Harper's Textbook of Pediatric Dermatology

Harper's Textbook of Pediatric Dermatology

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The third edition of this highly regarded text continues to provide a comprehensive resource for pediatric dermatologists. The book offers evidence-based diagnosis and treatment recommendations and covers both common and rare conditions, including emerging conditions and research, especially at the genetic level. A refreshing new text design makes the book more accessible, and new editors and contributors bring a distinctly international perspective to the work.

Product Details

ISBN-13: 9781444345377
Publisher: Wiley
Publication date: 07/28/2011
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 2816
Sales rank: 1,185,132
File size: 214 MB
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About the Author

Alan Irvine, MBBS, MD, Associate Professor and Consultant Pediatric Dermatologist, University of Dublin and Our Lady's Hospital for Sick Children, Dublin, Ireland

Albert Yan, MD, Assistant Professor, Director of Pediatric Dermatology, Children's Hospital of Philadelphia, University of Pennsylvania, USA. Dr Yan is also President-elect of the Society of Pediatric Dermatology

Peter Hoeger, MD, Professor and Head of Pediatric Demratology, Cathjolic Children's Hospital, Hamburg and Department of Dermatology, University of Hamburg, Germany

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Table of Contents

List of Contributors, xiii

Preface to the Third Edition, xxv

Acknowledgements, xxvii

List of Abbreviations, xxix


Part 1 The Development of Paediatric Dermatology as a Medical Sub-speciality

1 The History of Paediatric Dermatology, 1.1
John Harper

Part 2 The Newborn

2 Embryogenesis of the Skin, 2.1
Karen A. Holbrook

3 Physiology of Neonatal Skin, 3.1
Peter H. Hoeger

4 The Role of Histopathology in Paediatric Dermatopathology, 4.1
Marian Malone

5 Skin Care of the Newborn, 5.1
Jean-François Stalder

6 Common Transient Neonatal Dermatoses, 6.1
Franck Boralevi & Alain Taïeb

7 Disorders of Subcutaneous Tissue in the Newborn, 7.1
Susan J. Bayliss & Roy Colven

8 Cutaneous Manifestations of Congenital Infections, 8.1
Peter H. Hoeger

9 Acquired Neonatal Infections, 9.1
Nico G. Hartwig, Arnold P. Oranje, Dirk Van Gysel & Marinus C.G. van Praag

10 Developmental Abnormalities, 10.1
Henning Hamm

11 Differential Diagnosis of Neonatal Erythroderma, 11.1
Hagen Ott & Peter H. Hoeger

12 Collodion Baby, 12.1
Edel A. O'Toole & David P. Kelsell

13 Harlequin Ichthyosis, 13.1
Edel A. O'Toole & David P. Kelsell

14 Neonatal Lupus Erythematosus, 14.1
Sara J. Brown & Rosemarie M. Watson

15 Restrictive Dermopathy, 15.1
David G. Paige

16 Congenital Erosive and Vesicular Dermatosis, 16.1
Bernard A. Cohen

17 Iatrogenic Disorders of the Newborn, 17.1
Elia F. Maalouf & Wilson B. Lopez

Part 3 Napkin Dermatitis

18 General Aspects of Napkin Dermatitis, 18.1
Arnold P. Oranje

19 Causative Factors of Napkin Dermatitis, 19.1
Ernesto Bonifazi

