Exposed Science: Genes, the Environment, and the Politics of Population Health

Exposed Science: Genes, the Environment, and the Politics of Population Health

by Sara Shostak

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We rely on environmental health scientists to document the presence of chemicals where we live, work, and play and to provide an empirical basis for public policy. In the last decades of the 20th century, environmental health scientists began to shift their focus deep within the human body, and to the molecular level, in order to investigate gene-environment interactions. In Exposed Science, Sara Shostak analyzes the rise of gene-environment interaction in the environmental health sciences and examines its consequences for how we understand and seek to protect population health. Drawing on in-depth interviews and ethnographic observation, Shostak demonstrates that what we know – and what we don’t know – about the vulnerabilities of our bodies to environmental hazards is profoundly shaped by environmental health scientists’ efforts to address the structural vulnerabilities of their field. She then takes up the political effects of this research, both from the perspective of those who seek to establish genomic technologies as a new basis for environmental regulation, and from the perspective of environmental justice activists, who are concerned that that their efforts to redress the social, political, and economical inequalities that put people at risk of environmental exposure will be undermined by molecular explanations of environmental health and illness. Exposed Science thus offers critically important new ways of understanding and engaging with the emergence of gene-environment interaction as a focal concern of environmental health science, policy-making, and activism.

Product Details

ISBN-13: 9780520955240
Publisher: University of California Press
Publication date: 02/15/2013
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 312
File size: 2 MB

About the Author

Sara Shostak is Assistant Professor of Sociology at Brandeis University.

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Exposed Science

Genes, the Environment, and the Politics of Population Health

By Sara Shostak


Copyright © 2013 The Regents of the University of California
All rights reserved.
ISBN: 978-0-520-95524-0


"Toxicology Is a Political Science"

In September 2007, an array of prominent environmental health scientists and activists was called to testify before Congress. Seated before the Domestic Policy Subcommittee of the House of Representative's Committee on Oversight and Government Reform were Samuel Wilson, then acting Director of the National Institute of Environmental Health Sciences (NIEHS), George Lucier, former Director of the National Toxicology Program (NTP), Lynn Goldman, a professor of environmental health science at the Johns Hopkins University School of Public Health, Peggy Shepard, the Executive Director of the EJ group West Harlem Environmental Action (WEACT), and Stefani Hines, a member of the National Advisory Environmental Health Sciences Council (NAEHSC). The question before them was no less than whether the NIEHS was fulfilling its public health mission. Specifically under scrutiny was "a new set of research priorities" at the NIEHS, which had been implemented by its recently departed Director, David Schwartz. The chairman of the subcommittee opened the hearing with two questions: "At what cost has come Dr. Schwartz's new direction for the NIEHS?" and "Should the new NIEHS research directions and priorities ... continue?" (US GPO 2007: 2).

Particularly at stake in the hearing was the boundary between biomedicine, with its focus on curing disease in individuals, and public health, with its focus on population-based disease prevention. In fact, the focal concern of the subcommittee was whether the NIEHS was becoming too biomedical in its orientation and thereby failing to meet its public health mandate. In his opening comments, the subcommittee chair expressed concern about the shifting of "significant resources toward research that was clinical in nature and which focused on discoveries that would contribute to treating or curing disease once a patient was already afflicted" (US GPO 2007: 1). In advance of this hearing, the staff of the subcommittee had "performed its own analysis of the NIEHS' new research direction and priorities" and reached the conclusion that the public health focus of the NIEHS was being replaced with "programs of a clinical nature" (US GPO 2007: 2).

During the hearing, the speakers used a series of contrasts to distinguish the NIEHS and the NTP in particular, as well as the environmental health sciences more broadly, from the clinical focus of most biomedical research. To begin, in contrast to research that focuses on clinical treatments, the environmental health sciences focus on disease prevention: "NIEHS is the only institute with a primary mission of public health, rather than clinical medicine ..." (US GPO 2007: 69). In contrast to research that is oriented to the development of new drugs or medical treatments, the environmental health sciences inform public policy, "mak[ing] major impacts on human health through research translation to public policy, not to the bedside" (US GPO 2007: 69). In contrast to research that is individually oriented, the environmental health sciences contribute to protecting the health of the population, serving as "the source of key information regarding the health impacts of pollution ... used daily in setting protective federal, state, and local policies, in arguing for the protection of children, the elderly, and our communities" (US GPO 2007: 77). In contrast to research that is defined by a specific disease or organ, the environmental health sciences investigate environmental exposures which affect multiple bodily systems and are associated with myriad diseases: "Every disease has an environmental component, thus NIEHS's responsibilities encompass all human diseases, rather than following the more common model of focus on a specific disease or organ system" (US GPO 2007: 26). In contrast to research that can be accomplished in laboratory and clinical settings alone, the environmental health sciences engage with affected communities and must consider their concerns: "We must be productively linked to our constituents ... to fulfill the promise of our mission" (US GPO 2007: 29). Again, the boundary between biomedicine and public health was a focal concern, as speakers emphasized that "prevention and environmental intervention represent the most effective and efficient ways to improve human health, and this core principle should not be lost in favor of technical, individually oriented medical solutions" (US GPO 2007: 72).

