Harper's Illustrated Biochemistry, 28th Edition / Edition 28

by Robert Murray, David Bender, Robert K. Murray, Victor W. Rodwell, Victor Rodwell

Overview

The biochemistry text that every medical student must own—now in full color!

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.

The Twenty-Eighth Edition has undergone sweeping changes — including a conversion to full-color artwork and the substantial revision and updating of every chapter — all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.

Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic.

NEW to this edition:

• Full-color presentation, including 600+ illustrations
• Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered
• Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions
• A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals
• NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery

Product Details

ISBN-13:	9780071625913
Publisher:	McGraw-Hill Medical Publishing Division
Publication date:	06/02/2009
Series:	LANGE Basic Science Series
Edition description:	Older Edition
Pages:	704
Product dimensions:	8.50(w) x 10.90(h) x 1.10(d)

About the Author

Robert K. Murray, MD, PhD,

Professor (Emeritus) of Biochemistry,

University of Toronto

David A. Bender, PhD,

Sub-Dean, University College Medical School,

Senior Lecturer in Biochemistry,

Department of Structural and Molecular Biology and

Division of Medical Education,

University College London

Kathleen M. Botham, PhD, DSc,

Professor of Biochemistry, Royal Veterinary

College, University of London

Peter J. Kennelly, PhD,

Professor and Head, Department of Biochemistry,

Virginia Polytechnic Institute and State University,

Blacksburg, Virginia

Victor W. Rodwell, PhD,

Emeritus Professor of Biochemistry, Purdue University, West Lafayette,

Indiana

P. Anthony Weil, PhD,

Professor of Molecular Physiology and Biophysics,

Vanderbilt University School of Medicine,

Nashville, Tennessee

Co-Authors:

Daryl K. Granner, MD,

Emeritus Professor of Molecular Physiology and Biophysics

and Medicine,

Vanderbilt University, Nashville, Tennessee

Peter L. Gross MD, MSc, FRCP(C),

Associate Professor, Department of Medicine,

McMaster University

Frederick W. Keeley, PhD,

Associate Director and Senior Scientist, Research Institute,

Hospital for Sick Children, Toronto, and Professor,

Department of Biochemistry, University of Toronto

Peter A. Mayes, PhD, DSc,

Emeritus Professor of Veterinary Biochemistry, Royal Veterinary College, University of London

Margaret L. Rand, PhD,

Associate Senior Scientist, Hospital for Sick Children, Toronto,

and Professor, Departments of Laboratory Medicine and Pathobiology

and Department of Biochemistry, University of Toronto

Table of Contents

	Authors	vii
	Preface	ix
1.	Biochemistry & Medicine	1
2.	Water & pH	5
Section I.	Structures & Functions of Proteins & Enzymes	14
3.	Amino Acids & Peptides	14
4.	Proteins: Determination of Primary Structure	21
5.	Proteins: Higher Orders of Structure	30
6.	Proteins: Myoglobin & Hemoglobin	40
7.	Enzymes: Mechanism of Action	49
8.	Enzymes: Kinetics	60
9.	Enzymes: Regulation of Activities	72
Section II.	Bioenergetics & the Metabolism of Carbohydrates & Lipids	80
10.	Bioenergetics: The Role of ATP	80
11.	Biologic Oxidation	86
12.	The Respiratory Chain & Oxidative Phosphorylation	92
13.	Carbohydrates of Physiologic Significance	102
14.	Lipids of Physiologic Significance	111
15.	Overview of Metabolism	122
16.	The Citric Acid Cycle: The Catabolism of Acetyl-CoA	130
17.	Glycolysis & the Oxidation of Pyruvate	136
18.	Metabolism of Glycogen	145
19.	Gluconeogenesis & Control of the Blood Glucose	153
20.	The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism	163
21.	Biosynthesis of Fatty Acids	173
22.	Oxidation of Fatty Acids: Ketogenesis	180
23.	Metabolism of Unsaturated Fatty Acids & Eicosanoids	190
24.	Metabolism of Acylglycerols & Sphingolipids	197
25.	Lipid Transport & Storage	205
26.	Cholesterol Synthesis, Transport, & Excretion	219
27.	Integration of Metabolism--the Provision of Metabolic Fuels	231
Section III.	Metabolism of Proteins & Amino Acids	237
28.	Biosynthesis of the Nutritionally Nonessential Amino Acids	237
29.	Catabolism of Proteins & of Amino Acid Nitrogen	242
30.	Catabolism of the Carbon Skeletons of Amino Acids	249
31.	Conversion of Amino Acids to Specialized Products	264
32.	Porphyrins & Bile Pigments	270
Section IV.	Structure, Function, & Replication of Informational Macromolecules	286
33.	Nucleotides	286
34.	Metabolism of Purine & Pyrimidine Nucleotides	293
35.	Nucleic Acid Structure & Function	303
36.	DNA Organization, Replication, & Repair	314
37.	RNA Synthesis, Processing, & Modification	341
38.	Protein Synthesis & the Genetic Code	358
39.	Regulation of Gene Expression	374
40.	Molecular Genetics, Recombinant DNA, & Genomic Technology	396
Section V.	Biochemistry of Extracellular & Intracellular Communication	415
41.	Membranes: Structure & Function	415
42.	The Diversity of the Endocrine System	434
43.	Hormone Action & Signal Transduction	456
Section VI.	Special Topics	474
44.	Nutrition, Digestion, & Absorption	474
45.	Vitamins & Minerals	481
46.	Intracellular Traffic & Sorting of Proteins	498
47.	Glycoproteins	514
48.	The Extracellular Matrix	535
49.	Muscle & the Cytoskeleton	556
50.	Plasma Proteins & Immunoglobulins	580
51.	Hemostasis & Thrombosis	598
52.	Red & White Blood Cells	609
53.	Metabolism of Xenobiotics	626
54.	The Human Genome Project	633
	Appendix	639
	Index	643

Editorial Reviews

2 Stars from Doody