Biotechnology and Bioactive Polymers / Edition 1

by Charles E. Carraher Jr., C.G. Gebelein

Overview

Some have predicted that the coming several decades will be the decades of "biotechnology," wherein cancer, birth defects, life span increases, cosmetics, biodegradation, oil spills and exploration, solid waste disposal, and almost every aspect of our material life will be affected by this new area of science. There will also be an extension of emphasis on giant molecules: DNA, enzymes, polysaccharides, lignins, proteins, hemoglobin, and many others. Biotechnology has been defined in various ways. In one sense, this field is older than human history and references to the human use of biotechnology-derived materials can be found in the oldest human writings, such as the Bible. In this book, biotechnology refers to the direct usage of naturally occurring materials or their uses as a feedsk, including the associated biological activities and applications of these materials. Bioactive polymers, on the other hand, are polymers which exert some type of activity on living organisms. These polymers are used in agriculture, controlled release systems, medicine and many other areas. The papers in this book describe polymers which essentially combine features of biotechnology and bioactivity.

Product Details

ISBN-13:	9780306446290
Publisher:	Springer US
Publication date:	02/28/1994
Edition description:	1994
Pages:	342
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

About the Author

Gebelein, Charles G. (Florida Atlantic Univ); Carraher, Charles E., Jr. (Florida Atlantic Univ)

The book is a collection of papers delivered at the International Symposium on Biotechnology and Bioactive Polymers presented at the spring 1992 American Chemical Society Meeting in San Francisco. Five separate biomedical companies provided partial financial support of the symposium.

Table of Contents

Section 1: Polysaccharide Applications.- Factors Affecting the Bacterial Activity of Saccharides and Polysaccharides Modified Through Reaction With Organostannanes.- Acetan — A New Bacterial Polysaccharide.- Coagulation Properties of Chemically Modified Heparins.- Hylan Gel for Soft Tissue Augmentation.- Adsorption of Metal Ions on Chitosan and Chemically Modified Chitosan and Their Application to Hydrometallurgy.- Chitin and Chitosan: Ecologically Bioactive Polymers.- Recovery of Proteins From Whey Using Chitosan As a Coagulant.- Use of Lignin-Based Materials in the Selective Inhibition of Microorganisms.- Section 2: Polypeptides and Biodegradable Polymers.- Living Polymerization of Proteins: Actin and Tubulin. A Review.- Cell Adhesive Properties of Bioelastic Materials Containing Cell Attachment Sequences.- Expression of a Synthetic Mussel Adhesive Protein in Escherichia coli.- Experiences With Collagen-Derived Biomaterials in Research and Treatment of Humans.- Modulation of Phosphocholine Bilayer Structures.- Special Functional Group Triglyceride Oil Based Interpenetrating Polymer Networks.- Biodegradable Polymers in the Environment: Are They Really Biodegradable?.- Four Year Absorption Study of Three Morphologically Different Forms of Poly-L-Lactide in Rabbits.- Section 3: Medical Diagnostic Applications.- Non-Aqueous Polymeric Systems (NAPS) for Diagnostic Applications.- Protein Purification by Selective Adsorption on Immobilized Pyridinium Ligands.- Moldable Dry Chemistry.- Preparation of Bacterial Adsorption Polymer and Its Application to Biosensors.- Immobilization of Adenosines on Silica Gel and Specific Separation of Thymidine Oligomers.- Section 4: Controlled Release and Medicinal Applications.- Advances in Antimicrobial Polymers and Materials.- Developmentof Polymeric Beta-Lactam Systems — Synthetic Study and Characterization.- Biodegradable Polymers for the Controlled Delivery of Vaccines.- Strategies for Treating Arterial Restenosis Using Polymeric Controlled Release Implants.- The Use of PolyICLC in the Treatment of AIDS.- The Release of 5-Fluorouracil From Dextran and Xylan Systems.- Release Behavior of 5-Fluorouracil From Chitosan-Gel Microspheres Modified Chemically and Their Antitumor Activities.- Biologically Active Polyphosphate and Polyphosphonate Esters — Nucleic Acid Analogs.- The Controlled Release of a 5-Fluorouracil Prodrug From a Biodegradable Matrix.- Novel Antiinfective Biomaterials by Polymer Modification.- Contributors.

Editorial Reviews

Reviewer: Kevin E. Healy(Northwestern University)
Description: The book attempts to present polymers that use aspects of biotechnology either in their synthesis or ultimate application. The book is a unique contribution from a combined American Chemical Society symposium sponsored by the Biotechnology Secretariat and the Division of Polymeric Materials.
Purpose: The focus is to describe polymers that essentially combine features of biotechnology and bioactivity. This book represents a much-needed contribution from an interdisciplinary group of researchers and should be well accepted, although the circulation may not be particularly great. The book meets the authors' objectives; however, in many chapters, the materials invoke biotechnology, but not bioactivity, or the converse. The title may overstate the contents of the text.
Audience: This book is targeted toward advanced graduate and postdoctoral students as well as the basic and applied scientist. The authors are clearly experts in their fields, and the work presented reflects significant progress compared with previously published works. The audience may encompass a wide diversity of disciplines, spanning materials science of native (i.e., biologically derived) or synthetic polymers, to cell biology.
Features: The format is consistent throughout the text. All figures and tables seem appropriate, although some figures appear upside down when viewed with the text in a normal reading position. The unique feature is the diverse nature of the contributions from researchers in disparate fields addressing common themes. Breadth of this type only comes from jointly sponsored symposia.
Assessment: The scientific quality of this book is high. It seems that researchers both at the symposium and others unable to attend would appreciate this text. However, the material presented in the text may be outdated, because the symposium took place two years ago.

Doody's Review Service

4 Stars! from Doody

The book attempts to present polymers that use aspects of biotechnology either in their synthesis or ultimate application. The book is a unique contribution from a combined American Chemical Society symposium sponsored by the Biotechnology Secretariat and the Division of Polymeric Materials. The focus is to describe polymers that essentially combine features of biotechnology and bioactivity. This book represents a much-needed contribution from an interdisciplinary group of researchers and should be well accepted, although the circulation may not be particularly great. The book meets the authors' objectives; however, in many chapters, the materials invoke biotechnology, but not bioactivity, or the converse. The title may overstate the contents of the text. This book is targeted toward advanced graduate and postdoctoral students as well as the basic and applied scientist. The authors are clearly experts in their fields, and the work presented reflects significant progress compared with previously published works. The audience may encompass a wide diversity of disciplines, spanning materials science of native (i.e., biologically derived) or synthetic polymers, to cell biology. The format is consistent throughout the text. All figures and tables seem appropriate, although some figures appear upside down when viewed with the text in a normal reading position. The unique feature is the diverse nature of the contributions from researchers in disparate fields addressing common themes. Breadth of this type only comes from jointly sponsored symposia. The scientific quality of this book is high. It seems that researchers both at the symposium and others unable to attend would appreciate this text.However, the material presented in the text may be outdated, because the symposium took place two years ago.

Kevin E. Healy

Examines polymers that exert some kind of influence on living organisms, and their use in biotechnological applications in a number of fields. Among the topics are hylan gel for soft tissue augmentation, the modulation of phosphocholine bilayer structures, the preparation of bacterial adsorption polymer and its application to biosensors, and novel anti-infection biomaterials by polymer modification. The 31 papers are from a symposium in San Francisco, April 1992. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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