Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction

by DABCC Dasgupta Ph.D (Editor), PhD Sepulveda MD (Editor)

Overview

Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors.

• Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
• Includes new case studies that highlight clinical relevance and errors to avoid
• Highlights the best titles published within a variety of medical specialties
• Reviewed by medical librarians and content specialists, with key selections compiled in their annual list

Product Details

ISBN-13:	9780128137772
Publisher:	Elsevier Science
Publication date:	07/20/2019
Sold by:	Barnes & Noble
Format:	eBook
Pages:	510
File size:	31 MB
Note:	This product may take a few minutes to download.

About the Author

Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.

Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

Table of Contents

Section I: Sources of errors in clinical laboratories: An overview1. Variation, errors, and quality in the clinical laboratory2. Errors in patient preparation, specimen collection, anticoagulant and preservative use: how to avoid such pre-analytical errors3. Sample processing and specimen misidentification issues: major sources of pre-analytical errors4. Effect of patient-related factors on clinical laboratory test results5. Interferences of hemolysis, lipemia and high bilirubin on laboratory tests6. Immunoassay design7. Overview of other sources of interferences in immunoassays: prozone effect and interferences from heterophilic antibodies and autoantibodies8. Biotin interference in clinical laboratory tests: sporadic problem or a serious clinical issue? Section II: Sources of errors in clinical chemistry laboratory9. Challenges in routine clinical chemistry testing analysis of small molecules10. Challenges in routine clinical chemistry analysis: proteins and enzymes11. Challenges in endocrinology testing12. Pitfalls in testing for common tumor markers Section III: Sources of errors in therapeutic drug monitoring and toxicology13. Issues of interferences in therapeutic drug monitoring14. Limitations of immunoassays for screening of drugs of abuse in urine: issues of false positive and false negative results15. Challenges in confirmation testing for drugs of abuse16. Issues of false negative results in toxicology: difficult in detecting certain drugs and issues with detection of synthetic cathinone (bath salts), synthetic cannabinoids (spice), and other new psychoactive substances17. Ethanol determination using automated analyzers: limitations and pitfalls Section IV: Herbal medicines and laboratory testings18. Effects of herbal supplements on clinical laboratory test results Section V: Sources of errors in immunology laboratory19. Critical issues in hemoglobinopathy detection and serology testing for HIV and hepatitis infections20. Sources of errors in immunology and serology testing Section VI: Sources of errors in molecular, genetic and related testings21. Sources of error in molecular diagnostic analyses22. Molecular testing for targeted therapies and pharmacogenomics23. Challenges and sources of inaccuracy in biochemical genetics testing Section VII: Sources of errors in microbiology testings24. Sources of pre-analytical, analytical and post-analytical errors in the microbiology laboratory Section VIII: Sources of errors in hematology and coagulation testings25. Sources of errors in hematology testing26. Sources of errors in coagulation testing27. Sources of errors in flow cytometry Section IX: Sources of errors in transfusion medicine28. Interferences in blood bank testing29. Errors and adverse effects of blood transfusion30. Methodological issues in point of care testing devices31. Special concern: sources of inaccuracy in breath alcohol analysis

What People are Saying About This

From the Publisher

Practical, easy-to-use guide on interference issues across all types of clinical laboratory tests —- for both clinicians and clinical laboratory scientists

Editorial Reviews

"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation." —Reference and Research Book News, August 2013

"This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease." —Doody.com, August 9, 2013

From the Publisher