Given the preventive and public health focus of the scientists testifying before the panel, their comments regarding molecular genetics and genomics were quite striking. Genetics has most often been associated with exactly the technical, clinical, individually oriented biomedical approaches that scientists described as what the environmental health sciences are not. However, in their testimonies before Congress, these speakers highlighted molecular genetic approaches as a promising solution to the ongoing and seemingly intractable problems confronted by scientists who seek to explicate relationships between environments, human bodies, and health and illness. Repeatedly, in their description of the agenda of the NIEHS, they asserted powerfully the importance of "new opportunities in science" (US GPO 2007: 23), particularly in molecular genetics and genomics, for environmental health research. Goldman described the NIEHS as "positioned to harness the next generation of scientific advances, such as in molecular biology and genetics, in the service of advancing environmental health sciences" (US GPO 2007: 70). Wilson explicitly connected molecular genetics research to the public health mission of the NIEHS, stating, "Our understanding of how the environment operates at the molecular level can also provide insights on interventions and early markers for disease ..." and emphasizing the importance of evaluating how "emerging technologies can be used to enhance public health prevention strategies" (US GPO 2007: 21, 28, emphasis added). Lucier highlighted the importance of "technological innovations and molecular biology" for the NTP. Likewise, Hines emphasized the importance of approaches that would "bring environmental health research out of the sidelines where it consists only of testing chemicals for toxicity into a more mainstream role where research would investigate how environmental agents contribute to specific diseases that impact public health on a large scale" (US GPO 2007: 79–80).

What can we learn from this hearing? First, the major institutions of environmental health research must answer to Congress for their actions. They are accountable, particularly, for their contributions to public health policy. Their funding depends on meeting their missions and mandates, as understood by politicians in Congress. Second, and related, the environmental health sciences have defined themselves as being part of public health and in contrast to biomedicine. Indeed, the NIEHS consciously seeks to establish an identity as "the prevention Institute." At the center of this distinction is the difference between protecting health and preventing illness using population-level interventions, such as environmental regulation, versus treating disease using individual clinical interventions, such as pharmaceuticals. Third, given their focus on population-level interventions, there has been a push within the environmental health sciences to engage with affected communities and to work collaboratively to address environmental concerns. Fourth, by 2007, leading environmental health scientists, standing in front of the legislative body that authorizes their funding, were making strong claims about the importance of molecular genetic techniques to their public health mission.

Explaining why and how molecular genetics became positioned as a critical component of environmental health research, regulation, and policy making is the central concern of this book. Toward that end, my goal in this chapter is to provide a map of the institutional actors in the U.S. environmental health arena and to introduce their relationships and key struggles. In so doing, I draw both on the comments made before Congress in 2007 and a broader sociological analysis.


Understanding Environmental Exposures

At the center of the environmental health arena are questions and controversies about whether specific environmental exposure poses a risk to human health and, if so, under what conditions (e.g., at what dose, via which routes of exposure, for whom, etc.) and how such risks are best controlled. Environmental health scientists and scientific institutions play a central role in this arena. In most instances, knowledge of environmental hazards is contingent upon "the 'sensory organs of science'—theories, experiments, measuring instruments—in order to become visible or interpretable as hazards at all" (Beck 1992: 27, emphasis in original). Chemicals in the settings where we live, work, and play, in what we eat, and in the products we use to care for our bodies, clean our homes, tend to our yards, and so on are often neither visible nor perceptible to the persons being exposed to them (Altman et al. 2008). Additionally, many toxic substances have a lengthy latency period before the effects of exposure emerge, and others may affect not the person exposed but her or his children (Schettler et al. 2000; Steingraber 2003). Consequently, people are exposed without their knowledge to combinations of chemicals as they move through their homes, workplaces, and communities. Moreover, although members of the public may fear, perceive, and even document evidence of suspected environmental hazards (Brown & Mikkelson 1994), the legitimate recognition of a risk requires the tools and practices of science: "So long as risks are not recognized scientifically, they do not exist—at least not legally, medically, technologically, or socially—and they are thus not prevented, treated or compensated for. No amount of collective moaning can change this, only science" (Beck 1992: 71).

This "scientization" has been challenged by environmental health activists, who argue that individuals and communities have important "lay knowledge" about environmental hazards (Corburn 2005) and should not be excluded from policy debates (Brown 2007: 19). There is some evidence that activists' challenges to the technical practices of environmental health science have created opportunities for new forms of knowledge production (Ottinger & Cohen 2011). Nonetheless, environmental health science remains the authoritative idiom for making claims about the effects of environmental exposures on human health. As we will see, science is therefore also the idiom in and through which controversies about the effects of environmental exposures and regulatory strategies take place.

