Handbook of High Field Dynamic Nuclear Polarization / Edition 1

by Vladimir K. Michaelis, Robert G. Griffin, Bj rn Corzilius, Shimon Vega

Overview

Addresses Dynamic Nuclear Polarization (DNP) as a technique for sensitivity-enhancement in solid-state NMR spectroscopy

This comprehensive handbook is a compendium of the current state-of-the art of high field Dynamic Nuclear Polarization—from long-proven, early developments, up to today’s hot topics. It covers all the relevant subjects that have made a direct or indirect contribution toward advancing this field, and focuses on topics such as: the theory behind the effects seen within DNP; instrumentation required for carrying out DNP; and specific applications of DNP including protein monitoring, catalysis, nanoparticles, biological and clinical studies. Development and application of techniques that have indirectly contributed to advancing MAS DNP NMR, such as DNP experiments on static solids within microwave resonant structures, and high-field EPR, are also examined.

Handbook of High Field Dynamic Nuclear Polarization is presented in three sections—Theoretical Aspects, DNP Development (instrumentation / radical / sample), and DNP NMR Applications. The first section offers chapters on; solid and cross effect DNP; thermal mixing; Overhauser; and dissolution DNP. The second looks at: microwave technology, gyrotron, and IOE; homebuilt and commercial DNP spectrometers; and glassing vs. solvent-free DNP. The final section provides information on; amyloid, membrane, and nanocrystalline proteins; metals, and surface enhanced DNP; pharmaceuticals; nanoparticles; and much more. 

• Covers one of the biggest developing fields in magnetic resonance
• Relevant to students, academics, and industry within the physical, materials, medical, and biochemical sciences
• An excellent starting point and point-of-reference for researchers in the field
• Edited by a widely respected team with contributions from key researchers in the NMR community
• Part of the eMagRes Handbook Series

Handbook of High Field Dynamic Nuclear Polarization is an ideal reference for all researchers and graduate students involved in this complex, interdisciplinary field.

About eMagRes Handbooks

eMagRes publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.

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Product Details

ISBN-13:	9781119441649
Publisher:	Wiley
Publication date:	02/03/2020
Series:	eMagRes Books
Pages:	472
Product dimensions:	7.60(w) x 9.80(h) x 1.10(d)

About the Author

Editors

Vladimir K. Michaelis is Assistant Professor in the Department of Chemistry at the University of Alberta.

Robert G. Griffin is Professor of Chemistry and Director of the Francis Bitter Magnet Laboratory at the Massachusetts Institute of Technology.

Björn Corzilius is Professor of Physical Chemistry in the Institute of Chemistry at the University of Rostock.

Shimon Vega is Professor in the Department of Chemical Physics at the Weizmann Institute of Science, Israel.

Table of Contents

Contributors xi

Series Preface xvii

Preface xix

Acknowledgments xxi

Part A: Concepts, Theory, & Instrumentation 1

1 The Discovery and Demonstration of Dynamic Nuclear Polarization–A Personal and Historical Account 3
Charles P. Slichter

2 DNP Mechanisms 15
Krishnendu Kundu, Frédéric Mentink-Vigier, Akiva Feintuch, and Shimon Vega

3 Pulsed Dynamic Nuclear Polarization 71
Kong Ooi Tan, Sudheer Jawla, Richard J. Temkin, and Robert G. Griffin

4 MAS-DNP Enhancements: Hyperpolarization, Depolarization, and Absolute Sensitivity 87
Sabine Hediger, Daniel Lee, Frédéric Mentink-Vigier, and Gaël De Paëpe

5 Polarizing Agents: Evolution and Outlook in Free Radical Development for DNP 103
Gilles Casano, Hakim Karoui, and Olivier Ouari

6 Paramagnetic Metal Ions for Dynamic Nuclear Polarization 121
Björn Corzilius

7 Instrumentation for High-field Dynamic Nuclear Polarization NMR Spectroscopy 143
Guy M. Bernard and Vladimir K. Michaelis

8 Millimeter-wave Sources for DNP-NMR 155
Monica Blank and Kevin L. Felch

9 Cryogenic Platforms and Optimized DNP Sensitivity 169
Yoh Matsuki and Toshimichi Fujiwara

10 Versatile Dynamic Nuclear Polarization Hardware with Integrated Electron Paramagnetic Resonance Capabilities 189
Alisa Leavesley, Ilia Kaminker, and Songi Han

11 Dissolution Dynamic Nuclear Polarization Methodology and Instrumentation 219
Dennis Kurzbach and Sami Jannin

12 Introduction to Dissolution DNP: Overview, Instrumentation, and Human Applications 239
Jan H. Ardenkjaer-Larsen

13 Liquid-state Overhauser DNP at High Magnetic Fields 261
Vasyl P. Denysenkov and Thomas F. Prisner

14 Overhauser DNP in Liquids on 13C Nuclei 279
Marina Bennati and Tomas Orlando

Part B: Applications 289

15 DNP and Cellular Solid-state NMR 291
Alessandra Lucini Paioni, Marie A.M. Renault, and Marc Baldus

16 Cryo-trapped Intermediates of Retinal Proteins Studied by DNP-enhanced MAS NMR Spectroscopy 305
Johanna Becker-Baldus and Clemens Glaubitz

17 DNP Solid-state NMR of Biological Membranes 323
Burkhard Bechinger

18 DNP in Materials Science: Touching the Surface 337
Pierrick Berruyer, Lyndon Emsley, and Anne Lesage

19 Growing Signals from the Noise: Challenging Nuclei in Materials DNP 353
Frédéric A. Perras, Takeshi Kobayashi, and Marek Pruski

20 DNP-enhanced Solid-state NMR Spectroscopy of Active Pharmaceutical Ingredients 373
Li Zhao, Arthur C. Pinon, Lyndon Emsley, and Aaron J. Rossini

21 In Vivo Hyperpolarized 13C MRS and MRI Applications 405
Irene Marco-Rius and Arnaud Comment

22 Dissolution Dynamic Nuclear Polarization 421
Walter Köckenberger

Index 435