Handbook of Biomedical Nonlinear Optical Microscopy

by Barry R. Masters (Editor), Peter So (Editor)

Overview

The Handbook of Biomedical Nonlinear Optical Microscopy provides comprehensive treatment of the theories, techniques, and biomedical applications of nonlinear optics and microscopy for cell biologists, life scientists, biomedical engineers, and clinicians. The chapters are separated into basic and advanced sections, and provide both textual and graphical illustrations of all key concepts. The more basic sections are aimed at life scientists without advanced training in physics and mathematics, and tutorials are provided for the more challenging sections. The first part of the Handbook introduces the historical context of nonlinear microscopy. The second part presents the nonlinear optical theory of two- and multiphoton excited fluorescence (TPE, MPE) spectroscopy, second and third harmonic generation (SHG, THG) spectroscopy, and coherent anti-Stokes Raman spectroscopy (CARS). The third part introduces modern microscopic and spectroscopic instrumentation and techniques that are based on nonlinear optics. The fourth part provides key applications of nonlinear microscopy to the biomedical area: neurobiology, immunology, tumor biology, developmental biology, dermatology, and cellular metabolism. There are also chapters on nonlinear molecular probes, cellular damage, and nanoprocessing.

Product Details

ISBN-13:	9780198036821
Publisher:	Oxford University Press
Publication date:	05/19/2008
Sold by:	Barnes & Noble
Format:	eBook
File size:	15 MB
Note:	This product may take a few minutes to download.

About the Author

Professor Peter T. C. So is a Professor of Mechanical Engineering and Biological Engineering at the Massachusetts Institute of Technology (MIT), Cambridge, MA. He received a B.S. degree in physics and mathematics in 1986 from the Harvey Mudd College and a Ph.D. degree in physics in 1992 from Princeton University. Professor So joined MIT as a faculty member in 1996. Professor So has published over 75 research papers in refereed journals, over 30 refereed conference proceedings, many book chapters, and numerous scientific abstracts. He is also the co-inventor of five patents related to microscopy and instrumentation. Barry R. Masters is a visiting scientist in the Department of Biological Engineering at the Massachusetts Institute of Technology and a visiting scholar in the Department of the History of Science at Harvard University. He was formerly a professor in anatomy at the Uniformed Services University of the Health Sciences. He is a Fellow of the Optical Society of America (OSA), the International Society for Optical Engineering (SPIE), and the American Association for the Advancement of Science (AAAS). Professor Masters has published 81 refereed research papers and 128 book chapters and articles. He is the editor or author of Noninvasive Diagnostic Techniques in Ophthalmology; Medical Optical Tomography: Functional Imaging and Monitoring; Selected Papers on Confocal Microscopy; Selected Papers on Optical Low-Coherence Reflectometry and Tomography; Selected Papers on Multiphoton Excitation Microscopy; Confocal Microscopy and Multiphoton Excitation Microscopy: the Genesis of Live Cell Imaging; and with Peter So, Handbook of Biomedical Nonlinear Optical Microscopy. Professor Masters is a member of the editorial board of Graefe's Archive for Clinical and Experimental Ophthalmology. His research interests include the development of in vivo microscopy of the human eye and skin, biomedical imaging and spectroscopy, and the fractal analysis of branching vascular patterns.