Explaining the relationships among bodies, environmental exposures, and human health and illness is the primary focus of the sciences of environmental epidemiology and toxicology. Epidemiology is the study of "disease occurrence in human populations and the factors that influence these patterns" (Lillienfield & Stolley 1994: 3). Epidemiologists use a variety of study designs, all of which rely heavily on statistical techniques, for establishing and quantifying the relationships between exposure to risk factors and disease outcomes in human populations. Environmental epidemiologists focus particularly on the effects of exposures in the ambient environment (e.g., air, water, soil). Toxicology is "the study of the adverse effects of xenobiotics" (Gallo 1996: 3) and includes both the study of absorption, distribution, excretion, and biotransformation of such agents and the analysis of basic toxicological processes within specific organ systems. Although much toxicology is ultimately concerned with human health and illness, toxicologists rely heavily on animal models, in vitro bioassays, and laboratory research (Sellers 1997; NTP 2002). Epidemiology and toxicology are the "core sciences" of public health in the United States (Omenn 2000). Institutionally, academic departments of epidemiology and toxicology are located in schools of public health, where their faculties often staff multidisciplinary environmental health research centers.

The location of environmental health science within the context of public health has had profound implications for the work of environmental health scientists, shaping patterns of funding, defining markets for their research, and determining opportunity structures for employment. In contrast to much research in the contemporary life sciences, which is oriented to biomedical interventions such as new pharmaceuticals or devices, the primary consumers of environmental health research include risk assessors, regulators, and policy makers; there is no promise of a lucrative "magic bullet," or cure, to environmental exposures or their consequences. This dynamic was highlighted at the Congressional hearing, when the subcommittee chair noted "... a significant failure of the market system: there is little profit in prevention when compared to treatment" (US GPO 2007: 7). As such, there are few incentives for private sector investment in environmental health research, aside from that sponsored by companies seeking EPA or FDA approval for their products. As one environmental health scientist commented," ... in contrast to a lot of other biomedical research where there are opportunities to make money, to patent a new drug, to patent a new protein, [in the environmental health sciences] you're constantly fighting an uphill battle with economic forces that would rather preserve the status quo" (Interview S50).

The often adversarial and litigious nature of the regulatory process in the United States also has shaped research institutions, practices, and possibilities in the environmental health sciences. Indeed, environmental health research was institutionalized at the federal level, in part, as a response to dynamics of contention and litigation surrounding risk assessment by the federal regulatory agencies (Jasanoff 1990, 1995). In the late 1960s and early 1970s, the federal government invested in a massive expansion of research capacity designed to bolster risk assessment by generating new and better scientific practices and identifying omissions, mistakes, and biases in extant data, especially those obtained from nongovernmental sources, such as industry (Jasanoff 1990: 41).

The National Institute of Environmental Health Sciences

The mission of the NIEHS is to support research to define the role of environmental agents in the initiation and progression of human disease. The goal is to use knowledge from this research to reduce adverse exposures and, thus, reduce preventable diseases and conditions. Testimony of Samuel Wilson (U.S. GPO 2007: 21)

In 1969, Congress established the NIEHS and mandated it to direct basic research on the effects of environmental factors on human health (RTI 1965; see also Frickel 2004).At the turn of the current century, the NIEHS mission was to "to reduce the burden of human illness and dysfunction from environmental causes." The NIEHS is the only one of the National Institutes of Health (NIH) defined by an independent or etiologic variable—the environment—rather than a disease (e.g., National Cancer Institute, [NCI] National Institute of Neurological Disorders and Stroke [NINDS]), organ or organ system (e.g., National Eye Institute [NEI], National Heart, Lung, and Blood Institute [NHLBI]), or a population group and/or developmental process (e.g., National Institute for Child Health and Human Development [NICHD], National Institute on Aging [NIA]). In the words of a former scientific director of the NIEHS:

the key thing about environmental agents is that they show no disease boundaries, so the same chemical that causes cancer could also cause pulmonary disease, Alzheimer's, etc. So one of the challenges to environmental health sciences is really to be able to look at all of these different diseases. We don't have the luxury of just studying cancer. Obviously we have a big institute that just studies cancer [NCI], but they [NIEHS] have to deal with cancer and neurodegenerative diseases, and pulmonary diseases and kidney diseases (Barrett, Oral History Interview February 2004).


Excerpted from Exposed Science by Sara Shostak. Copyright © 2013 The Regents of the University of California. Excerpted by permission of UNIVERSITY OF CALIFORNIA PRESS.
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Table of Contents



Chapter 1
"Toxicology is a Political Science"
Chapter 2
The Consensus Critique
Chapter 3
Susceptible Bodies
Chapter 4
"Opening the Black Box of the Human Body"
Chapter 5
Making a Molecular Regulatory Science
Chapter 6
The Molecular is Political


Appendix A


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