20 Clinical Features and Differential Diagnosis of Napkin Dermatitis, 20.1
Albert C. Yan & Paul J. Honig

21 Management of Napkin Dermatitis, 21.1
Arnold P. Oranje

Part 4 Atopic Dermatitis

22 Epidemiology of Atopic Dermatitis, 22.1
Carsten Flohr & Hywel C.G. Williams

23 Genetics of Atopic Dermatitis, 23.1
Stephan Weidinger & Alan D. Irvine

24 Immunology of Atopic Dermatitis, 24.1
Aideen M. Byrne & Donald Y.M. Leung

25 Immunopharmacological Mechanisms in Atopic Dermatitis, 25.1
Clive B. Archer

26 Microbiology in Atopic Eczema, 26.1
Christina Schnopp & Martin Mempel

27 The Skin Barrier in Atopic Dermatitis, 27.1
Simon G. Danby & Michael J. Cork

28 Clinical Features and Diagnostic Criteria of Atopic Dermatitis, 28.1
Sinéad M. Langan & Hywel C.G. Williams

29 Atopic Dermatitis: Scoring Severity and Quality of Life Assessment, 29.1
M. Susan Lewis-Jones & Carolyn R. Charman

30 Guidelines to Management of Atopic Dermatitis, 30.1
John Harper, Kathrin Giehl & E. Ann Bingham

31 Food Allergy and Eczema, 31.1
Helen E. Cox & Jonathan Hourihane

32 Aeroallergies and Atopic Eczema, 32.1
Ann-Marie Powell, Gideon Lack & Adam Fox

33 Eczema Herpeticum, 33.1
Helen M. Goodyear

34 Psychosocial Aspects of Atopic Dermatitis, 34.1
Margaret DeJong, Ereni Skouta & Mary T. Glover

Part 5 Other Types of Dermatitis

35 Infantile Seborrhoeic Dermatitis, 35.1
Carlo M. Gelmetti & Ramon Grimalt

36 Hypereosinophilic Disorders, 36.1
Nerys M. Roberts & Richard Staughton

37 Pityriasis Alba, 37.1
Nanette B. Silverberg

38 Perioral Dermatitis, 38.1
Ki-Young Suh & Ilona J. Frieden

39 Pompholyx, 39.1
Carlo M. Gelmetti

40 Nummular or Discoid Dermatitis, 40.1
Linda E. De Raeve

41 Seborrhoeic Dermatitis of Adolescence, 41.1
James A.A. Langtry

42 Lichen Simplex Chronicus and Prurigo, 42.1
Howard B. Pride & Mercedes E. Gonzalez

43 Juvenile Plantar Dermatosis, 43.1
John Browning & Alanna Bree

44 Allergic Contact Dermatitis, 44.1
Carsten Flohr & John S. C. English

45 Phytodermatoses, 45.1
Christopher R. Lovell

Part 6 Infections

46 Molluscum Contagiosum, 46.1
Ali Alikhan & Tor Shwayder

47 Human Papillomavirus Infection, 47.1
Zsuzsanna Z. Szalai

48 Herpes Simplex Virus Infections, 48.1
Helen M. Goodyear

49 Viral Exanthems, 49.1
Wynnis L. Tom & Sheila Fallon Friedlander

50 Gianotti-Crosti Syndrome, 50.1
Carlo M. Gelmetti

51 Poxviruses, 51.1
M. Susan Lewis-Jones

52 HIV Infection, 52.1
Neil S. Prose & Coleen K. Cunningham

53 Infective Dermatitis (Skin Manifestations of HTLV Infection), 53.1
Rosalia A. Ballona & Neil B. Prose

54 Pyodermas and Toxin-mediated Syndromes, 54.1
Christian R. Millett, Warren R. Heymann & Steven M. Manders

55 Skin Manifestations of Meningococcal Infection, 55.1
Saul N. Faust, Parviz Habibi & Robert S. Heyderman

56 Pitted Keratolysis, Erythrasma and Erysipeloid, 56.1
Anita P. Sheth

57 Mycobacterial Infections of the Skin, 57.1
Lisa McNally, Huda Al-Ansari & Vas Novelli

58 Bartonella Infections: Bacillary Angiomatosis, Cat Scratch Disease and Bartonellosis, 58.1
Diana B. McShane, Heidi H. Kong & Sarah A. Myers

