Transcriptome Profiling: Progress and Prospects

by Mohammad Ajmal Ali (Editor), Joongku Lee (Editor)

Overview

Transcriptome Profiling: Progress and Prospects assists readers in assessing and interpreting a large number of genes, up to and including an entire genome. It provides key insights into the latest tools and techniques used in transcriptomics and its relevant topics which can reveal a global snapshot of the complete RNA component of a cell at a given time. This snapshot, in turn, enables the distinction between different cell types, different disease states, and different time points during development. Transcriptome analysis has been a key area of biological inquiry for decades. The next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for multidimensional examinations of cellular transcriptomes in which high-throughput expression data are obtained at a single-base resolution. Transcriptome analysis has evolved from the detection of single RNA molecules to large-scale gene expression profiling and genome annotation initiatives. Written by a team of global experts, key topics in Transcriptome Profiling include transcriptome characterization, expression analysis of transcripts, transcriptome and gene regulation, transcriptome profiling and human health, medicinal plants transcriptomics, transcriptomics and genetic engineering, transcriptomics in agriculture, and phylotranscriptomics. - Presents recent development in the tools and techniques in transcriptomic characterization - Integrates expression analysis of transcripts and gene regulation - Includes the application of transcriptomics in human health, genetic engineering and agriculture

Product Details

ISBN-13:	9780323972314
Publisher:	Elsevier Science & Technology Books
Publication date:	10/07/2022
Sold by:	Barnes & Noble
Format:	eBook
Pages:	528
File size:	19 MB
Note:	This product may take a few minutes to download.

About the Author

Mohammad Ajmal Ali is an Associate Professor in the Department of Botany and Microbiology at King Saud University in Riyadh, Saudi Arabia, where he has taught molecular biology and bionanotechnology since 2010. He received his M.S. (1999) and Ph.D. (2006) degrees in Botany from TM Bhagalpur University in Bihar, India, and pursued postdoctoral research at Korea Research Institute of Biosciences and Biotechnology in Daejeon, South Korea. Ali's research program encompasses next-generation sequencing, computational chemistry, bioprospecting and bionanotechnology. He has authored/co-authored eight books and over 200 research articles in more than 52 journals of international repute.
Joongku Lee is a Professor in the Department of Environment and Forest Resources at Chungnam National University in Daejeon, South Korea. He received Ph.D. (1998) from the Department of Biology at SungKyunKwan University, South Korea. He conducted postdoctoral work at Jepson Herbarium and Department of Integrative Biology at the University of California, Berkeley, USA. Lee’s present research program encompasses next-generation sequencing, bioprospecting, and plant phylogeny. He has authored/co-authored 17 books and 171 publications.

Table of Contents

1. Transcriptomic Analysis of Gene Expression and Regulation2. Transcriptomics and genetic engineering3. Single cell transcriptomics4. Time course gene expression experiments5. Measurement and Meaning in Gene Expression Evolution6. G-quadruplexes as key motifs in Transcriptomics7. Spatial Transcriptomics8. Desert plant transcriptomics and adaptation to abiotic stress9. Transcriptomics in agricultural sciences: Capturing changes in gene regulation during abiotic or biotic stress10. Transcriptomics in context to biotic stress11. Functional genomics of biotic and abiotic stress responses in Capsicum12. Transcriptomic and epigenomic insights of chicken under heat stress13. Transcriptome Wide Identification of Immune Related Genes After Bacterial Infection in Fish14. Human transcriptome profiling: applications in health and disease15. Transcriptomics to devise human health and disease16. Transcriptomics and muscle pathologies17. Transcriptomics of Intracranial Aneurysms18. Recent advances in transcriptomic biomarker detection for cancer19. Future prospects of transcriptomics

What People are Saying About This

From the Publisher

Assesses the use of computational tools to effectively process sequence data in transcriptomics

Editorial Reviews

*4 stars* "This multi-author, edited volume takes a largely experimental approach to describing recent progress in transcriptome profiling, looking at both recent applications and future prospects. More than 80 authors contributed to this volume… and individual chapters take a research-oriented approach to the presentation of information. Several of the chapters could serve as a "how to" introduction to conducting transcriptome-based research in a given subject area,… a valuable objective and it is a credit to all involved in the book that this goal has been largely achieved…. [A] useful reference and practical guide to conducting transcriptome research. This book is a valuable addition to the field of transcriptomics and one that the target audience will find immensely useful.” —©Doody’s Review Service, 2023, Mark F. Sanders, PhD (UC Davis College of Biological Sciences)

From the Publisher

Reviewer: Mark Sanders, PhD (UC Davis College of Biological Sciences)
Description: The transcriptome is the complete set of messenger RNA transcripts present in a single cell or a group of cells. Transcriptome profiling is the collection of experimental processes that identify, assess, and interpret similarities and differences of transcriptome content of cells in different locations, under different circumstances, or at different points in time. This multi-author, edited volume takes a largely experimental approach to describing recent progress in transcriptome profiling, looking at both recent applications and future prospects.
Purpose: More than 80 authors contributed to this volume and the editors seem to have taken pains to ensure that the individual chapters take a research-oriented approach to the presentation of information. Several of the chapters could serve as a "how to" introduction to conducting transcriptome-based research in a given subject area. This is a valuable objective and it is a credit to all involved in the book that this goal has been largely achieved.
Audience: This book is intended for a research-oriented audience. Specifically, researchers in academic and commercial laboratories, post-doctoral researchers, medical researchers and advanced graduate students are the target audience. Users in each of these categories will find this book a useful reference and practical guide to conducting transcriptome research. The authors are each learned in the topics on which they write, and they have collectively provided an up-to-date and practical guide to transcriptome research.
Features: This book contains 19 chapters written by an international collection of more than 80 authors. The opening three chapters of the book give an overview of transcriptomics, and then describe transcriptomics and genetic engineering and transcriptomics of single cells. This is followed by a group of four chapters that describe spatial and temporal transcriptomics, the evolution of transcriptional variation, and key molecular motifs in transcription. Following these are six chapters on transcriptome studies in plants, fish, and chickens. A group of five chapters focuses on transcriptomic assessment in human health and disease, including muscle pathologies, aneurysms, and cancer. A chapter on future prospects completes the volume.
Assessment: Transcriptomics was first developed about 30 years ago and has advanced tremendously over those three decades. Advances in high-throughput RNA sequencing and bioinformatic data management have been especially important in the development of the field. Today, transcriptomics stands alongside genome sequencing as an essential partner in the "omic" exploration of genomes, genome variation, and the understanding of the consequences of genes and their expression on organisms. This book is a valuable addition to the field of transcriptomics and one that the target audience will find immensely useful.

Doody's Review Service