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Click Chemistry for Biotechnology and Materials Science / Edition 1

Click Chemistry for Biotechnology and Materials Science / Edition 1

by Joerg Lahann


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Product Details

ISBN-13: 9780470699706
Publisher: Wiley
Publication date: 12/21/2009
Pages: 432
Product dimensions: 6.80(w) x 9.90(h) x 1.00(d)

About the Author

Joerg Lahann is Dow Corning Assistant Professor in the Chemical Engineering Department at the University of Michigan (USA). He was educated at the University of Saarland (Germany) and obtained his PhD at RWTH Aachen (Germany) in Macromolecular Chemistry. From 1999 to 2001, Joerg Lahann was a postdoctoral associate in the Chemical Engineering Department of Massachusetts Institute of Technology (USA) and he then spent one year at Harvard University and Massachusetts Institute of Technology (HMST). He joined the Chemical Engineering Department at the University of Michigan in 2003. Professor Lahann has received a number of honors and awards including Technology Review TR100 Young Innovator Award, NSF CAREER Award, the Justus-Liebig Fellowship of the Fonds of the German Industry, Sigma XI - Full Membership, German Science Foundation Postdoctoral Grant, Borchers Prize of the RWTH Aachen (given to graduate students for an outstanding performance), and the Young Student Achievement Award of the Fonds of the German Industry. His research interests are broadly related to surface engineering as well as biomedical engineering and nanotechnology.

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Table of Contents


List of Contributors.


1 Click Chemistry: A Universal Ligation Strategy forBiotechnology and Materials Science (Joerg Lahann).

1.1 Introduction.

1.2 Selected Examples of Click Reactions in Materials Scienceand Biotechnology.

1.3 Potential Limitations of Click Chemistry.

1.4 Conclusions.


2 Common Synthons for Click Chemistry in Biotechnology(Christine Schilling, Nicole Jung and StefanBräse).

2.1 Introduction – Click Chemistry.

2.2 Peptides and Derivatives.

2.3 Peptoids.

2.4 Peptidic Dendrimers.

2.5 Oligonucleotides.

2.6 Carbohydrates.

2.7 Conclusion.


3 Copper-free Click Chemistry (Jeremy M. Baskin andCarolyn R. Bertozzi).

3.1 Introduction.

3.2 Bio-orthogonal Ligations.

3.3 Applications of Copper-free Click Chemistries.

3.4 Summary and Outlook.


4 Protein and Peptide Conjugation to Polymers and SurfacesUsing Oxime Chemistry (Heather D. Maynard, Rebecca M. Broyerand Christopher M. Kolodziej).

4.1 Introduction.

4.2 Protein/Peptide–Polymer Conjugates.

4.3 Immobilization of Proteins and Peptides on Surfaces.

4.4 Conclusions.


5 The Role of Click Chemistry in Polymer Synthesis(Jean-Francois Lutz and Brent S. Sumerlin).

5.1 Introduction.

5.2 Polymerization via CuAAC.

5.3 Post-polymerization Modification via Click Chemistry.

5.4 Polymer–Biomacromolecule Conjugation.

5.5 Functional Nanomaterials.

5.6 Summary and Outlook.


6 Blocks, Stars and Combs: Complex MacromolecularArchitecture Polymers via Click Chemistry (SebastianSinnwell, Andrew J. Inglis, Martina H. Stenzel and ChristopherBarner-Kowollik).

6.1 Introduction.

6.2 Block Copolymers.

6.3 Star Polymers.

6.4 Graft Copolymers.

6.5 Concluding Remarks.


7 Click Chemistry on Supramolecular Materials(Wolfgang H. Binder and Robert Sachsenhofer).

7.1 Introduction.

7.2 Click Reactions on Rotaxanes, Cyclodextrines andMacrocycles.

7.3 Click Reactions on DNA.

7.4 Click Reactions on Supramolecular Polymers.

7.5 Click Reactions on Membranes.

7.6 Click Reactions on Dendrimers.

7.7 Click Reactions on Gels and Networks.

7.8 Click Reactions on Self-assembled Monolayers.


8 Dendrimer Synthesis and Functionalization by ClickChemistry for Biomedical Applications (Daniel Q. McNerny,Douglas G. Mullen, Istvan J. Majoros, Mark M. Banaszak Holl andJames R. Baker Jr).

