Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer / Edition 1

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer / Edition 1

ISBN-10:
0471710962
ISBN-13:
9780471710967
Pub. Date:
08/23/2011
Publisher:
Wiley

Hardcover

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Overview

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer / Edition 1

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Product Details

ISBN-13: 9780471710967
Publisher: Wiley
Publication date: 08/23/2011
Pages: 436
Product dimensions: 6.30(w) x 9.30(h) x 1.10(d)

About the Author

Antonio Giordano, M.D., Ph. D., is professor of biology andmedical research at Temple University College of Science andTechnology in Philadelphia, Pennsylvania. In 1993 he co-founded theSbarro Institute for Cancer Research and Molecular Medicine. He hasbeen honored as Knight by the president of Italy and is recipientof the National Italian-American Political Action Committee(NIA-PAC) National Lifetime Achievement Award in Medical Research.

Marcella Macaluso, Ph.D., is associate professor ofbiology and a researcher in the Hormone-Signaling and CancerProgram of the Sbarro Institute for Cancer Research at TempleUniversity in Philadelphia.

Table of Contents

Contributors.

Preface.

SECTION I: EPIGENETICS AND CELL CYCLE.

1 Epigenetic Modulation of Cell Cycle: An Overview (MicaelaMontanari, Antonio Giordano, Marcella Cintorino, and MarcellaMacaluso).

SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE ANDDIFFERENTIATION.

2 Epigenetics in Skeletal Muscle Development (CristinaGiacinti and Antonio Giordano).

3 Epigenetic Control in Cellular Senescence (Heike Helmbold,Wolfgang Deppert, and Wolfgang Bohn).

4 Epigenetic Modulation in Cell Development and Differentiation(Mario Mancino, Claudia Esposito, Raffaella Pasquale, ImmacolataVocca, and Francesca Pentimalli).

SECTION III: EPIGENETICS AND GENE TRANSCRIPTION.

5 Epigenetic Control of Gene Transcription (ChristianBronner, Mayada Achour, Thierry Chataigneau,and Valerie B.Schini-Kerth).

6 Epigenetics, MicroRNAs, and Cancer: An Update (GiuseppeRusso, Andrew Puca, Francesco Masulli, Stefano Rovetta,LetiziaCito, Debora Muresu, Flavio Rizzolio, and AntonioGiordano).

SECTION IV: EPIGENETICS AND CANCER.

7 The Role of Epigenetic Modifications in Cancer (Michael J.Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,AlexanderMazo, and Richard G. Pestell).

8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, andOther Diseases (Serena Buontempo, Mara Sannai, and AlfonsoBellacosa).

9 Epigenetics in Pediatric Cancers (Roberta Ciarapica,Lavinia Raimondi, Federica Verginelli, and Rossella Rota).

10 Epigenetic Mechanisms in Cancer Formation and Progression(Elisabetta Fratta, Luca Sigalotti, Alessia Covre, GiuliaParisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral,and Michele Maio).

SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT ANDTHERAPY.

11 Recent Advances in the Field of Stem Cell Research: Towardthe Definition of the Epigenetic and Genetic Codes of Pluripotency(Gaetano Romano).

12 Potential of Heat Shock Protein Targeting for Human Therapy(Laszlo Otvos, Jr).

13 Advances in Stem Cell Therapy for Cancer Research (AndrewPuca and Antonio Giordano).

14 Epigenetic Targets and Drug Development (ParaskeviVogiatzi, Maria Irene Scarano, and Pier Paolo Claudio).

Index.

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