When Antidepressants Aren't Enough: Harnessing the Power of Mindfulness to Alleviate Depression

When Antidepressants Aren't Enough: Harnessing the Power of Mindfulness to Alleviate Depression

When Antidepressants Aren't Enough: Harnessing the Power of Mindfulness to Alleviate Depression

When Antidepressants Aren't Enough: Harnessing the Power of Mindfulness to Alleviate Depression


    Qualifies for Free Shipping
    Choose Expedited Shipping at checkout for delivery by Monday, February 26
    Check Availability at Nearby Stores

Related collections and offers


For nearly two decades, Dr. Stuart Eisendrath has been researching and teaching the therapeutic effects of mindfulness-based cognitive therapy (MBCT) with people experiencing clinical depression. By helping them recognize that they can find relief by changing how they relate to their thoughts, Eisendrath has seen dramatic improvements in people’s quality of life, as well as actual, measurable brain changes. Easily practiced breath exercises, meditations, and innovative visualizations release readers from what can often feel like the tyranny of their thoughts. Freedom of thought, feeling, and action is the life-altering result.

Product Details

ISBN-13: 9781608685974
Publisher: New World Library
Publication date: 10/01/2019
Pages: 224
Sales rank: 1,097,332
Product dimensions: 5.40(w) x 8.40(h) x 0.60(d)

About the Author

Stuart J. Eisendrath, MD, is a senior clinician and research psychiatrist at the University of California, San Francisco. The founding director of the UCSF Depression Center, he lives in San Francisco.

Read an Excerpt



Whether you call depression a demon, madness, or a season in hell, it is without doubt one of the most painful human conditions. It is also widespread, and younger and younger people are experiencing its onset. Instead of starting in a person's late twenties or thirties, as it once did, it now typically comes on in a person's late teens or early twenties. It also affects people of all social classes and situations. People as diverse as Abraham Lincoln, Winston Churchill, Ernest Hemingway, Brooke Shields, and Gwyneth Paltrow have suffered from depression.

Mahatma Gandhi described his depression as "a dryness of the heart" that made him want to "run away from the world." Vincent van Gogh described his experience in his diary: "I cannot possibly describe what the thing I have is like; there are terrible fits of anxiety — without any apparent cause — or then again a feeling of emptiness and fatigue in the mind. I consider the whole rather as a simple accident, no doubt a large part of it is my fault, and from time to time I have fits of melancholy, atrocious remorse."

If you have suffered from depression or are suffering right now, you know the sadness, the lack of joy, and the paralysis it can bring. It often impairs cognitive function, so that thinking and even the simplest decisions are difficult. The past looks terrible, the future promises disaster, and you may feel as if you are not worth much at all. Your sleep and appetite may be affected — either increased or decreased. You may be overcome with thoughts of death and suicide along with the feeling of being helpless to do anything about your condition. You may also feel hopeless, believing that no one else can help you. Here's what I want you to know right now: These thoughts are just that; they are thoughts. They are not facts. And I'm going to show you how to change your relationship to these thoughts, so they stop having such a firm grip on your life.

There are various theories about depression and what causes it. Currently, our understanding is that both genetic predispositions and environmental stressors play significant roles. There is some evidence, for instance, that genetic predispositions affect how we handle stress.

From an evolutionary standpoint, it has often been thought that depression has a potential adaptive function. For example, in studies of pigtail and bonnet macaque monkeys, when infants were separated from their mother, the infants adopted what appeared to be a depressive state. They would lie on the floor, curl up, and socially withdraw. After a short cry out to the mother, if the mother did not return, this depressive state persisted. So, in this sense, the depressive state was thought to act as a means of conserving energy.

Moreover, it was postulated that the infant monkeys would try to avoid such an apparently unpleasant state by staying close to their mother whenever possible. Thus, the attempt to prevent depressive states from occurring resulted in the enhancement of the drive for attachment of the infant to the mother. In this sense, avoidance of depression served as an adaptive survival value for the infants, keeping them safely attached and under the protective purview of their mothers.

