance Responsible for Thyroid Specificity.- 5. The Formation of Autoantibodies.- a) Isoimmunization and Thyroiditis.- b) Autoantigenic Determinant Groups.- 3 The Adrenal Gland.- 1. Thermostable Antigens of Adrenal.- 2. Thermolabile Antigens of Adrenal.- 3. Experimental Adrenalitis.- 4. Human Adrenalitis.- 4 The Brain.- 1. The Several Brain-Specific Antigens.- 2. The Lipid Haptens.- a) Glycolipids as Normal Organ-Specific Haptens.- b) Gangliosides as Antigenic Markers of Disease.- 3. The Basic Proteins; Allergic Encephalomyelitis (AE).- a) Induction, Transfer, and Suppression of AE.- b) Chemical Nature of the Encephalitogenic Factor.- ?) Proteolipids and Collagen-Like Proteins.- ?) Basic Proteins.- c) Chemical Structures of the Encephalitogens.- d) Biological Properties of the Several Encephalitogen Molecules.- e) Diversity of Antigenic Determinants.- f) Relationship of AE to Human Disease.- 4. The Acidic Proteins.- 5. The Neutral Proteins.- 6. The Thermostable, Enthanol-Insoluble Proteins.- a) Antigenic Properties.- b) Chemical Properties.- 5 The Reproductive System.- 1. Spermatozoal and Testicular Antigens.- a) Experimental Aspermatogenesis.- b) Human Spermagglutinins.- 2. Antigens of the Male Accessory Glands of Reproduction..- a) Prostate Gland and Prostatic Fluid.- ?) Human Prostatic Fluid.- ?) Canine Prostatic Fluid.- ?) Rabbit Prostatic Tissues.- i) The Accessory Glands.- ii) Stimulation by Cryosurgery.- iii) The Antigens Shared with Seminal Plasma.- b) Seminal Plasma.- ?) Immunogenicity of Seminal Plasma.- ?) Composition of Human Seminal Plasma.- i) Physicochemical Properties.- ii) Antigenic Analysis.- c) Seminal Vesicular Fluid.- 3. Proteins and Antigens of the Female Reproductive Tract.- a) Uterine Fluid.- b) Tubal and Oviductal Fluids.- c) Cervical Mucus.- d) Maternal-Fetal Interactions.- 6 The Eye.- 1. Antigens of the Lens.- 2. Antigens of the Cornea.- 3. Antigens of the Uvea.- 4. Other Antigens of the Eye.- 7 The Kidney.- 1. The Experimental Production of Nephritis by Antiserum—Masugi Nephritis.- 2. The Antigens of the Glomerulus; the Nephrotoxic Antigens.- 3. The Antigens of the Tubule.- 4. The Formation of Autoantibodies Against Kidney Antigens.- a) Early Studies.- b) Isoimmunization in Rabbits and Rats by the Use of Streptococcal Adjuvants.- c) Isoimmunization in Rats by the Use of Freund’s Adjuvant.- d) Isoimmunization in Rabbits and Guinea Pigs by the Use of Freund’s Adjuvants.- 5. Experimental Glomerulonephritis.- a) Nephrotoxic Serum Nephritis.- b) Immune-Complex Nephritis.- c) Nephritis Following Injection of Kidney Components.- 6. Human Glomerulonephritis.- a) Antibodies to Kidney Antigens.- b) Streptococcal Antigens.- 8 Mechanisms of Immunopathology.- References.

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