Ion Channels Down Under

by Dominic Geraghty (Editor), Lachlan D. Rash (Editor)

Overview

Ion Channels Down Under, Volume 79 provides up-to-date information on ion channel pharmacology, their pharmacological modulators, and their role in a diverse range of poorly treated medical conditions. This new volume covers specific topics relating to Receptors and the Diversity in their Structure and Pharmacology, Acid-Sensing Ion Channel Pharmacology, Past, Present and Future, Sodium Channels and Venom Peptide Pharmacology, the Role of Non-Neuronal TRPV4 Signaling in Inflammatory Processes, and Genetically Encoded Calcium Indicators as Probes to Assess the Role of Calcium Channels in Disease and for High-Throughput Drug Discovery. Contributors in this series include prominent scientists and highly-recognized experts with major accomplishments in the field of ion channel pharmacology. Topics covered include the role of ion channels in health and disease, ion channels as therapeutic targets and the molecular pharmacology of ion channels. - Provides a must read book on ion channel pharmacology - Contains up-to-date information on a number of ion channels, their pharmacological modulators, and their role in a diverse range of poorly treated medical conditions - Contains contributions from prominent scientists and highly-recognized experts with major accomplishments in the field

Product Details

ISBN-13:	9780128104149
Publisher:	Elsevier Science & Technology Books
Publication date:	05/18/2017
Series:	Advances in Pharmacology , #79
Sold by:	Barnes & Noble
Format:	eBook
Pages:	336
File size:	24 MB
Note:	This product may take a few minutes to download.

About the Author

Professor Dom Geraghty graduated with a BSc Honours degree in Pharmacology from the National University of Ireland, University College, Dublin, in 1981, and completed his PhD at Deakin University, Victoria, in 1988. Dominic is president of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) the premier society for the study of medicines and chemicals in our Asia-Pacific region. His primary research interest is the role of TRPV1 channels in health and disease, particularly immune cell and platelet function. He has been at the University of Tasmania for over 25 years where he is currently the Deputy Chair of Academic Senate.
Dr Lachlan Rash is a senior lecturer in pharmacology and ion channel researcher at the School of Biomedical Sciences, The University of Queensland. After receiving his PhD in Pharmacology at Monash University (Victoria, Australia) studying the pharmacology of Australian spider venoms, he trained in the molecular pharmacology of acid-sensing ion channels and voltage-gated sodium channels in the group of Michel Lazdunski (IMPC-CNRS) in France. His primary research interest is the discovery, characterization, mechanism of action and structure-activity relationships of novel ion channel ligands from animal venoms. This fundamental work underpins projects to develop selective acid-sensing ion channel and voltage-gated sodium channel research tools and potential therapeutic leads in the areas of pain, inflammation and neurodegeneration.

Table of Contents

1. GABAA Receptors and the Diversity in their Structure and PharmacologyHan Chow Chua and Mary Chebib2. Acid-Sensing Ion Channel Pharmacology, Past, Present and Future…Lachlan D. Rash3. Sodium Channels and Venom Peptide PharmacologyMathilde Israel, Bryan Tay, Jennifer Deuis and Irina Vetter4. Role of Non-Neuronal TRPV4 Signaling in Inflammatory ProcessesPradeep Rajasekhar, Daniel P. Poole and Nicholas A. Veldhuis5. Genetically Encoded Calcium Indicators as Probes to Assess the Role of Calcium Channels in Disease and for High-Throughput Drug DiscoveryJohn J. Bassett and Gregory R. Monteith6. TRPV1 Channels in Immune Cells and Hematological MalignanciesSofia Omari, Murray Adams and Dominic Geraghty7. Modulation of Ion Channels by Cysteine-Rich Peptides: From Sequence to StructureMehdi Mobli, Eivind A.B. Undheim and Lachlan D. Rash8. Glycine Receptor Drug DiscoveryJoseph W. Lynch, Yan Zhang, Sahil Talwar and Argel Estrada-Mondragon9. Voltage-Gated Sodium Channel Pharmacology - Insights from Molecular Dynamics SimulationsRong Chen, Amanda Buyan and Ben Corry10. Physiology and Pharmacology of Ryanodine Receptor Calcium Release ChannelsAngela F. Dulhunty, Philip G. Board, Nicole A. Beard and Marco G. Casarotto

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From the Publisher

Concise information on ion channel pharmacology with supporting references by prominent scientists and highly-recognized experts in the field