Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology / Edition 1

by Sonia B. Jakowlew, M.B. Sporn

Overview

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-~ was first isolated and characterized as a dimeric pep­ tide from both human and bovine sources (1-3), but the entire fieldofTGF-~ research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-~ does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF-~can have disastrous consequences in almost all of these sites. Therefore, the present comprehensive review of so many aspects ofTGF-~ function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology.

Product Details

ISBN-13:	9781617377358
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/19/2010
Series:	Cancer Drug Discovery and Development
Edition description:	Softcover reprint of hardcover 1st ed. 2008
Pages:	735
Product dimensions:	0.00(w) x 0.00(h) x 0.39(d)

Table of Contents

Basic Concepts of TGF-β Signaling in Normal Physiology and Cancer Pathobiology.- Component Hardware for Transforming Growth Factor-β Signal Transduction: TGF-β Ligands, TGF-β Receptors, and Smads.- TGF-β Signaling in Homeostasis and Cancer.- TGF-β Availability: Latent TGF-β and Latent TGF-β Binding Proteins.- Biological Functions of Latent TGF-β-Binding Proteins and Activation of TGF-β.- Regulators of Smad2/3 Transcription and Phosphorylation.- Interaction of Smad4 and Embryonic Liver Fodrin-?-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression.- Regulation of Smad Activity by Phosphorylation.- Nuclear Targeting of TGF-β-Activated Smads in Normal and Tumor Biology.- Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival.- Transforming Growth Factor-β in Cancer Therapy: Smurfs in TGF-β Signaling and Regulation of Bone Homeostasis and Cancer.- Involvement of km23 Dynein Light Chains in TGF— Signaling.- TGF-β Signaling in Fibroblastic Cells and Oncogenesis.- Mechanisms of TGF-β-Induced Apoptosis in Cancer Cells.- Mechanisms of Cell Cycle Regulation by TGF-β Disabled in Cancer.- Transforming Growth Factor-β in Cancer Therapy.- TGF-β and Smad Signaling in Transcriptome Reprogramming During EMT.- Functional Interactions Between MMPs and TGF-β in Normal and Tumor Tissue.- Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function.- Interaction of Oncogenic Ras and TGF?1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model.- TGF-β Superfamily Members in Normal and Tumor Biology.- Proteomics Analysis of TGF? Superfamily Members.- Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain HumanCancers.- Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression.- Bone Morphogenic Proteins and Angiogenesis in Developing Tumors.- Histone Methyltransferase and Smad Interactions in BMP Signaling.- Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies.- Activins and Inhibins in Cancer Progression.- Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma.- Regulation of the Transforming Growth Factor-β Superfamily by Betaglycan.- Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney.- Role of Betaig-h3 Gene in Carcinogenesis.- Activins and the Liver.- Myostatin Signaling in Normal and Tumor Cells.- TGF-β in Inflammation and Fibrosis.- Triterpenoids, Vitamin D, and TGF-β/Smad Signaling in Inflammation and Cancer.- Thrombospondin-Dependent Activation of Latent TGF-β in Fibrosis and Disease.- TGF-β in Pulmonary Fibrosis.- The Role of TGF-β in Bleomycin Induced Pulmonary Fibrosis.- Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse.- TGF-β Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7.- Transforming Growth Factor-β Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema.- The Role of TGF-β in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-β as a Novel Therapeutic Strategy.- Negative Regulation of the TGF-β Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis.- TGF-β-Related Antifibrotic Strategies in the Eye.- Transforming Growth Factor-β in CutaneousTissue Repair.- Topical Application of TGF-β1 Peptide Inhibitors for the Therapy of Skin Fibrosis.- Overexpressed Truncated TGF-β Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo.

Editorial Reviews

From the reviews:

"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. … will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease … . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody’s Review Service, May, 2008)

From the Publisher

Reviewer: James P Luyendyk, Ph.D.(University of Kansas Medical Center)
Description: As a component of the Cancer Drug Discovery and Development series, this volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology.
Purpose: This first volume of a two-volume publication seeks to describe the current knowledge of the role of TGF-beta in biology and disease. This broad brush approach covers the molecular signaling induced by TGF-beta and the role of TGF-beta in cell biology and the pathogenesis of disease. The authors accomplish this through consolidation of a broad range of studies in a cohesive manner, making this a useful book.
Audience: This will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease and the rationale for the targeting of TGF-beta as a component of cancer treatment. This book will also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells.
Features: The book is divided into three sections, the first of which covers the fundamentals of TGF-beta biology, including the regulation and activation of the cytokine, its activation of intracellular signaling pathways, and its role in various cellular processes in cancer biology. Section two builds upon the basics in section one and describes the role of other TGF-beta superfamily members in cancer. Finally, the contribution of TGF-beta to inflammation and fibrosis in various organs/tissues is described. Importantly, this section builds upon the basic cell signaling described earlier. The figures and tables communicate the important features of TGF-beta signaling and avoid unnecessary complexity. One shortcoming is the lack of color in some of the histopathology figures.
Assessment: This book succeeds in describing the role of TGF-beta in basic cell biology and extends this discussion to include the clinical application of targeting TGF-beta in cancer and fibrosis. Complex signaling pathways are presented in a logical fashion, allowing readers to comprehend the more global role of TGF-beta in vivo.

Doody's Review Service