Drug Metabolism and Transport: Molecular Methods and Mechanisms / Edition 1

by Lawrence H. Lash

Overview

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cyhrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Product Details

ISBN-13:	9781617374944
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	Methods in Pharmacology and Toxicology
Edition description:	Softcover reprint of hardcover 1st ed. 2005
Pages:	388
Product dimensions:	5.98(w) x 9.02(h) x 0.35(d)

Table of Contents

Renal Cyhrome P450s and Flavin-Containing Monooxygenases.- Experimental Approaches for the Study of Cyhrome P450 Gene Regulation.- Insulin and Growth Factor Signaling.- Catalytic Function and Expression of Glutathione Transferase Zeta.- Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases.- Transcriptional Regulation of UDP-Glucuronosyltransferases.- Phenotypic and Genotypic Characterization of N-Acetylation.- Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen.- Modulation of Drug Metabolism and Antiviral Therapies.- Modulation of Thiols and Other Low-Molecular-Weight Cofactors.- Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics.- Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier.- Glutathione Transport in the Kidneys.- Human Cytosolic Sulfotransferases.

Editorial Reviews

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society

From the Publisher