Table of Contents

Contents

Participants

Preface

Acknowledgments

Section I. In Vitro Studies of Transfer Factor I

In Vitro Properties of Leukocyte Dialysates Containing Transfer Factor: Micro Method and Recent Findings

Specificity of Transfer Factor Action on Lymphocyte Transformation

In Vitro Comparison of TFDM Obtained from Skin Test Positive and Negative Individuals

Transfer Factor: In Vitro Effects on Lymphocyte Transformation

Augmentation of Lymphocyte Transformation by Dialysable Transfer Factor

Leukocyte Dialysates Require Precommitted, Antigen-Reactive Cells to Augment Lymphocyte Proliferation

Experimental Studies of Transfer Factor

Specific and Nonspecific Effects of Transfer Factor—Dialyzable Leukocyte Extracts

In Vitro Characterization of the Target Cell for Transfer Factor—Dialyzable Leukocyte Extracts

Section II. In Vitro Studies of Transfer Factor II

Acquisition of Mixed Cell Migration Reactivity by Actively Sensitized and Transfer-Factor Treated Rhesus Monkeys

In Vitro Assay for the Transfer Factor Using Direct Migration Inhibition

In Vitro Assay for Transfer Factor by Means of Leukocyte Migration Test (LMT)

Potentiating Effect of Transfer Factor upon Macrophage Migration Inhibition In Vitro

Effects of Dialyzable Transfer Factor on Accumulation of Cyclic Nucleotides by Leukocytes

Studies with In Vitro Produced Transfer Factor

Guinea Pig "Transfer Factor" In Vitro: Physico-Chemical Properties and Partial Purification

In Vitro Transfer of Coccidioidin and Histoplasmin Sensitivity to "Nonsensitive" Leukocytes Utilizing Whole Cell Lysates

Coccidioidin Sensitive Humans: Evidence of Cross Reactivity in a Transfer System

Production of Sheep Erythrocyte Rosette Forming Cells by Lymphocytes Cultured with Leucocyte Dialysates

Section III. Characterization of Transfer Factor

Identification of Hypoxanthine as the Major Component of Chromatographically Prepared Transfer Factor

Transfer Factor—Some Biochemical Observations

Quantitation of Transfer Factor

Some Physico-Chemical and Biological Properties of a Transfer Factor Preparation and Its Clinical Application

Use of Fluorescamine to Identify a Nonspecific Component of Human "Transfer Factor"

Studies on the Biological and Chemical Nature of a Component in Transfer Factor with Immunologically Nonspecific Activity

Demonstration of a Substance Chemically Similar to Human Transfer Factor in Lymphoid Cell Dialyzates from Several Animal Species

Chromatograph y of Transfer Factor and Assay of Fractions In Vitro

Fractionation of Rhesus Monkey Dialyzable KLH-Transfer Factor and the In Vitro Assay of Specific Biologic Activity Using the Indirect MIF Assay

Bovine Transfer Factor: Isolation and Characteristics

Biological Activity of Subfractions of Human Transfer Factor

Fractionation of Transfer Factor with High Pressure Liquid Chromatography and E-Rosette Enhancing Activity of Various Fractions

General Discussion

Section IV. Animal Models of Transfer Factor

Canine Transfer Factor

"Non-Specific" Effects of Human Dialyzable Transfer Factor

Transfer of Cellular Reactivity to 3 Nonhuman Primate Species with Human and Baboon Transfer Factor

Prevention of Herpes Simplex Virus Type I Fatal Dissemination in Primates with Human Transfer Factor

Transfer of Delayed Hypersensitivity to Mice with Human Immune Cell Extracts

Human Transfer Factor in Guinea Pigs: Further Studies

Human Transfer Factor in Guinea Pigs: Partial Purification of the Active Component

Human Transfer Factor: Trials with an Assay in Guinea Pigs

Correlation of In Vivo and In Vitro Activity of Guinea Pig Transfer Factor

Section V. Transfer Factor in Infectious Diseases

Transfer Factor Therapy of Chronic Aggressive Hepatitis

Attempted Immunotherapy with Dialyzable Transfer Factor in Hepatitis B Carrier Chimpanzees: Induction of Delayed Hypersensitivity to Hepatitis B Surface Antigen (HBsAg)

Transfer Factor Treatment of Viral Diseases in Milwaukee

Preliminary Results on the Safety and Efficacy of Transfer Factor in Leprosy

Clinical and Immunologie Results of Transfer Therapy in Coccidioidomycosis

Combination Transfer Factor-Amphotericin B Therapy in a Case of Chronic Mucocutaneous Candidiasis: A Controlled Study

Immunological Reconstitution of Chronic Mucocutaneous Candidiasis with Transfer Factor and Fetal Thymic Tissue

Transfer Factor Therapy of Disseminated Histoplasmosis

General Discussion

Section VI. Transfer Factor in Neoplastic Diseases

Transfer Factor Immunotherapy in Cancer

An Unusual Metastatic Lesion in a Patient with Osteosarcoma Receiving Tumor Specific Transfer Factor

Immunotherapy of Human Neoplasms with Transfer Factor

Adjunctive Transfer Factor in Osteogenic Sarcoma: I. Clinical Implications of Chemotherapy and Immunotherapy

Adjunctive Transfer Factor in Osteogenic Sarcoma: II. Methodology and Results of the Immunologic Studies

Transfer Factor Therapy in Disseminated Neoplasms

Clinical Trials with Transfer Factor

Section VII. Transfer Factor Treatment

The Role of Transfer Factor in the Treatment of Lymphoma Cutis in Wiskott-Aldrich Syndrome

Is the Clinical Benefit from Transfer Factor in Rheumatoid Arthritis a Placebo Effect?

The Effect of Chromatographically Purified Transfer Factor Component on Juvenile Rheumatoid Arthritis

Transfer Factor Immunotherapy of Rheumatoid Arthritis

Transfer Factor Therapy in a Patient with an Isolated T-Cell Deficiency

Effects of Transfer Factor in Waldenstrom's Macroglobulinemia and Multiple Myeloma

Treatment of a Child with Behcet's Syndrome with Transfer Factor

Transfer Factor Treatment of Patients with Multiple Sclerosis II. Immunological Parameters in a Long-Term Clinical Trial

Supplemental Papers

Transfer of Protective Immunity to Friend Leukemia Virus by Cell Free Extracts of Immune Lymphoid Cells

Leukapheresis of Cancer Patients for Adoptive Immunotherapy

Transfer Factor and Skin Grafts

On the Nature of Transfer Factor

Investigations of the Transfer of Cellular Immunity in Animal Model System by the Transfer Factor

Human "Transfer Factor" Activity in Guinea Pigs: Further Studies

Lymphocyte Antigen Sensitivity as a Requirement for a Blastogenic Response to Transfer Factor

Leishmania Enrietti Infections in Guinea Pigs and Transfer Factor Obtained from Convalescent yet Immune Animals

Clinical Evaluation of the Effects of Transfer Factor on Multiple Sclerosis

Section VIII. Keynote Address and Summation

A Biochemist's View of the Mediators of Cellular Immunity, with Special Reference to Transfer Factor

Summation

Subject Index