59 Lyme Borreliosis, 59.1
Susan O'Connell

60 Endemic Treponematoses: Yaws, Pinta and Endemic Syphilis, 60.1
Herman Jan H. Engelkens

61 Rocky Mountain Spotted Fever and Other Rickettsial Infections, 61.1
Daniel J. Sexton

62 Superfi cial Fungal Infections, 62.1
Peter P.M. Mayser & Yvonne Gräser

63 Deep Mycoses and Opportunistic Infections, 63.1
Adrián-Martín Pierini,, María Marta Bujan & Agustina Lanoël

64 Cutaneous Infections in Immunocompromised Children, 64.1
Hagen Ott & Peter H. Hoeger

Part 7 Nutritional Disorders

65 Skin Manifestations of Nutritional Disorders, 65.1
Luz Orozco-Covarrubias & Carola Durán McKinster

Part 8 Tropical Dermatoses

66 Tropical Ulcer, 66.1
Vibhu Mendiratta

67 Leishmaniasis, 67.1
Evelyne Halpert, Gerzain Rodriguez & Carlos Arturo Hernández

68 Cutaneous Larva Migrans, 68.1
Antonia K. Kienast

69 Myiasis, 69.1
Peter H. Hoeger

70 Leprosy (Hansen Disease), 70.1
Sunil Dogra & Amrinder J. Kanwar

Part 9 Stings and Infestations

71 Papular Urticaria, 71.1
Ian F. Burgess

72 Scabies and Lice, 72.1
Julie S. Prendiville

73 Other Noxious and Venomous Creatures, 73.1
Dirk M. Elston

Part 10 Urticaria and the Erythemas

74 Urticaria, 74.1
Christine Léauté-Labrèze, Franck Boralevi & Alain Taïeb

75 Mastocytosis, 75.1
Dirk Van Gysel, Ron H.N. van Schaik & Arnold P. Oranje

76 Annular Erythemas, 76.1
Kimberly A. Horii & Amy J. Nopper

77 Erythema Nodosum and Other Forms of Panniculitis, 77.1
Heather A. Brandling-Bennett & Maria C. Garzon

78 Erythema Multiforme, Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis, 78.1
Lizbeth Ruth A. Intong & Dédée F. Murrell

Part 11 Acne

79 Acne, 79.1
Bodo C. Melnik

Part 12 Psoriasis and Other Papulosquamous Disorders

80 Psoriasis, 80.1
Flora B. de Waard-van der Spek & Arnold P. Oranje

81 Psoriasis: Pathogenesis, 81.1
Flora B. de Waard-van der Spek & Arnold P. Oranje

82 Psoriasis: Treatments, 82.1
Flora B. de Waard-van der Spek, Lisette W.A. van Suijlekom-Smit & Arnold P. Oranje

83 Pityriasis Rubra Pilaris, 83.1
Melinda Jen & Mary Wu Chang

84 Pityriasis Rosea, 84.1
Antonio A.T. Chuh & Vijay Zawar

85 Lichen Planus and Lichen Nitidus, 85.1
Harper N. Price & Andrea L. Zaenglein

86 Lichen Striatus, 86.1
Alain Taïeb & Edouard Grosshans

Part 13 Blistering Disorders

87 Differential Diagnosis of Vesiculobullous Lesions, 87.1
James G.H. Dinulos & Joi B. Carter

88 Infantile Acropustulosis, 88.1
Richard J. Antaya

89 Linear IgA Associated Bullous Disease in Children: Childhood Linear IgA Disease/Chronic Bullous Disease of Childhood, Mixed Immunobullous Disease and IgA Mucous Membrane Pemphigoid, 89.1
Gudula Kirtschig & Fenella Wojnarowska

90 Dermatitis Herpetiformis, 90.1
Jonathan N. Leonard

91 Pemphigus, Pemphigoid and Epidermolysis Bullosa Acquisita, 91.1
J. Henk Sillevis Smitt & Marcel F. Jonkman

Part 14 Skin Nodules

92 Differential Diagnosis of Skin Nodules and Cysts, 92.1
Peter H. Hoeger

93 Granuloma Annulare, 93.1
Cameron T.C. Kennedy

94 Adnexal Disorders, 94.1
Andrew Wang & Robert Sidbury

95 Calcifi cation and Ossifi cation in the Skin, 95.1
Eulalia T. Baselga

96 Knuckle Pads, 96.1
Elaine C. Siegfried

97 Fibromatoses, Hyalinoses and Stiff Skin Syndrome, 97.1
Grazia Mancini, Arnold P. Oranje, Jan C. den Hollander & Moise L. Levy

