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Handbook of Drug Interactions: A Clinical and Forensic Guide / Edition 1

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ISBN-10:: 1588292118
ISBN-13:: 9781588292117
Pub. Date:: 10/15/2003
Publisher:: Springer-Verlag New York, LLC

ISBN-10:: 1588292118
ISBN-13:: 9781588292117
Pub. Date:: 10/15/2003
Publisher:: Springer-Verlag New York, LLC

Handbook of Drug Interactions: A Clinical and Forensic Guide / Edition 1

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Overview

A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents.

Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

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Product Details

ISBN-13:	9781588292117
Publisher:	Springer-Verlag New York, LLC
Publication date:	10/15/2003
Series:	Forensic Science and Medicine
Edition description:	2004
Pages:	663
Product dimensions:	7.01(w) x 10.00(h) x 0.06(d)

1: Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cyhrome P450 3A4.- 2: Antiepileptic Drugs.- 3: Opioids and Opiates.- 4: Monoamine Oxidase Inhibitors and Tricyclic Antidepressants.- 5: Selective Serotonin Reuptake Inhibitors.- 6: Antipsychotic Drugs and Interactions: Implications for Criminal and Civil Litigation.- 7: Cardiovascular Drugs.- 8: Antimicrobial Drugs.- 9: Drug Interactions with Medications Used for HIV/AIDS.- 10: Nonsteroidal Antiinflammatory Drugs: Cyclooxygenase Inhibitors, Disease-Modiifying Antirheumatic Agents, and Drugs Used in Gout.- 11: Food and Drug Interactions.- 12: Alcohol and Drug Interactions.- 13: Nicotine and Tobacco.- 14: Anabolic Doping Agents.- 15: Drug Interaction Litigation.- 16: Psychotropic Medications and Crime: The Seasoning of the Prozac Defense.

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Editorial Reviews

4 Stars! from Doody

Reviewer: Melissa M. Potts, BS, PharmD (Temple University School of Pharmacy)
Description: This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective.
Purpose: This guide focuses on forensic medicine, where mechanisms of drug-drug interactions are emphasized. References to pharmacokinetic case studies describe drug interactions from a retrospective standpoint; drug levels and genotyping in these examples explain the potentially devastating consequences of drug-drug interactions. The very detailed information may be helpful to scientists and professionals searching for specific information on the mechanism of a drug-drug interaction. However, if a more clinical perspective is desired, this book may not be ideal.
Audience: Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. Perhaps laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. The book is well referenced and the toxicology studies help readers understand how drug interactions manifest in lethal drug levels, clinical effects, and patient outcomes.
Features: This book is unique in dedicating an entire chapter to drugs of abuse. Benzodiazepines, cocaine, marijuana, alcohol, and nicotine are included in this analysis and the book has detailed explanations of how these drugs interact with conventional medications. Pharmacokinetic and pharmacodynamic interactions are included, and tables and charts help readers to easily reference information. Well-designed studies on these illicit drugs are often difficult to find, so the book does an excellent job of thoroughly explaining drug interactions with these substances. Discussion of clinical manifestations and management of drug interactions is limited, but that is beyond the scope of this guide, which is truly focused on forensic analysis.
Assessment: The book thoroughly explains the mechanisms of drug-drug interactions, specifically highlighting the lethal consequences of these interactions with references to forensic case studies. From these examples, we can learn how drugs interact in the body and how certain patient genotypes can increase or decrease the risk of these interactions. Overall, this is a very interesting subject and the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.

Doody's Review Service

From the reviews of the second edition:
“This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective. … Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. … laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. … the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.” (Melissa M. Ranieri, Doody’s Book Reviews, March, 2012)

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