8.1 Introduction.

8.2 Dendrimer Synthesis.

8.3 Dendrimer Functionalization.

8.4 Conclusions and Future Directions.


9 Reversible Diels–Alder Cycloaddition for the Designof Multifunctional Network Polymers (Amy M. Peterson andGiuseppe R. Palmese).

9.1 Introduction.

9.2 Design of Polymer Networks.

9.3 Application of Diels–Alder Linkages to PolymerSystems.

9.4 Conclusions.


10 Click Chemistry in the Preparation of Biohybrid Materials(Heather J. Kitto, Jan Lauko, Floris P. J. T. Rutjes andAlan E. Rowan).

10.1 Introduction.

10.2 Polymer-containing Biohybrid Materials.

10.3 Biohybrid Structures based on Protein Conjugates.

10.4 Biohybrid Amphiphiles.

10.5 Glycoconjugates.

10.6 Conclusions.


11 Functional Nanomaterials using the Cu-catalyzed HuisgenCycloaddition Reaction (Sander S. van Berkel, Arnold W.G.Nijhuis, Dennis W.P.M. Löwik and Jan C.M. van Hest).

11.1 Introduction.

11.2 Inorganic Nanoparticles.

11.3 Carbon-based Nanomaterials.

11.4 Self-assembled Organic Structures.

11.5 Virus Particles.

11.6 Conclusions.


12 Copper-catalyzed ‘Click’ Chemistry for SurfaceEngineering (Himabindu Nandivada and Joerg Lahann).

12.1 Introduction.

12.2 Synthesis of Alkyne or Azide-functionalized Surfaces.

12.3 Spatially Controlled Click Chemistry.

12.4 Copper-catalyzed Click Chemistry for Bioimmobilization.

12.5 Summary.


13 Click Chemistry in Protein Engineering, Design, Detectionand Profiling (Daniela C. Dieterich and A. JamesLink).

13.1 Introduction.

13.2 Posttranslational Functionalization of Proteins with Azidesand Alkynes.

13.3 Cotranslational Functionalization of Proteins with Azidesand Alkynes.

13.4 BONCAT: Identification of Newly Synthesized Proteins viaNoncanonical Amino Acid Tagging.

13.5 Conclusions and Future Prospects.


14 Fluorogenic Copper(I)-catalyzed Azide–AlkyneCycloaddition Reactions Reactions and their Applications inBioconjugation (Céline Le Droumaguet and QianWang).

14.1 Click Reaction for Bioconjugation Applications.

14.2 Significance of Fluorogenic Reactions inBioconjugation.

14.3 CuAAC-based Fluorogenic Reaction.

14.4 Applications of CuAAC in Bioconjugation.

14.5 Conclusions.


15 Synthesis and Functionalization of Biomolecules via ClickChemistry (Christine Schilling, Nicole Jung and StefanBräse).

15.1 Introduction.

15.2 Labeling of Macromolecular Biomolecules.

15.3 Syntheses of Natural Products and Derivatives.

15.4 Enzymes and Click Chemistry.

15.5 Synthesis of Glycosylated Molecular Architectures.

15.6 Synthesis of Nitrogen-rich Compounds: Polyazides andTriazoles.

15.7 Conclusions.


16 Unprecedented Electro-optic Properties in Polymers andDendrimers Enabled by Click Chemistry Based on theDiels–Alder Reactions (Jingdong Luo, Tae-Dong Kim andAlex K.-Y. Jen).

16.1 Introduction.

16.2 Diels–Alder Click Chemistry for Highly EfficientSide-chain E-O Polymers.

16.3 Diels–Alder Click Chemistry for Crosslinkable E-OPolymers Containing Binary NLO Chromophores.

16.4 Diels–Alder Click Chemistry for NLO Dendrimers.

16.5 Conclusions.



What People are Saying About This

From the Publisher

"This book is a high-quality reference for people working in the field or for people interested in using click chemistry in biotechnology and/or materials science." (Angewandte Chemie, 2010)

"This book should remain an essential reference source for many years." (Chemistry World, April 2010)

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