Biomedical Optical Imaging

by James G. Fujimoto, Daniel Farkas

Overview

Contributions from leading international research groups provide a comprehensive view of the major areas of biomedical optical imaging ranging from the microscopic to the macroscopic and fundamental to clinical applications.

Product Details

ISBN-13:	9780199722297
Publisher:	Oxford University Press
Publication date:	04/22/2009
Sold by:	Barnes & Noble
Format:	eBook
File size:	8 MB

About the Author

James G. Fujimoto is Professor of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology, where he works on the development and application of femtosecond laser technology and studies ultrafast phenomena and biomedical optics. He received his bachelors, masters, and doctorate degrees from M.I.T.

Books by the Same Author/Editor:
Optical Coherence Tomography of Ocular Diseases |a C. A. Puliafito, M. R. Hee, J. S. Schumann and J. G. Fujimoto
Ultrafast Phenomena X |a P. F. Barbara, J. G. Fujimoto, W. H. Know and W. Zinth
Ultrafast Phenomena XI |a T. Elsaesser, J. Fujimoto, D. Wiersma and W. Zinth
Optical Coherence Tomography of Ocular Diseases, 2nd edition |a J. S. Schuman, C. A. Puliafito and J. G. Fujimoto
Everyday OCT: A Handbook for Clinicians and Technicians |a J. S. Schuman, C. A. Puliafito and J. G. Fujimoto

Daniel Farkas is Vice Chairman for Research in the Department of Surgery and Director of the Minimally Invasive Surgical Technologies Institute at the Cedars-Sinai Medical Center in Los Angeles. He is also a Research Professor in Biomedical Engineering at the University of Southern California, and Adjunct Professor at the Robotics Institute at Carnegie Mellon University. Farkas was trained in theoretical physics in Romania, and holds a Ph.D. in Biophysics and Biochemistry from the Weizmann Institute in Israel.

Books by the Same Author/Editor:
Optical Diagnostics of Living Cells and Biofluids, Progress in Biomedical Optics, Vol. 2678 |a T. Asakura, D. L. Farkas, R. Leif and A. V. Priezzhev
Functional Imaging and Optical Manipulation of Living Cells and Tissues, Progress in Biomedical Optics, Vol. 2983 |a D. L. Farkas and B. J. Tromberg
Optical Investigations of Biological Systems In Vitro and In Vivo, Progress in Biomedical Optics, Vol. 3260 |a D. L. Farkas, R. Leif and B. J. Tromberg
Manipulation by Light in Biology and Medicine: The Laser Microbeam and Optical Tweezers, Enabling Techniques in Bioimaging |a Karl Otto Greulich and D. L. Farkas (editor)
Optical Diagnostics of Living Cells II, Progress in Biomedical Optics, Vol. 3604 |a D. L. Farkas, R. C. Leif and B. J. Tromberg
Optical Diagnostics of Living Cells III, Progress in Biomedical Optics, Vol. 3921 |a D. L. Farkas and R. C. Leif
Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine, Methods in Bioengineering |a J. Huard, F. Fu and D. L. Farkas (editor)
Optical Diagnostics of Living Cells IV, Progress in Biomedical Optics, Vol. 4260 |a D. L. Farkas and R. C. Leif
Optical Diagnostics of Living Cells V, Progress in Biomedical Optics and Imaging, Vol. 4622 |a D. L. Farkas and R. C. Leif
Manipulation and Analysis of Biomolecules, Cells and Tissues I, Progress in Biomedical Optics and Imaging, vol. 4962 |a D. Nicolau, J. Enderlein, R. C. Leif and D. L. Farkas
Manipulation and Analysis of Biomolecules, Cells and Tissues II, Progress in Biomedical Optics and Imaging, Vol. 5322 |a D. Nicolau, J. Enderlein, R. C. Leif and D. L. Farkas
Imaing, Manipulation and Analysis of Biomolecules, Cells and Tissues III, Progress in Biomedical Optics and Imaging, Vol. 5699 |a D. Nicolau, J. Enderlein, R. C. Leif, D. L. Farkas and R. Raghavachari
Imaging, Manipulation and Analysis of Biomolecules, Cells and Tissues IV, Progress in Biomedical Optics and Imaging, Vol. 6088
Imaging, Manipulation and Analysis of Biomolecules, Cells and Tissues, Progress in Biomedical Optics and Imaging, Vol. 6441 |a D. L. Farkas, D. Nicolau and R. C. Leif

Table of Contents

Contributors xi

1 Confocal Microscopy Tony Wilson 3

2 Spectral Optical Imaging in Biology and Medicine Kevin Burton Jihoon Jeong Sebastian Wachsmann-Hogiu Daniel L. Farkas 29

3 Multiphoton Microscopy in Neuroscience Fritjof Helmchen Samuel S.-H. Wang Winfried Denk 73

4 Messenger RNA Imaging in Living Cells for Biomedical Research Dahlene Fusco Edouard Bertrand Robert H. Singer 102

5 Building New Fluorescent Probes Alan S. Waggoner Lauren A. Ernst Byron Ballou 120

6 Imaging Membrane Potential with Voltage-Sensitive Dyes Dejan Vucinic Efstratios Kosmidis Chun X. Falk Lawrence B. Cohen Leslie M. Loew Maja Djurisic Dejan Zecevic 132

7 Biomedical Imaging Using Optical Coherence Tomography James G. Fujimoto Yu Chen Aaron Aguirre 161

8 Two-Photon Fluorescence Correlation Spectroscopy Petra Schwille Katrin Heinze Petra Dittrich Elke Haustein 196

9 Nanoscopy: The Future of Optical Microscopy Stefan W. Hell Andreas Schönle 237

10 Fluorescence Imaging in Medical Diagnostics Stefan Andersson-Engels Katarina Svanberg Sune Svanberg 265

11 Flurescence and Spectroscopic Markers of Cervical Neoplasia Ina Pavlova Rebekah Drezek Sung Chang Dizem Arifler Konstantin Sokolov Calum MacAulay Michele Follen Rebecca Richards-Kortum 306

12 Quantitative Absorption and Scattering Spectra in Thick Tissues Using Broadband Diffuse Optical Spectroscopy Dorota Jakubowski Frederic Bevilacqua Sean Merritt Albert Cerussi Bruce J. Tromberg 330

13 Detection of Brain Activity by Near-Infrared Light Enrico Gratton Vlad Toronov Ursula Wolf Martin Wolf 356

14 In Vivo Optical Imaging of Molecular Function Using Near-Infrared Fluorescent Probes Vasilis Ntziachristos Ralph Weissleder 374

15 Revealing the Subtleties of Disease and the Nuances of the Therapeutic Response with Optical Reporter Genes Christopher H. Contag 397

Index 411