Cellular and Molecular Neurophysiology / Edition 4

by Constance Hammond

Overview

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.

This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field

This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology.

• 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations
• Fifteen appendices describing neurobiological techniques are interspersed in the text

Product Details

ISBN-13:	9780123970329
Publisher:	Elsevier Science
Publication date:	01/20/2015
Edition description:	New Edition
Pages:	444
Product dimensions:	8.50(w) x 11.00(h) x 1.10(d)

About the Author

Constance Hammond is an INSERM director of research at the Mediterranean Institute of Neurobiology. A renowned Parkinson's disease investigator, in 2012 she became a Chevalier of the Légion d'Honneur in recognition for her services to scientific communication. Studying biology at the University of Pierre and Marie Curie and the Ecole Normale Supérieure in Paris she completed her thesis in neurosciences at the Marey Institute in Paris, directed by Prof. D. Albe-Fessard. Guided by her curiosity and her constant desire to learn, she changed lab and research domains several times. With the knowledge of other systems and the mastering of other techniques she finally came back to her first and preferred subject of research; the role of the subthalamic nucleus in the basal ganglia system in health and Parkinson's disease.

After many years of lecturing neurobiology to biology and psychology students it became apparent that students were in need of a book to help understand the basic principles of cell electrophysiology. Discussions with Philippe Ascher convinced her that the best way to approach the subject was to explain ionic currents and potential changes in terms of single channels and unitary currents, describing pioneering neurobiological experiments. This first book "Neurobiologie Cellulaire" (written in French with her colleague Danièle Tritsch) appeared in 1990. Its immediate success inspired her to completely revise the book content and publish it in English giving it to a larger audience; Appearing in 1996 the fist edition of "Cellular and Molecular Neuroscience" was born.

Table of Contents

Part I. Neurons: Excitable and Secretory Cells That Establish Synapses 1. Neurons 2. Neuron - Glial Cell Cooperation 3. Ionic Gradients, Membrane Potential and Ionic Currents 4. The Voltage-Gated Channels of Na+ Action Potentials 5. The Voltage-Gated Channels of Ca+2 Action Potentials: Generalization 6. The Chemical Synapses 7. Neurotransmitter Release

Part II. Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction 8. The Ionotropic Nicotinic Acetycholine Receptors 9. The Ionotropic GABAA Receptor 10. The Ionotropic Glutamate Receptors 11. The Metabotropic GABAB Receptors 12. The Metabotropic Glutamate Receptors

Part III. Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials 13. Somato-Dendritic Processing of Postsynaptic Potentials I: Passive Properties of Dendrites 14. Subliminal Voltage-Gated Currents of the Somato-Dendritic Membrane 15. Somato-Dendritic Processing of Postsynaptic Potentials II: Role of Subthreshold Depolarizing Voltage-Gated Currents 16. Somato-Dendritic Processing of Postsynaptic Potentials III: Role of High Voltage-Activated Depolarizing Currents 17. Firing Patterns of Neurons 18. Synaptic Plasticity

Part IV. The Adult Hippocampal Network 19. The Adult Hippocampal Network 20. Maturation of the Hippocampal Network

Editorial Reviews

Reviewer: Manuel Dujovny, MD (Wayne State University School of Medicine)
Description: This fourth edition of a book focusing on the cellular and molecular physiology of nerve cells incorporates 70 percent new or updated material. The previous edition was published in 2008.
Purpose: The purpose is to detail the neuron and the complex, interacting networks of the central nervous system.
Audience: The audience includes neurophysiologists, neurobiologists, and neurologists, as well as graduate students in neurophysiology.
Features: This is a well-organized book with 20 chapters grouped into four sections that cover neurons and neurotransmitter release, ionotropic and metabotropic receptors, somato-dendritic processing and plasticity of postsynaptic potentials, and the hippocampal network. Individual chapters cover topics such as membrane potential, glutamate and GABA receptors, somato-dendritic processing potentials on passive properties of dendrites, and firing patterns of neurons. Interspersed throughout the book, there are 15 appendixes that describe neurobiological techniques and 350 illustrations.
Assessment: This is an excellent work on the cellular and molecular physiology of nerve cells. I would highly recommend it for universities, neuroscience libraries, and physiology departments.

Doody's Review Service

"In its third internationally acclaimed edition, this textbook provides an unrivaled account of the basic foundations of molecular and cellular neurophysiology. For those of us who were inclined to believe that the unprecedented development of neuroscience made neurophysiology disposable, Constance Hammond proves us with conviction and elegance that this is just not the case!"
-Dr. Robert Dantzer, Professor of Psychoneuroimmunology, Integrative Immunology and Behavior Program University of Illinois at Urbana-Champaign

"...a very fluid and self consistent read which should be of interest to neophytes and advanced students alike."
-Jean-Marc Fellous, Professor Psychology, Neuroscience, Cognitive Sciences, and Applied Mathematics, University of Arizona, Tucson

"A particularly strong feature of the book is that most of the exposition is driven by data from original experiments, supplying many figures that offer a ready-made basis for lectures (figures are available on the instructor's website)."
Jim Belanger, Department of Biology, West Virginia University

"More than any similar volume that I have come across in recent years, this one has the potential of luring students of neuroscience and even students from other fields to build a career in neurophysiology."
György Buzsáki, M.D., Ph.D., Board of Governors Professor, Center for Molecular and Behavioral Neuroscience, Rutgers University

"...this book is a very precious and unique tool, ideal for students with a strong interest in neuroscience."
--Jean-Francois Perrier, Institute of Neuroscience and Pharmacology, University of Copenhagen, Denmark

"This is an outstanding book that I will definitely recommend to my students."
--Peter Somogyi, Oxford University, United Kingdom

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