The evolutionary hypothesis for depression is one of many that we consider today. Another causative factor is thought to be stress. The pace of everyday life has increased; coping with modern time pressures and information input can be challenging. An additional form of stress relates to our society's social fabric. As we've become a more mobile society, many of the established social supports, such as having family nearby, have dropped away. When these stresses are experienced along with traditional factors such as grief and trauma, the results are compounded. Biological factors such as genetics, neural transmitters, and brain circuitry also play key roles.

Our understanding of depression has been deepened in recent years by the investigation of brain functioning using moment-to- moment scanning such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). These techniques have revealed alterations of brain circuitry in people with depression and suggested that recovery may be associated with restoring more normal patterns of brain activation. These investigations have helped to shed light about what areas of the brain are most involved in depression and how interventions can be targeted toward those areas. For example, antidepressants and electrical or magnetic brain stimulation may be used to normalize altered patterns of activation. As we will discuss later, mindfulness interventions such as MBCT may have powerful brain impacts of their own.

Depression Is Not a One-Time Event

One thing we know for sure: depression tends to be chronic and recurrent. It is not a disease like pneumonia that happens once and then (usually) never happens again. It is more like asthma; you can expect to have episodes intermittently throughout your life. You must understand this vital point, so that when depressive episodes hit, you see them for what they are: recurrences of your illness and not personal weakness or moral failure.

With depression, the chance of having a recurrence increases with the number of episodes you've had. For example, with one episode, there is up to a 30 percent chance of recurrence within ten years. With three episodes, the likelihood of having a recurrence within that same time frame is 90 percent. The ability to "recover" from a depression does offer the best chance of preventing further episodes, and people can go for substantial periods of time without recurrence, but depression is not typically cured, and even in remission people may have lingering symptoms. Because of the likelihood of recurrence, I want you to have and know how to use the tools that MBCT can provide both to keep depression at bay and to deal with depressive symptoms when they arrive.

When depressive episodes hit, you must see them for what they are: recurrences of your illness and not personal weakness or moral failure.

But let's be clear. Although remission is often portrayed in rather glowing terms in pharmaceutical advertisements, it is not easily achieved. In fact, failure to achieve full remission shows the tenacity of your illness. It is typical, and it is not a personal weakness. Of course, not achieving remission occurs with other illnesses as well. Not many people achieve remission with medical conditions such as diabetes, hypertension, or chronic lung disease. Like depression, these illnesses tend to be chronic. That is why our modified MBCT approach is aimed at the illness rather than only a single episode.

The largest and longest study of depression ever completed at the National Institute of Mental Health, the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, investigated different approaches to depression treatment. In the study, the initial treatment consisted of administering a selective serotonin reuptake inhibitor (SSRI), the most commonly utilized class of antidepressant, for twelve weeks. The remission rate was 28 percent after this first treatment. If individuals did not achieve remission after that one antidepressant trial, they were given another antidepressant trial, an augmenting agent, or traditional cognitive therapy.

After this second step, the cumulative remission rate was approximately 50 percent. This meant, however, that half of the people had not achieved remission despite twenty-four weeks of monitored treatment in the study. After two additional twelve-week interventions (making a total of forty-eight weeks of treatment), only 43 percent of individuals were in remission, including participants who achieved remission but then suffered a relapse. These results illustrate the challenges facing those with depression.

This book is not written to denigrate antidepressants or traditional therapy. They can be lifesaving at times. But they have their limits, a point that applies to other forms of psychotherapy as well.

For example, for a number of years I taught cognitive therapy groups for individuals with chronic depression. In traditional cognitive therapy, negative thoughts (cognitions) are considered to be an important driver of depressed mood, and individuals are taught to challenge them. In this model when individuals express a negative belief or thought, they are encouraged to develop a more balanced or alternative thought. But this may be particularly difficult when individuals have suffered chronic depression lasting two or more years. Some people simply find it too difficult to counter their negative thoughts and beliefs.

