Dubois' Lupus Erythematosus and Related Syndromes - E-Book

by FAAP Wallace MD, Bevra Hahn MD

Overview

For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. - Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. - Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. - Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). - Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. - Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

Product Details

ISBN-13:	9780323550642
Publisher:	Elsevier Science
Publication date:	08/16/2018
Sold by:	Barnes & Noble
Format:	eBook
Pages:	752
File size:	30 MB
Note:	This product may take a few minutes to download.

About the Author

Daniel J Wallace MD, FACP, MACR is a board-certified internist and rheumatologist. A Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA, he is the Associate Director of the Rheumatology Fellowship Program at Cedars-Sinai Medical Center, where he also serves on the Board of Governors. Dr. Wallace has authored nearly 450 peer reviewed manuscripts, 30 book chapters, eight textbooks (on lupus, osteoarthritis, Sjogren's syndrome and fibromyalgia) and his practice includes caring for 2,000 lupus patients, the largest lupus cohort in the United States. Dr Wallace is co-chair of the Lupus Industry Council of the Lupus Research Alliance, past chair of the Lupus Foundation of America, and has served on the Board of Directors of the United Scleroderma Foundation and the Medical Advisory Board of the Sjogren's Syndrome Foundation. He has been Chief of Rheumatology at the City of Hope and Cedars-Sinai Medical Center, and chairman of the Research and Education Foundation of the American College of Rheumatology.Dr. Hahn received her MD from the Johns Hopkins University School of Medicine, where she later trained in Rheumatology. She trained in internal medicine at Washington University in St. Louis. Dr. Hahn heads research groups that do basic studies in the immune abnormalities that cause systemic lupus erythematosus (SLE) and is developing interventions that help restore the immune response to normal. She also heads a group that studies clinical problems in patients with SLE, including accelerated atherosclerosis and potential new therapies (clinical trials). In addition, Dr. Hahn provides clinical consultations for patients with rheumatic diseases, particularly SLE. She also teaches Rheumatology and heads the administration of the Division of Rheumatology, which has 25 full-time faculty, 8 fellows and several undergraduate students, medical students, PhD students, postdoctoral trainees, and an administrative staff.
Daniel J Wallace MD, FACP, MACR is a board-certified internist and rheumatologist. A Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA, he is the Associate Director of the Rheumatology Fellowship Program at Cedars-Sinai Medical Center, where he also serves on the Board of Governors. Dr. Wallace has authored nearly 450 peer reviewed manuscripts, 30 book chapters, eight textbooks (on lupus, osteoarthritis, Sjogren’s syndrome and fibromyalgia) and his practice includes caring for 2,000 lupus patients, the largest lupus cohort in the United States. Dr Wallace is co-chair of the Lupus Industry Council of the Lupus Research Alliance, past chair of the Lupus Foundation of America, and has served on the Board of Directors of the United Scleroderma Foundation and the Medical Advisory Board of the Sjogren’s Syndrome Foundation. He has been Chief of Rheumatology at the City of Hope and Cedars-Sinai Medical Center, and chairman of the Research and Education Foundation of the American College of Rheumatology.

Table of Contents

Preface, vii List of Contributors, viii SECTION 1 What Is Lupus? 1 History of Lupus, 1 2 Definition and Classification of Lupus and Lupus-Related Disorders, 15 3 The Epidemiology of Lupus, 23 SECTION 2 Pathogenesis 4 Overview of Lupus Pathogenesis, 44 5 Genetics of Human SLE, 54 6 Epigenetics of Lupus, 69 7 The Environment and the Host, 86 8 The Innate Immune System in SLE, 93 9 B Cells and Generation of Antibodies, 101 10 T Cells, 116 11 Adaptive and Innate Immunoregulatory Cells, 125 12 Cytokines in Lupus, 137 13 Immunometabolism, 153 14 Animal Models in Lupus, 164 SECTION 3 Mechanisms of Tissue Injury 15 Abnormalities in Immune Complex Clearance and Apoptotic Cell Clearance, 216 16 The Role of Complement in SLE, 224 17 Apoptosis and Inflammatory Forms of Cell Death, 237 18 Tissue Damage in Lupus: Free Radicals and Fibrosis, 248 19 Pathogenesis of Fibrosis—The Lung as a Model, 261 20 Pathogenesis of Lupus Nephritis, 269 21 Pathogenesis of Accelerated Atherosclerosis and Vascular Injury in Systemic Lupus Erythematosus, 294 22 Pathogenesis of Cutaneous Lupus, 305 23 Pathogenesis of Neuropsychiatric Lupus, 317 24 Pathogenesis of Antiphospholipid Antibody Syndrome, 324 25 Pathogenesis of Sjögren's, 338 SECTION 4 Autoantibodies 26 Structure and Derivation of Autoantibodies, 340 27 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes, 355 28 Antibodies Against ENA (Sm, RNP, SSA, SSB), 366 29 Antibodies Against C1q, 372 30 Antilipoprotein and Antiendothelial Cell Antibodies, 375 31 Drug-Induced Lupus Erythematosus, 377 SECTION 5 Clinical Aspects of Lupus Erythematosus 32 Overview and Clinical Presentation, 389 33 Skin Disease in Cutaneous Lupus Erythematosus, 395 34 The Musculoskeletal System and Bone Metabolism, 407 35 Lupus and the Cardiopulmonary System, 418 36 Lupus and the Nervous System: Clinical Aspects, Psychopathology, and Imaging, 434 37 Gastrointestinal and Hepatic Systems, 457 38 Hematologic and Lymphoid Abnormalities in SLE, 473 39 Neonatal Lupus: Pathogenesis and Clinical Approaches, 486 40 Pregnancy and Autoimmune Disease, Reproductive and Hormonal Issues, 499 41 Systemic Lupus Erythematosus in Childhood and Adolescence, 520 42 Clinical Aspects of Antiphospholipid Syndrome, 532 43 Lupus and Infections, 543 44 Ocular, Aural, and Oral Manifestations of Lupus, 556 45 Clinical Aspects of Sjögren's, 566 SECTION 6 Assessment of Lupus 46 Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in Systemic Lupus Erythematosus, 579 47 Differential Diagnosis and Disease Associations, 598 48 Incomplete Lupus, Undifferentiated Connective Tissue Disease, and Mixed Connective Tissue Disease, 606 49 Clinical Markers, Metrics, Indices, and Clinical Trials, 614 50 Lupus Biomarkers, 631 SECTION 7 Management of Lupus 51 Principles of Therapy, Local Measures, and NSAIDs, 640 52 Antimalarial Medications, 650 53 Systemic Glucocorticoid Therapy for SLE, 661 54 Immunosuppressive Drug Therapy, 673 55 Complementary and Alternative Medications, Specialized and Niche Therapies, 689 56 Adjunctive Treatments and Preventive Measures, 702 57 Targeted Therapies in SLE, 710 58 Management of Cutaneous Lupus Erythematosus, 719 59 Epidemiology and Management of Lupus Nephritis, 727 60 Management of Sjögren's, 745 SECTION 8 Outcomes 61 Socioeconomic and Disability Aspects, 759 62 Prognosis and Mortality of SLE, 770 Index, 782

What People are Saying About This

From the Publisher

The definitive text for more than 50 years … now updated for the needs of today’s clinician

Editorial Reviews

"This book is a comprehensive and up-to-date review of Lupus Erythematosus and related syndromes written by over 100 experts in the field. The previous edition was published in 2018." ©Doody’s Review Service, 2024, Massoud Mahmoudi, DO, PhD (University of California San Francisco)

From the Publisher