Advances in Cancer Research

by Kenneth D. Tew (Editor), Paul Fisher (Editor)

Overview

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Product Details

ISBN-13:	9780124072114
Publisher:	Elsevier Science & Technology Books
Publication date:	12/02/2012
Series:	Advances in Cancer Research , #119
Sold by:	Barnes & Noble
Format:	eBook
Pages:	504
File size:	7 MB

About the Author

Professor & Chairman, Dept of Cell & Molecular Pharmacology John C. West Chair of Cancer Research, Medical University of South Carolina, USA

The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.

Table of Contents

1. Unconventional approaches to modulating the immunogenicity of tumor cellsPaul Dent2. Tumor dormancy and immunoeditingMasoud H. Manjili3. Emerging role of anti-apoptotic Bcl-2 family proteins in chemoresistanceRupesh Dash4. Beclin-1 and AutophagyPaul Fisher5. Nanotechnology and MedicineRajagopal Ramesh6. PENDING TITLEMonica Valentovic

What People are Saying About This

From the Publisher

This comprehensive guide provides invaluable information on the exciting and fast-moving field of cancer research that includes outstanding and original reviews on a variety of topics

Editorial Reviews

Praise for the Serial
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." —American Scientist

"Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." —Journal of Medicinal Chemistry

"This is a series that has a long tradition of excellence in the field of cancer biology." —Doody’s Publishing Reviews

From the Publisher