If you have suffered depression for some time, I'm sure you get it. It is likely that you believe you have strong evidence to support your negative thoughts and beliefs due to many years of experience in interpreting yourself and your environment in a negative way. If you have been depressed for years (in our research, the Practicing Alternatives to Heal from Depression study, PATH-D, which is described in detail in Appendix A, participants averaged seven years of depression for their current episode), I'm sure you have accumulated quite a bit of evidence to support your pessimistic thinking. That's in large part because depression has a tendency to put a negative filter on memory and experiences. For example, if we have been rejected in one social situation, we typically expect further rejections, often blaming ourselves for the rejection. It's really hard to counter that with alternative thoughts.

Enter Mindfulness

The unique form of meditation that is mindfulness meditation offers a different approach. Other types, such as Transcendental Meditation and some forms of Judeo-Christian meditation, are concentrative; they focus on a particular phrase or word. Mindfulness meditation differs in that it is intentionally fixed on a focus the meditator chooses. For example, it may be focused on the breath moving in and out of the nostrils, bodily sensations, thoughts, or feelings. It allows meditators to observe themselves participating in experiences in real time, as those experiences are occurring. Mindfulness meditation is sometimes referred to as insight meditation, as it allows meditators to see things as they really are.

Mindfulness meditation traces its roots to Buddhist practices of twenty-five hundred years ago. The Buddha is said to have utilized his own mindfulness practices, including sitting and walking meditations. Over the centuries, mindfulness meditation has spread beyond its Asian beginnings. Modern mindfulness meditation can be traced to the Theravada tradition of Buddhism in the eighteenth century, where the meditative component of Buddhism was emphasized. In the mid-twentieth century Mahasi Sayadaw began to change the focus of meditation to center on a present-moment awareness of the sensations in the body, which is typically done through an exercise called the body scan. The mindfulness practice was further secularized and given a broader audience when Jon Kabat-Zinn introduced his Mindfulness-Based Stress Reduction (MBSR) program at the University of Massachusetts at Worcester in 1979, which was built around the principles he later elucidated in his classic book Full Catastrophe Living.

The MBSR program offered a way for a large number of people to explore mindfulness unhindered by religious or philosophical concepts. The program offered an eight-week course that facilitated empirical research regarding its efficacy. The program proved beneficial for a wide variety of conditions, such as chronic pain, heart disease, cancer, psoriasis, anxiety, and generalized stress. As a condensation of mindfulness practices into a discrete program, MBSR appealed to a wide-ranging audience. Importantly, it offered a platform that could be built upon for specific applications. In fact, it was the forerunner of the MBCT program as well as other mindfulness-based interventions. MBCT bears many similarities to MBSR, such as utilizing comparable meditation practices. MBCT differs by being more focused on depression and anxiety in contrast to MBSR's broader scope.

Mindfulness is focused on the present moment. You incline your mind to focus on something that is occurring right now. Often you may begin with focusing on the breath moving in and out, perhaps at the nostrils but at other times in the chest or abdomen. The breath is a neutral object of attention for most people and is always present during life. Breathing can be experienced with little thought or effort. It is naturally tied to the present moment — typically you don't spend much time focusing on your last breath or the upcoming one.

Many meditations start with the breath and then shift to another object of attention. For example, with the body scan, you typically start with the breath and then investigate the senses in areas of the body, starting in one limb and moving progressively throughout the body. But you do not need to begin with the breath in every meditation.

Mindfulness meditation is like a spotlight that you can choose to direct anywhere you want. It puts a bright light on the object of attention. You can aim it at physical sensations, but also at thoughts that are emerging or at feelings that are present. You can even choose "open awareness," in which you shine the spotlight on whatever arises in your consciousness. Although mindfulness meditation may be relaxing, it is aimed at producing awareness. In other words, it is aimed at falling awake, not asleep. But if you try a meditation and find yourself falling asleep, in keeping with the mindfulness approach you are to be accepting of that, not critical. Kindly self-compassion is central to mindfulness.

