Cellular and Molecular Neurophysiology

by Constance Hammond PhD

Overview

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. - 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations - Fifteen appendices describing neurobiological techniques are interspersed in the text

Product Details

ISBN-13:	9780123973221
Publisher:	Elsevier Science & Technology Books
Publication date:	12/30/2014
Sold by:	Barnes & Noble
Format:	eBook
Pages:	444
File size:	28 MB
Note:	This product may take a few minutes to download.

About the Author

Constance Hammond is an INSERM director of research at the Mediterranean Institute of Neurobiology. A renowned Parkinson's disease investigator, in 2012 she became a Chevalier of the Légion d'Honneur in recognition for her services to scientific communication. Studying biology at the University of Pierre and Marie Curie and the Ecole Normale Supérieure in Paris she completed her thesis in neurosciences at the Marey Institute in Paris, directed by Prof. D. Albe-Fessard. Guided by her curiosity and her constant desire to learn, she changed lab and research domains several times. With the knowledge of other systems and the mastering of other techniques she finally came back to her first and preferred subject of research; the role of the subthalamic nucleus in the basal ganglia system in health and Parkinson's disease.

Table of Contents

Part I. Neurons: Excitable and Secretory Cells That Establish Synapses1. Neurons2. Neuron – Glial Cell Cooperation3. Ionic Gradients, Membrane Potential and Ionic Currents4. The Voltage-Gated Channels of Na+ Action Potentials5. The Voltage-Gated Channels of Ca+2 Action Potentials: Generalization6. The Chemical Synapses7. Neurotransmitter Release Part II. Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction8. The Ionotropic Nicotinic Acetycholine Receptors9. The Ionotropic GABAA Receptor10. The Ionotropic Glutamate Receptors11. The Metabotropic GABAB Receptors12. The Metabotropic Glutamate Receptors Part III. Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials13. Somato-Dendritic Processing of Postsynaptic Potentials I: Passive Properties of Dendrites14. Subliminal Voltage-Gated Currents of the Somato-Dendritic Membrane15. Somato-Dendritic Processing of Postsynaptic Potentials II: Role of Subthreshold Depolarizing Voltage-Gated Currents16. Somato-Dendritic Processing of Postsynaptic Potentials III: Role of High Voltage-Activated Depolarizing Currents17. Firing Patterns of Neurons18. Synaptic Plasticity Part IV. The Adult Hippocampal Network19. The Adult Hippocampal Network20. Maturation of the Hippocampal Network

What People are Saying About This

From the Publisher

Tutorial reference for neurophysiologists and students on the molecular and cellular physiology of neurons and synapses

Editorial Reviews

"In its third internationally acclaimed edition, this textbook provides an unrivaled account of the basic foundations of molecular and cellular neurophysiology. For those of us who were inclined to believe that the unprecedented development of neuroscience made neurophysiology disposable, Constance Hammond proves us with conviction and elegance that this is just not the case!"-Dr. Robert Dantzer, Professor of Psychoneuroimmunology, Integrative Immunology and Behavior Program University of Illinois at Urbana-Champaign "Unlike many other texts, chapters in this book are structured around the known neurophysiological facts. The author states the fact, gives simple explanations for why it is so, and when appropriate follows her discussion by in-depth analyses. Also unlike many other texts, the chapters are not built around the work of other people, and are not overburdened with references to published material. This style makes for a very fluid and self consistent read which should be of interest to neophytes and advanced students alike."-Jean-Marc Fellous, Professor Psychology, Neuroscience, Cognitive Sciences, and Applied Mathematics, University of Arizona, Tucson "A particularly strong feature of the book is that most of the exposition is driven by data from original experiments, supplying many figures that offer a ready-made basis for lectures (figures are available on the instructor's website). In addition, appendices of many chapters provide further information about techniques or related topics (e.g. patch-clamping, fluorescence measurements, neurotransmitter identification) that is often not essential to understanding the physiology, but is extremely useful to the more interested or advanced student."-Jim Belanger, Department of Biology, West Virginia University "More than any similar volume that I have come across in recent years, this one has the potential of luring students of neuroscience and even students from other fields to build a career in neurophysiology."-György Buzsáki, M.D., Ph.D., Board of Governors Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University "Constance Hammond has rewritten and updated most of the chapters, which gives a better homogeneity to the book. The figures are now in color and thereby easier to read. In summary, this book is a very precious and unique tool, ideal for students with a strong interest in neuroscience." -Jean-Francois Perrier, Institute of Neuroscience and Pharmacology, University of Copenhagen, Denmark "This is an outstanding book that I will definitely recommend to my students." -Peter Somogyi, Oxford University, United Kingdom

From the Publisher