Table of Contents

List of ContributorsForeword, Watt WebbPart I. Historical Development of Nonlinear Optical Spectroscopy and MicroscopyIntroduction to Part I: Historical Development of Nonlinear Optical Microscopy and Spectroscopy, Barry R. MastersChapter 1. The Genesis of Nonlinear Optical Microscopies and Their Impact on Modern Developments, Barry R. Masters and Peter T. C. SoChapter 2. The Scientific Life of Maria Göppert-Mayer, Barry R. MastersChapter 3. The History of Perturbation Theory from Astronomy to Quantum Mechanics, Barry R. MastersChapter 4. English Translations of and Translator's Notes on Maria Göppert-Mayer's Theory of Two-Quantum Processes, Barry R. MastersPart II. Nonlinear Optical SpectroscopyIntroduction to Part II: Nonlinear Optical Spectroscopy, Robert W. Boyd and Barry R. MastersChapter 5. Classical and Quantum Theory of One-Photon and Multiphoton Fluorescence Spectroscopy, Barry R. Masters and Peter T. C. SoChapter 6. Second- and Higher-Order Harmonic Generation, Robert W. BoydChapter 7. Theory of Spontaneous and Coherent Raman Scattering, Eric O. Potma and X. Sunney XiePart III. Nonlinear Optical Instruments for Microscopic Imaging and AnalysisIntroduction to Part III: Nonlinear Optical Instruments for Microscopic Imaging and Analysis: Review and Forecast, Peter T. C. So and Daekeun KimChapter 8. Laser Sources for Non-Linear Microscopy, John GirkinChapter 9. Ultrashort Optical Pulse Delivery for Nonlinear Optical Microscopy, Peter T.C. So and Daekeun KimChapter 10. An Optical Design Primer for Nonlinear Optical Microscopy, Peter T. C. So and Daekeun KimChapter 11. Image Formation in Multiphoton Fluorescence Microscopy, Min GuChapter 12. Signal Detection and Processing in Nonlinear Optical Microscopes, Siavash Yazdanfar and Peter T. C. SoChapter 13. Multiphoton Excitation of Fluorescent Probes, Chris Xu and Warren R. ZipfelChapter 14. Multiphoton-Induced Cell Damage, Karsten KönigChapter 15. Applications of Second-Harmonic Generation Microscopy, Jerome MertzChapter 16. Second-Harmonic Generation Imaging Microscopy of Structural Protein, Paul J. CampagnolaChapter 17. Coherent Anti-Stokes Raman Scattering (CARS) Microscopy: Instrumentation and Applications, Eric O. Potma and X. Sunney XieChapter 18. High-speed Imaging Using Multiphoton Excitation, Ki H. Kim, Karsten Bahlmann, Timothy Ragan, Daekeun Kim, and Peter T. C. SoChapter 19. Nonlinear Multi-Spectral Optical Imaging Microscopy: Concepts, Instrumentation, and Applications, Sebastian Wachsmann-Hogiu and Daniel L. FarkasChapter 20. Multiphoton Polarization Microscopy, Yen Sun, Wen Lo, Jiunn Wen Su, Sung-Jan Lin, Shiou-Hwa Jee, and Chen-Yuan DongChapter 21. Lifetime-Resolved Imaging in Nonlinear Microscopy, Wolfgang Becker and Axel BergmannChapter 22. Förster Resonance Energy Transfer (FRET), Barry R. Masters and Peter T. C. SoChapter 23. Two-Photon Förster Resonance Energy Transfer (FRET) Microscopy, Ye Chen, Horst Wallrabe and Ammasi PeriasamyChapter 24. Diffraction Unlimited Far-Field Fluorescence Microscopy, Andreas Schönle, Jan Keller, Benjamin Harke, and Stefan W. HellChapter 25. Two-Photon Fluorescence Correlation Spectroscopy, Suzette Pabit and Keith BerlandChapter 26. Photobleaching and Recovery with Nonlinear Microscopy, Edward Brown, Ania Majewska, and Rakesh K. JainChapter 27. Femtosecond Laser Nanoprocessing, Karsten KönigPart IV. Biomedical Applications of Nonlinear Optical MicroscopyIntroduction to Part IV: Biomedical Applications of Nonlinear Optical Microscopy, Bruce J. TrombergChapter 28. Pioneering Applications Of Two-Photon Microscopy To Mammalian Neurophysiology: Seven Case Studies, Q.-T. Nguyen, G. O. Clay, N. Nishimura, C. B. Schaffer, L. F. Schroeder, P. S. Tsai, and D. KleinfeldChapter 29. Applications of Non-Linear Intravital Microscopy in Tumor Biology, Rakesh K. Jain, Michael F. Booth, Timothy P. Padera, Lance L. Munn, Dai Fukumura, and Edward BrownChapter 30. Immunology Based on Nonlinear Optical Microscopy, Ian Parker and Michael D. CahalanChapter 31. Multiphoton Imaging in Animal Development, Irina V. Larina and Mary E. DickinsonChapter 32. Nonlinear Microscopy Applied to Dermatology, Barry R. Masters and Peter T. C. SoChapter 33. Cellular Metabolism Monitored by NAD(P)H Imaging with Two-Photon Excitation Microscopy, Barry R. MastersIndex

Editorial Reviews

The Handbook of Biomedical Nonlinear Optical Microscopy will be invaluable for anyone who plans to enter this complex and rapidly developing field and it will be a useful reference for experienced researchers as well."— Journal of Biophotonics

"A guide for the field of nonlinear optical spectroscopy and microscopy has emerged with the publication of a conceptually interesting, information-rich, well-written, comprehensive, current, and eminently practical handbook. It deserves a place on the bookshelf of every researcher considering or conducting biomedical optical studies."—William W. Mantulin, Journal of Biomedical Optics

"Professors Masters and So have done an excellent job organizing the chapters of this book and choosing the scientists, whose contributions are excellent. The first part is a"must" read. The way the book is written, even if the reader wants to focus only on the applications presented, it is possible to understand the application chapters as stand-along papers as they are edited to contain clear, detailed text, with the figures and supporting references one expects from a handbook. I strongly recommend this book to scientists with any scientific background who are involved with nonlinear microscopies." — Dr. Susana A. Sanchez for Microscopy and Microanalysis

From the Publisher