Circular Dichroism and the Conformational Analysis of Biomolecules / Edition 1

by G.D. Fasman

Overview

''Excellent and very timely....It will undoubtedly become a standard reference for the application of circular dichroism (CD) to biomolecules.'' —- Quarterly Review of Biology, March 1997 ''[T]estament to the book's utility is the fact that during the course of my review I had to 'rescue' it from the desks of graduate students on an almost daily basis. In summary, this is a great book.'' —- American Scientist ''Well documented chapters provide a very good insight into the problems surrounding the conformation of biomacromolecules...An indispensible source of information.'' —- Nahrung, 42(2), 1998 Renowned experts present the first state-of-the-art description of circular dichroism spectroscopy (CD). Chapters present in-depth discussions of the history of the field, the theory of CD for application to globular proteins, membrane proteins, peptides, nucleic acids and their interactions, carbohydrates, and instrumentation. Discussions also feature new techniques using synchrotron radiation, vibrational Raman optical activity, and vibrational CD. More than 250 illustrations supplement the text.

Product Details

ISBN-13:	9780306451423
Publisher:	Springer US
Publication date:	04/30/1996
Series:	The Language of Science Series
Edition description:	1996
Pages:	738
Product dimensions:	7.01(w) x 10.00(h) x 0.06(d)

Table of Contents

1. Remembrance of Things Past: A Career in Chiroptical Research.- 2. Theory of Circular Dichroism of Proteins.- 3. Determination of Protein Secondary Structure.- 4. Aromatic and Cystine Side-Chain Circular Dichroism in Proteins.- 5. Stopped-Flow Circular Dichroism.- 6. Circular Dichroism of Collagen and Related Polypeptides.- 7. CD Spectroscopy and the Helix-Coil Transition in Peptides and Polypeptides.- 8. The— Sheet— Coil Transition of Polypeptides, as Determined by Circular Dichroism.- 9. Turns.- 10. Differentiation between Transmembrane Helices and Peripheral Helices by the Deconvolution of Circular Dichroism Spectra of Membrane Proteins.- 11. Theories of Circular Dichroism for Nucleic Acids.- 12. Determination of the Conformation of Nucleic Acids by Electronic CD.- 13. Circular Dichroism of Protein-Nucleic Acid Interactions.- 14. Carbohydrates.- 15. Chaperones.- 16. Vibrational Circular Dichroism: Applications to Conformational Analysis of Biomolecules.- 17. Circular Dichroism Using Synchrotron Radiation: From Ultraviolet to X Rays.- 18. Circular Dichroism Instrumentation.- 19. Vibrational Raman Optical Activity of Biomolecules.

Editorial Reviews

A collection of 19 papers written by 24 eminent chemists considering research and theory on aspects of circular dichroism and the conformational analysis of biomolecules. The discussions examine theory as it applies to the protein secondary structure, aromatic and cystine side-chains, stopped-flow, CD spectroscopy and the helix-coil transition in peptides and polypeptides, turns, nucleic acids, carboydrates, chaperones, instrumentation, and the vibrational Raman optical activity in biomolecules. Includes illustrations, graphs, tables. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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