98 Angiolymphoid Hyperplasia with Eosinophilia, 98.1
Alfons L. Krol

99 Skin Malignancies, 99.1
Adrián-Martín Pierini,, Andrea Bettina Cervini & Marcela Bocian

Part 15 Lymphocytic Disorders and Histiocytosis

100 Pityriasis Lichenoides, 100.1
Ernesto Bonifazi

101 Jessner's Lymphocytic Infi ltrate of the Skin, 101.1
R.M. Ross Hearn

102 Cutaneous Lymphomas, 102.1
Elena Pope & Kenneth Chang

103 Histiocytosis, 103.1
Irene Lara-Corrales and Elena Pope

Part 16 Disorders of Pigmentation

104 Disorders of Pigmentation, 104.1
R.M. Ross Hearn

105 Vitiligo, 105.1
Juliette Mazereeuw-Hautier & Alain Taïeb

Part 17 Photodermatoses and Photoprotection

106 The Idiopathic Photodermatoses, 106.1
James Ferguson

107 Porphyrias, 107.1
Jose M. Mascaro & Henry W. Lim

108 Photoprotection, 108.1
Robin L. Hornung

Part 18 Melanocytic Naevi and Melanoma

109 Melanocytic Naevi and Melanoma, 109.1
Julia A. Newton Bishop

Part 19 Epidermal Naevi and Associated Syndromes

110 Epidermal Naevi, 110.1
Jon A. Dyer

111 Proteus Syndrome, 111.1
John Harper, Kathrin Giehl & Raoul Hennekam

Part 20 Vascular and Lymphatic Anomalies

112 Vascular Malformations, 112.1
Laurence M. Boon, Odile Enjolras, John B. Mulliken, & Miikka Vikkula

113 Infantile Haemangiomas and Other Vascular Tumours, 113.1
Anna L. Bruckner & Ilona J. Frieden

114 Disorders of Lymphatics, 114.1
Sahar Mansour & Peter S. Mortimer


Part 21 Genetic Disorders

115 Principles of Genetics, Mosaicism and Molecular Biology, 115.1
Rudolf Happle

116 Chromosomes and the Skin, 116.1
Christopher P. Barnett & William Reardon

117 Review of Keratin Disorders, 117.1
Maurice A.M. van Steensel & Peter M. Steijlen

118 Epidermolysis Bullosa, 118.1
Jemima E. Mellerio & Jacqueline E. Denyer

119 Kindler Syndrome, 119.1
Anna E. Martinez & Dawn Siegel

120 Mendelian Disorders of Cornification (MEDOC): the Keratodermas, 120.1
Maurice A.M. van Steensel & Peter M. Steijlen

121 Mendelian Disorders of Cornifi cation (MEDOC): the Ichthyoses, 121.1
Daniel Hohl & Mary Williams

122 Mendelian Disorders of Cornifi cation (MEDOC): the Erythrokeratodermas, 122.1
Daniel Hohl, Stephanie Christen-Zaech & Baruk Mevorah

