Handbook of Natural Toxins, Volume 8: Bacterial Toxins and Virulence Factors in Disease

by Joel Moss

Overview

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria

Product Details

ISBN-13:	9781040191965
Publisher:	CRC Press
Publication date:	03/21/1995
Sold by:	Barnes & Noble
Format:	eBook
Pages:	664
File size:	9 MB

Table of Contents

Biosynthesis and targeting of pertussis toxin; diphthamide - the toxin target in protein synthesis elogation factor 2; leukocidines; heat-stable enterotoxin of escherichia coli; therapeutic effects of botulinum toxins; endotoxin - a mediator of and potential therapeutic target; zot and ace toxins of vibrio cholerae; ADP-ribosylation factors - a family of guanine nucleotide-binding proteins that activate cholera toxin and regulate vesicular transport; liposomes and vehicles for vaccines; GTP-binding proteins as the substrate of pertussis toxin-catalyzed ADP-ribosylation; modification of actin and rho proteins by clostridial ADP-ribosylating toxins; muramyl peptides as exotoxins - bordetella tracheal cytotoxin; adenylyl cyclase toxin from bordetella pertussis; clostridium difficile and its toxins; structure and function of e. coli heat labile enterotoxin and cholera toxin B-pentamer; anthrax toxins; the diphtheria toxin receptor; bacterial ADP-ribosyltransferases; bordetella pertussis - determinants of virulence; shiga and shiga-like (vero) toxins; cholera toxin and related enterotoxins of gram-negative bacteria.

Editorial Reviews

This is the latest in a series of books describing the structure, function, and biogenesis of bacterial toxins with ADP-ribosyltransferase activity. The comparison of several toxin crystal structures has lead to new insights that are summarized in well-documented detail. The purpose is to provide detailed and up-to-date information of the structure and function of toxins relative to bacterial pathogenesis and virulence. This important and timely review summarizes in concise and well-illustrated chapters the molecular mechanisms involved in binding, entry, and intoxication of eukaryotic cells. The book is intended as a comprehensive review for students and scientists involved in studying eukaryotic cellular signaling and metabolism, bacterial pathogenesis, protein structure and function, and ADP-ribosylating enzymes. Important features include several illustrations of toxin structure, tables comparing and aligning protein sequences, and models for catalysis and intoxication. This gives the reader an up-to-date perspective on domain structure and its relevance to cellular toxicity. This useful collection of chapters summarizes the most current information about an important family of bacterial proteins. The emphasis on structure and function provides a good framework for students and scientists interested in cell biology, bacterial pathogenesis, protein translocation, and the therapeutic uses of toxic molecules.

Dara W. Frank

A state-of-the-art reference work detailing the ways bacterial toxins subvert cellular metabolism and signaling. Reviews virulence factors and describes toxin tools for both experimental studies and clinical therapy. Chapters by 51 contributors include: therapeutic effects of botulinum toxins, liposomes as vehicles for vaccines, the diphtheria toxin receptor, diversity of action in the enterotoxin family, biosynthesis of pertussis toxin, anthrax toxins, and endotoxin as a potential therapeutic target for septic shock. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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