Handbook of Drug Interactions: A Clinical and Forensic Guide / Edition 1

by Ashraf Mozayani, Lionel Raymon

Overview

A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents.

Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

Product Details

ISBN-13:	9781617374241
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/09/2010
Series:	Forensic Science and Medicine
Edition description:	Softcover reprint of hardcover 1st ed. 2004
Pages:	663
Product dimensions:	7.01(w) x 10.00(h) x 0.05(d)

Table of Contents

Part I. Central Nervous System Drugs

Chapter 1: Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cyhrome P450 3A4

David E. Moody

Chapter 2: Antiepileptic Drugs

Nathan L. Kanous II and Barry E. Gidal

Chapter 3: Opioids and Opiates

Seyed-Adel Moallem, Kia Balali-Mood, and Mahdi Balali-Mood

Chapter 4: Monoamine Oxidase Inhibitors and Tricyclic Antidepressants

Terry J. Danielson

Chapter 5: Selective Serotonin Reuptake Inhibitors

Mojdeh Mozayani and Ashraf Mozayani

Chapter 6: Antipsychotic Drugs and Interactions: Implications for Criminal and Civil Litigation

Michael Welner

Part II. Cardiovascular Drugs

Chapter 7: Cardiovascular Drugs

Johann Auer

Part III. Antibiotics

Chapter 8: Antimicrobial Drugs

Amanda J. Jenkins and Jimmie L. Valentine

Chapter 9: Drug Interactions with Medications Used for HIV/AIDS

Michael Frank

Part IV. Nonsteroidal Antiinflammatory Drugs

Chapter 10: Nonsteroidal Antiinflammatory Drugs: Cyclooxygenase Inhibitors, Disease-Modifying Antirheumatic Agents, and Drugs Used in Gout

Imad K. Abukhalaf, Daniel A. von Deutsch, Mohamed A. Bayorh, and Robin R. Socci

Part V. Environmental and Social Pharmacology

Chapter 11: Food and Drug Interactions

Shahla M. Wunderlich

Chapter 12: Alcohol and Drug Interactions

A. Wayne Jones

Chapter 13: Nicotine and Tobacco

Edward J. Cone, Reginald V. Fant, and Jack E. Henningfield

Chapter 14: Anabolic Doping Agents

Daniel A. von Deutsch, Imad K. Abukhalaf, and Robin R. Socci

Part VI. Legal Aspects

Chapter 15: Drug Interaction Litigation

Stephen A. Brunette

Chapter 16: Psychotropic Medications and Crime: The Seasoning of the Prozac Defense

Michael Welner

Index

Editorial Reviews

4 Stars! from Doody

Reviewer: Melissa M. Potts, BS, PharmD (Temple University School of Pharmacy)
Description: This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective.
Purpose: This guide focuses on forensic medicine, where mechanisms of drug-drug interactions are emphasized. References to pharmacokinetic case studies describe drug interactions from a retrospective standpoint; drug levels and genotyping in these examples explain the potentially devastating consequences of drug-drug interactions. The very detailed information may be helpful to scientists and professionals searching for specific information on the mechanism of a drug-drug interaction. However, if a more clinical perspective is desired, this book may not be ideal.
Audience: Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. Perhaps laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. The book is well referenced and the toxicology studies help readers understand how drug interactions manifest in lethal drug levels, clinical effects, and patient outcomes.
Features: This book is unique in dedicating an entire chapter to drugs of abuse. Benzodiazepines, cocaine, marijuana, alcohol, and nicotine are included in this analysis and the book has detailed explanations of how these drugs interact with conventional medications. Pharmacokinetic and pharmacodynamic interactions are included, and tables and charts help readers to easily reference information. Well-designed studies on these illicit drugs are often difficult to find, so the book does an excellent job of thoroughly explaining drug interactions with these substances. Discussion of clinical manifestations and management of drug interactions is limited, but that is beyond the scope of this guide, which is truly focused on forensic analysis.
Assessment: The book thoroughly explains the mechanisms of drug-drug interactions, specifically highlighting the lethal consequences of these interactions with references to forensic case studies. From these examples, we can learn how drugs interact in the body and how certain patient genotypes can increase or decrease the risk of these interactions. Overall, this is a very interesting subject and the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.

Doody's Review Service

From the reviews of the second edition:

“This second edition outlines the most current information and highlights drugs of abuse while providing detailed information on the mechanisms of drug-drug interactions from a forensic toxicology perspective. … Any health or forensic professional could use this book to explain the underlying pharmacology of drug-drug interactions. … laboratory scientists conducting forensic analysis of drug interactions could use it to find thorough explanations of these interactions. … the book is an excellent reference for those professionals searching for underlying mechanisms of drug-drug interactions.” (Melissa M. Ranieri, Doody’s Book Reviews, March, 2012)

From the Publisher