123 Keratosis Pilaris, 123.1
Arnold P. Oranje & Dirk Van Gysel

124 Netherton Syndrome, 124.1
Wei-Li Di & John Harper,

125 Darier Disease, 125.1
Susan M. Burge

126 Porokeratosis, 126.1
Leslie Castelo-Soccio

127 Ectodermal Dysplasias, 127.1
Yuka Asai & Alan D. Irvine

128 The Neurofi bromatoses, 128.1
Amy Theos, Kevin P. Boyd & Bruce R. Korf

129 Tuberous Sclerosis, 129.1
John P. Osborne & Andrew J. Green

130 Incontinentia Pigmenti, 130.1
Dian Donnai

131 Hypomelanosis of Ito/Pigmentary mosaicism, 131.1
Saleem M. Taibjee & Celia Moss

132 Gorlin (Naevoid Basal Cell Carcinoma) Syndrome, 132.1
Peter A. Farndon

133 Focal Dermal Hypoplasia, 133.1
Amarilis Sanchez-Valle, V. Reid Sutton & Ignatia B. Van den Veyver,

134 Premature Ageing Syndromes, 134.1
Helga V. Toriello

135 Xeroderma Pigmentosum, Cockayne Syndrome and Trichothiodystrophy, 135.1
Steffen Emmert

136 Rothmund-Thomson Syndrome, Bloom Syndrome, Dyskeratosis Congenita, Fanconi Anaemia, 136.1
Celia Moss

137 Genetic Diseases that Predispose to Malignancy, 137.1
Julie V. Schaffer

138 Inherited Disorders of Pigmentation, 138.1
Eli Sprecher & Dov Hershkovitz

139 Prenatal Diagnosis of Inherited Skin Disorders, 139.1
John A. McGrath

140 Skin Gene and Cell Therapy, 140.1
Matthias Titeux & Alain Hovnanian

Part 22 Disorders of Fat Tissue

141 Disorders of Fat Tissue, 141.1
Marc Lacour

Part 23 Disorders of Connective Tissue

142 Ehlers–Danlos Syndromes, 142.1
Nigel P. Burrows, Navjeet Sidhu-Malik & Heather N. Yeowell

143 Cutis Laxa, 143.1
Richard J. Antaya

144 Pseudoxanthoma Elasticum, 144.1
Anne Han & Mark Lebwohl

145 Buschke-Ollendorff Syndrome, Marfan Syndrome, Osteogenesis Imperfecta, Anetodermas and Atrophodermas, 145.1
Marc Lacour

146 Striae, 146.1
Manjunatha Kalavala & Magdalene Dohil

Part 24 The Oral Cavity

147 Diseases of the Oral Mucosa and Tongue, 147.1
Jane Luker & Crispian Scully

Part 25 Hair and Nails

148 Hair Disorders, 148.1
Elise A. Olsen

149 Alopecia Areata, 149.1
Kerstin Foitzik-Lau

150 Nail Disorders, 150.1
Antonella Tosti, & Bianca M. Piraccini

Part 26 Genitourinary Problems in Children

151 Genital Disease in Children, 151.1
Gayle O. Fischer

152 Vulvovaginitis and Lichen Sclerosus, 152.1
Sallie M. Neill

153 Sexually Transmitted Diseases in Children and Adolescents, 153.1
Arnold P. Oranje, Robert A.C. Bilo & Nico G. Hartwig

Part 27 Physical and Sexual Abuse in Children

154 Non-accidental Injury (Physical Abuse), 154.1
Antonia K. Kienast

155 Child Maltreatment: Sexual Abuse, 155.1
Sarah M. Frioux & Cindy Christian

Part 28 Systemic Diseases

156 Sweet Syndrome, 156.1
Peter von den Driesch

157 Crohn Disease and Orofacial Granulomatosis, 157.1
Billy Bourke, Paddy Fleming, & Claire Healy

158 Sarcoidosis, 158.1
Julie L. Cantatore-Francis & Julie V. Schaffer

159 Amyloidosis, 159.1
Teri A. Kahn

160 Schönlein-Henoch Purpura, 160.1
Hagen Ott

161 Acute Haemorrhagic Oedema of the Skin in Infancy, 161.1
Alain Taïeb & Valérie Legrain

162 Purpura Fulminans, 162.1
Michael Levin, Brian Eley & Saul N. Faust

163 Urticarial Vasculitis, 163.1
Heather A. Brandling-Bennett & Marilyn G. Liang

164 Erythema Elevatum Diutinum, 164.1
Aimee C. Smidt & Sarah L. Chamlin

165 Pigmented Purpura, 165.1
Allison L. Jensen & Sheryll L. Vanderhooft

166 Erythromelalgia, 166.1
Justin Daniels

167 Wegener Granulomatosis, Polyarteritis Nodosa, Microscopic Polyangiitis, Behçet Disease and Relapsing Polychondritis, 167.1
Paul A. Brogan & E. Jane Tizard

168 Kawasaki Disease, 168.1
Wynnis L. Tom, Tomisaku Kawasaki & Jane C. Burns

169 Inherited Metabolic Disorders and the Skin, 169.1
Johannis B.C. de Klerk & Arnold P. Oranje

170 Cystic Fibrosis, 170.1
Rod Phillips

171 Carotenaemia, 171.1
Peter T. Clayton & Emma J. Footitt

172 Cutaneous Manifestations of Endocrine Disease, 172.1
Peter A. Hogan

173 Morphoea (Localized Scleroderma), 173.1
Lisa Weibel & John Harper

174 Systemic Sclerosis in Childhood, 174.1
Christopher P. Denton & Carol M. Black

175 Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus and Juvenile Dermatomyositis, 175.1
Despina Eleftheriou & Patricia Woo

