G Protein-Coupled Receptors: Signaling, Trafficking and Regulation

by Arun K. Shukla (Editor)

Overview

G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation. - Covers the increasingly appreciated cell biology field of G-protein-coupled receptors - Includes both established and new technologies - Contributed by experts in the field - Covers topics such as signaling, trafficking, and regulation

Product Details

ISBN-13:	9780128036129
Publisher:	Elsevier Science & Technology Books
Publication date:	02/26/2016
Series:	Methods in Cell Biology , #132
Sold by:	Barnes & Noble
Format:	eBook
Pages:	502
File size:	18 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.

Table of Contents

Section 1 Trafficking, Localization and Imaging of GPCRs1. Localization and Signaling of GPCRs in Lipid RaftsVan Anthony M. Villar, Santiago G. Cuevas, Xiaoxu Zheng, Pedro A. Jose2. Imaging GPCRs Trafficking and Signaling with Total Internal Reflection Fluorescence Microscopy in Cultured NeuronsFrancheska Delgado-Peraza, Carlos Nogueras-Ortiz,  Agnes M. Acevedo Canabal, Cristina Roman-Vendrell, Guillermo A. Yudowski3. Trafficking of Ciliary G-Protein Coupled ReceptorsJeremy McIntyre, Mellisa M. Hege, Nicolas F. Berbari4. Single Molecule Resolution of G Protein-Coupled Receptor (GPCR) ComplexesKim C Jonas, Ilpo Huhtaniemi, Aylin C Hanyaloglu5. Quantification of the mRNA Expression of G-protein Coupled Receptors in Human Adipose TissueStefan AmistenSection 2 Signaling and Regulation of GPCRs6. Studying the Regulation of Endosomal cAMP Production in GPCR SignalingAlexandre Gidon, Timothy N. Feinstein, Kunhong Xiao, Jean-Pierre Vilardaga7. GPCR-Radioligand Binding AssaysColleen A. Flanagan8. Assessing Smoothened-Mediated Hedgehog Signaling in ZebrafishTeresa Casar Tena, Melanie Philipp9. GPCRs and Actin-Cytoskeleton DynamicsGenaro Vázquez-Victorio, Claudia González-Espinosa, Zyanya P. Espinosa-Riquer, Marina Macías-SilvaSection 3 Cellular Assays for GPCRs10. Olfactory Receptor Signaling Gabriela Antunes, Fabio Marques Simoes de Souza11. Tracking GPCR Biosynthesis and Degradation Using a Non-Radioactive Pulse Chase MethodologyRichard B. Vallee Richard Wargachuk, Dominic Devost, Cynthia Zhou, Terence E. Hébert12. Tango Assay for Ligand Induced GPCR - β-arrestin2 Interaction: Application in Drug DiscoveryShalini Dogra, Chandan Sona, Ajeet Kumar, Prem N Yadav13. Resonance Energy Transfer-Based Approaches to Study GPCRs Mohammed Akli Ayoub14. Quantitative Analysis of G Protein-Coupled Receptor Internalization Using DnaE Intein-Based AssayBin Lu, Linjie Chen, Yaping Zhang, Ying Shi, Naiming Zhou15. Cellular and Subcellular Context Determine Outputs from Signalling BiosensorsDominic Devost, Nicolas Audet, Cynthia Zhou, Hiroyuki Kobayashi, Hélène Bonin, Viktorya Lukashova, Christian Le Gouill, Michel Bouvier, Terence E. HébertSection 4 Structural and Computational Investigation of GPCRs16. Protease-Activated Receptors PARs in Cancer: Novel Biased Signaling and Targets for TherapyBar-Shavit R, Maoz M, Kancharla A, Jaber M, Agranovich D, Grisaru-Granovsky S, Uziely B17. Computational Methods for Studying G Protein-Coupled Receptors (GPCRs)Agnieszka A. Kaczor, Ewelina Rutkowska, Damian Bartuzi, Katarzyna M. Targowska-Duda, Dariusz Matosiuk, Jana Selent18. Comparing Class A GPCRs to Bitter Taste Receptors: Structural Motifs, Ligand Interactions and Agonist-to-Antagonist RatiosAntonella Di Pizio, Anat Levit, Michal Slutzki, Maik Behrens, Rafik Karaman, Masha Y Niv19. What Can Simulations Tell Us About GPCRs: Integrating the ScalesDurba Sengupta, Manali Joshi, Chaitanya A. Athale, Amitabha Chattopadhyay

What People are Saying About This

From the Publisher

This new volume in the Methods in Cell Biology series covers the increasingly appreciated field of G-protein-coupled receptors, and includes chapters authored by respected leaders in the field who cover topics such as signaling, trafficking, and regulation.