Mass Spectrometry: Techniques for Structural Characterization of Glycans

Mass Spectrometry: Techniques for Structural Characterization of Glycans

by Michael A. Madson
Mass Spectrometry: Techniques for Structural Characterization of Glycans
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ISBN-10:
0128041293
ISBN-13:
9780128041291
Pub. Date:
05/16/2016
Publisher:
Elsevier Science
ISBN-10:
0128041293
ISBN-13:
9780128041291
Pub. Date:
05/16/2016
Publisher:
Elsevier Science
Mass Spectrometry: Techniques for Structural Characterization of Glycans

Mass Spectrometry: Techniques for Structural Characterization of Glycans

by Michael A. Madson

Overview

Mass Spectrometry: Techniques for the Structural Characterization of Glycans presents new methods for conducting detailed carbohydrate qualitative analysis—arming analytical chemists, pharmaceutical scientists, and food scientists with a quick reference that will allow them to determine the structures of carbohydrates molecules.

As there is a need in the scientific community for content specific to structural determination and analysis of new glycoprotein drug, and because structure-activity analysis requires a structural determination of the N- and O-linked oligosaccharides linked to glycol-proteins, this book provides the relevant research that are necessary for advances and new outcomes in this area of study.

Product Details

ISBN-13: 9780128041291
Publisher: Elsevier Science
Publication date: 05/16/2016
Pages: 86
Product dimensions: 6.00(w) x 9.00(h) x (d)

About the Author

Mike Madson is CEO and Senior Research Scientist of BioLogistics, LLC, Iowa, USA

Table of Contents

• Introduction• Monosaccharide Composition Analysis• Elemental Analysis of MS Ions• Derivatization Techniques• Hydride Addition to Sulfate and phosphate- Chemistry• InstrumentationMALDI-TOF MSAPI 2000 MSICP ESI TOF MS• Hydride Insertion Addition Reaction for the Derivatization of Phosphorylated or Sulfated Glycans and the Discernment of Phosphate versus Sulfate Esters• Ester Substitution MS MethodThe Protocol for the Hydride Addition to the ethanol extract of banana fruitExample of MS2on Hydride added to the ethanol Extract of Banana Fruit Glycan• Glycan Isolation Methods• Other Glycan isolation Methods• Monosaccharide AnalysisAcid Hydrolysis• Mass Spectral Carbohydrate Structure Determination MethodMSMS/MS (MS2)MSnProposing Initial Structure Refining Methods for Determining Exact Mass StructureMS Instrumentation Requirements for Discovering Whole Molecule IonsDerivatization Method and Sulfate/Phosphate Discernment Method• References

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This short-format reference presents new methods for conducting detailed carbohydrate qualitative analysis—arming analytical chemists, pharmaceutical scientists, and food scientists with a quick reference that will allow them to determine the structures of carbohydrate molecules, thus providing the relevant research necessary for advances in this area of study

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Related Subjects

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Science & Technology
Chemistry
Analytical Chemistry
Analytical Chemistry - General & Miscellaneous

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