Immunity

by William E. Paul

Overview

A leading figure in immunology takes readers inside the remarkably powerful human immune system.

Winner of the CHOICE Outstanding Academic Title of the Choice ACRL

The immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the agonies of AIDS.

Packed with illustrations, stories from Dr. William E. Paul’s distinguished career, and fascinating accounts of scientific discovery, Immunity presents the three laws of the human immune system—universality, tolerance, and appropriateness—and explains how the system both protects and harms us. From the tale of how smallpox was overcome and the lessons of the Ebola epidemic to the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must take advantage of cutting-edge technologies and promising new tools in immunological research.

Product Details

ISBN-13:	9781421418025
Publisher:	Johns Hopkins University Press
Publication date:	11/15/2015
Sold by:	Barnes & Noble
Format:	eBook
Pages:	280
File size:	2 MB
Age Range:	18 Years

About the Author

William E. Paul, MD (1936–2015) was the chief of the Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. He received his medical degree from the State University of New York Downstate Medical Center. A past president of the American Association of Immunologists and the American Society for Clinical Investigation, he was also a member of the National Academy of Sciences and its Institute of Medicine and a Fellow of the American Academy of Arts and Sciences.

Table of Contents

Preface
Part One
1. Defense and Danger
2. Tracing an Immune Response
3. The Laws of Immunology
4. Growing Up and Learning Immunology
Part Two
5. Vaccines and Serum Therapy
6. How Is Specificity Achieved?
7. Immunology's "Eureka"
8. How Does Each Lymphocyte Develop a Distinct Receptor?
9. B Cells and T Cells Recognize Different Types of Antigens
10. My Foray into the Specificity Problem
11. Genes and Immune Responses
12. The Laboratory of Immunology and the T-Cell Receptor
Part Three
13. What Is Tolerance?
14. How Does Tolerance Develop?
15. Regulatory T Cells and the Prevention of Autoimmunity
Part Four
16. Different Structures, Different Functions
17. Specific Types of Infections, Specific Types of T-Cell Responses
18. Our Discovery of IL-4 and the Cells That Make It
19. CD8 T Cells
20. Dendritic Cells
Part Five
21. An "Ancient" Immune Response Controls" Modern" Immunity
22. The Microbiome and Innate Immunity
23. Evolution of the Immune System and Innate Lymphoid Cells
Part Six
24. The HIV Epidemic and the Office of AIDS Research
25. How the Immune System Causes Rheumatoid Arthritis and Lupus
26. Allergy and Asthma
27. Interleukin-4 and Allergy
28. Can the Immune System Control Cancer?
29. New Parts for Old
30. Julien
Conclusion
Epilogue
Acknowledgments
Notes
Index

What People are Saying About This

Daniel M. Davis

A treasure trove of information, this wonderful book should broadly appeal to anyone interested in human health and disease. There is no competing volume that covers such breadth of immunology at this personal level. A tour de force.

Arnold J. Levine

Paul recounts in a clear fashion the ideas, experiments and insights that have led us to our present day understanding of immunity. Along the way we encounter new viruses, autoimmunity, and the latest insights in cancer immunotherapy.

From the Publisher

A treasure trove of information, this wonderful book should broadly appeal to anyone interested in human health and disease. There is no competing volume that covers such breadth of immunology at this personal level. A tour de force.
—Daniel M. Davis, University of Manchester, author of The Compatibility Gene: How Our Bodies Fight Disease, Attract Others, and Define Our Selves

Dr. Paul has lived the modern history of basic and applied immunology. His warm, down-to-earth style and deep insight into biology lead the reader on a fascinating journey in understanding these diverse processes from the vantage point of a discovery scientist.
—Hyam Levitsky, MD, Johns Hopkins University School of Medicine

Immunity is at once an informative history of immunology with numerous personal asides and a brilliant introduction to the wonders of this key field of medical science. The novice can learn immunology from this book while the professional will appreciate Dr. Paul’s role in the history and enjoy his erudition and judgment.
—David Baltimore, California Institute of Technology, Nobel Prize Winner in Physiology or Medicine, 1975

Paul recounts in a clear fashion the ideas, experiments and insights that have led us to our present day understanding of immunity. Along the way we encounter new viruses, autoimmunity, and the latest insights in cancer immunotherapy.
—Arnold J. Levine, Institute for Advanced Study

David Baltimore

Immunity is at once an informative history of immunology with numerous personal asides and a brilliant introduction to the wonders of this key field of medical science. The novice can learn immunology from this book while the professional will appreciate Dr. Paul’s role in the history and enjoy his erudition and judgment.

Hyam Levitsky

Dr. Paul has lived the modern history of basic and applied immunology. His warm, down-to-earth style and deep insight into biology lead the reader on a fascinating journey in understanding these diverse processes from the vantage point of a discovery scientist.

Arnold Levine

"Paul recounts in a clear fashion the ideas, experiments and insights that have led us to our present day understanding of immunity. Along the way we encounter new viruses, autoimmunity, and the latest insights in cancer immunotherapy."

Editorial Reviews

An excellent overview of what science knows about immunology today.
—Science-Based Medicine

Written by a prominent researcher and scholar who not only followed the history of immunology but also participated in its creation, Immunity could be considered as an excellent summary of the classical, pre-systemic, immunological era.
—Metascience

It is well written, informative and gives detailed descriptions even down to defining platelets—sometimes we make the assumption that individuals know these details but the author has pre-empted this and provided ample explanations, which in essence will widen his audience . . . I would recommend this book to students, healthcare assistants, clinicians, and nurse specialists working within all areas.
—Nursing Times

[Immunity] is a remarkably clear, concise, well-written, and well-organized presentation of the components and interactions of the multiple parts of the immune system as it functions to protect the body from disease or foreign agents when functioning properly—or cause disease when malfunctioning . . . Written for the general public and for potential students of immunology, it could also serve as an accompanying text for any immunology course . . . Essential.
—R. S. Kowalczyk, University of Michigan, Choice

From the Publisher

An excellent overview of what science knows about immunology today.

Science-Based Medicine

It is well written, informative and gives detailed descriptions even down to defining platelets—sometimes we make the assumption that individuals know these details but the author has pre-empted this and provided ample explanations, which in essence will widen his audience . . . I would recommend this book to students, healthcare assistants, clinicians, and nurse specialists working within all areas.

Nursing Times

Written by a prominent researcher and scholar who not only followed the history of immunology but also participated in its creation, Immunity could be considered as an excellent summary of the classical, pre-systemic, immunological era.

Metascience

[Immunity] is a remarkably clear, concise, well-written, and well-organized presentation of the components and interactions of the multiple parts of the immune system as it functions to protect the body from disease or foreign agents when functioning properly—or cause disease when malfunctioning . . . Written for the general public and for potential students of immunology, it could also serve as an accompanying text for any immunology course . . . Essential.

Choice - R. S. Kowalczyk

"An excellent overview of what science knows about immunology today."

Science-Based Medicine - Harriet Hall