176 Periodic Fever Syndromes, 176.1
Juan C. Salazar & Henry M. Feder Jr

177 Immunodefi ciency Syndromes, 177.1
Julie V. Schaffer & Amy S. Paller

178 Graft-Versus-Host Disease, 178.1
John Harper & Paul Veys

Part 29 Psychological Aspects of Skin Disease in Children

179 Coping with the Burden of Chronic Skin Disease, 179.1
Elisa S. Gallo & Sarah L. Chamlin

180 Physiological Habits, Self-Mutilation and Factitious Disorders, 180.1
Arnold P. Oranje, Jeroen Novak & Robert A.C. Bilo

Part 30 Therapeutics and Poisoning

181 Principles of Paediatric Dermatological Therapy, 181.1
Dennis P. West, Candrice Heath, Ann Cameron Haley, Anne Mahoney & Giuseppe Micali

182 The Use of Emerging Biological Treatments in Children, 182.1
Polly Livermore & Clarissa Pilkington

183 Hypersensitivity Reactions to Drugs, 183.1
Hagen Ott

184 Poisoning and Paediatric Skin, 184.1
Giuseppe Micali, Stephanie A. St Pierre, Erika E. Reid & Dennis P. West

Part 31 Dermoscopy in Pediatric Skin

185 Dermoscopy of Melanocytic Lesions in the Paediatric Population, 185.1
Jennifer L. DeFazio, Ralph P. Braun & Ashfaq A. Marghoob

Part 32 Surgical and Laser Therapies

186 Surgical Principles and Techniques in Paediatric Dermatology, 186.1
Léon N.A. van Adrichem

187 More Complex Skin Surgery, 187.1
Paul Morris, Guy Thorburn & Loshan Kangesu

188 Laser Treatment for Cutaneous Vascular Anomalies, 188.1
Samira Syed, Jane Linward & John Harper

189 The Use of Resurfacing, Pigment and Depilation Lasers in Children, 189.1
Andrew C. Krakowski & Lawrence F. Eichenfield

190 Sedation and Anaesthesia, 190.1
Yuin-Chew Chan & Lawrence F. Eichenfield

191 Treatment of Congenital Melanocytic Naevi, 191.1
Neta Adler & Bruce S. Bauer

Part 33 Nursing Care of Paediatric Skin

192 Nursing Care of Paediatric Skin, 192.1
Jane White, Jane Linward, Jacqueline Denyer & Bisola Laguda


What People are Saying About This

From the Publisher

Die vorige Auflage war hervorragend, und diese ist es auch Trotzdem hat sich vieles geändert: Das gesamte Editorenteam wurde ausgetauscht, wobei nun Irvine, Hoeger und Yan das ursprüngliche Trio Harper, Oranje und Prose ersetzen. Zwar wird der Harper oft als "der kleine Rook" bezeichnet, das Textbook of Pediatric Dermatology ist jedoch wesentlich internationaler mit zahlreichen brillanten Autoren. Viele neue Kapitel sind hinzugekommen, die meisten anderen wurden komplett überarbeitet. Darüber hinaus präsentiert sich das Layout nunmehr zeitgenössischer, mit mehrfarbiger Kapitel-
und Überschriftengestaltung. Die Abbildungen sind gut, insbesondere, wenn man die Seltenheit der abgebildeten Erkrankungen bedenkt. Jemand, der dieses Buch hat, benötigt keine weiteren Werke zum Thema Genodermatosen oder neonatale Dermatologie. Beide Themenbereiche werden mit beachtlichem Tiefgang bearbeitet und die genetische Information ist am letzten Stand. Allein das Thema "Atopische Dermatitis" gliedert sich in 13 Kapitel,
was eine Umfassendheit beweist, die üblicherweise Werken vorbehalten ist, die sich ausschließlich mit diesem Thema beschäftigen. Ganz offensichtlich ist dies ein großes Referenzwerk, und weder eignet sich das Format für die vielzitierte Kitteltasche, noch sind die > 3000 Seiten zum Durchlesen von A-Z gedacht; wohl aber für eine fundierte Übersicht über so gut wie jede denkbare Hauterkrankung des Kindesalters (JDDG 06/2012).

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