When you begin building your practice, several suggestions may be helpful. One is to use a quiet place where you won't be disturbed. Another is to build regularity into your practice by doing it at the same time each day. You can experiment with what time works best for you. Some people prefer to start their day with meditation, while others prefer it in the middle or at the end of the day. The meditative process is an empirical one — choose whatever you find most useful rather than what is recommended by the "authorities."

Without trying to change the thoughts and beliefs you have, mindfulness attempts to change your relationship to such thoughts. In this way, mindfulness approaches are sometimes termed metacognitive, because they pay attention to cognitive thought processes and not the thoughts themselves.

The metacognitive approach is key to how I work with people experiencing depression. Negative thoughts, beliefs, and feelings about oneself are very common in depression and are usually not valid — even the most firmly held beliefs. You may even be thinking this does not apply to you and that your negative thoughts are really accurate; we will take this up shortly.

As I mentioned in the Introduction, negative thoughts are not facts but rather symptoms of depression itself. For example, one young woman noted that whenever she felt depressed, she had the thought that no one cared about her. This depressive thought would escalate in intensity. When she emerged from depression, however, the thought diminished or disappeared. Clearly the thought was not a fact, but rather a symptom of her depression.

Vincent van Gogh, whose exact diagnosis remains imprecise, was thought to have had a mood disorder perhaps complicated by medication toxicity. About his depressive episodes he said, "During the actual crises it seemed to me that everything I was imagining was reality." After these episodes, he realized his thoughts were only transient products of his imagination — not facts.

Sometimes even therapists may not realize that such depressive thoughts are just mental events. For example, some individuals may castigate themselves after the death of a loved one: "If only I had gotten her to the doctor earlier," or "If only I had been home when he had his heart attack." Although in some instances it may be useful for a therapist to help a client unravel the origins of such guilty feelings, in the vast majority of situations this is a futile quest. It may be more useful to understand such guilty thoughts as symptoms of the depressive state itself.

In mindful approaches to depression, the key is not to find the origins of negative feelings, but to change your relationship to them, so they no longer have significant power in your life. When you find yourself feeling, "I am worthless," you will quickly be able to see that you are actually thinking, "I'm having the thought that I am worthless." You don't need to judge the validity of your thoughts, but rather just note them as transient mental events.

A classic Buddhist cautionary tale describes a warrior who was shot by an enemy with a poisoned arrow. Before allowing the arrow to be removed, he asked, "Why is this happening to me? Who did this? Did I deserve this?" Understanding the answers to these questions is of little value compared to treating the actual injury. Pursuing the question of why something happened may in fact lead to delay and death in such a case. On the other hand, noticing the thoughts and associated feelings in the present moment as passing mental events and then making a skillful response may be the most liberating approach, as we will soon see.


Excerpted from "When Antidepressants Aren't Enough"
by .
Copyright © 2019 Stuart J. Eisendrath.
Excerpted by permission of New World Library.
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.

Table of Contents

Foreword Zindel Segal, PhD xi

Introduction: When Antidepressants Aren't Enough 1

1 The Nature of the Depression Beast 11

Part I The Power of Now

2 What Mindfulness Is and What It Is Not 25

3 How Mindfulness Helps in Depression 49

Part II Changing Your Relationship to Your Mind and Thoughts

4 Your Mind Is Not Always Your Friend 67

5 Thoughts Are Not Facts: How to Befriend the Observing Self 79

Part 111 Stumbling Blocks to Change and How to Overcome Them

6 Anxiety: Depression's Frequent Partner 89

7 Anger and Its Impact on Depression 101

Part IV Lasting Ways to Achieve Happiness

8 Compassion and Self-Compassion: Antidotes for Anger and Allies in Combating Depression 113

9 Achievements Divided by Expectations Equals Happiness 127

10 The Difference between Pain and Suffering 141

11 Acceptance and Other Shifts in Attitude 149

12 How to Live Well Despite Depression: Keeping Your Practice Alive 167

Appendix A Clinical Research Results 175

Appendix B Research Results and Brain Effects 179

Acknowledgments 185

Permission Acknowledgments 187

Notes 189

Index 197

About the Author 207

From the B&N Reads Blog

Customer Reviews