Membrane Separations in Biotechnology

by William K. Wang (Editor)

Overview

This text details the relationship between membrane technology and bioprocesses, discussing applications. This second edition refines and optimizes key features of the first edition - and features new illustrative case studies. The book examines advantages and disadvantages of using standard and new membrane technologies; analyzes a wide range of applications, including cell culture harvesting and product and process validation techniques; and more.

Product Details

ISBN-13:	9780367397432
Publisher:	Taylor & Francis
Publication date:	09/05/2019
Edition description:	2nd ed.
Pages:	416
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

William K. Wang is an Assistant Director at GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania. The author, coauthor, or coeditor of several journal articles, scientific papers, and books, and a member of the American Chemical Society, Dr. Wang received the B.S.E. degree (1987) from the University of Pennsylvania, Philadelphia, and the M.S. (1990) and the Ph.D. (1993) degrees from the University of Rochester, New York.

Table of Contents

Series Introduction iii

Preface v

Contributors ix

1 Protein Transport in Ultrafiltration Hollow-Fiber Bioreactors for Mammalian Cell Culture Marek Labecki Bruce D. Bowen James M. Piret 1

2 Vortex Flow Filtration for Cell Separation in Bioreactor Operations Georg Roth Clayton E. Smith Gary M. Schoofs Tana J. Montgomery Jenifer L. Ayala Thomas J. Monica Francisco J. Castillo Joseph I. Horwitz 63

3 Crossflow Membrane Filtration of Fermentation Broth Gregory Russotti Kent E. Göklen 85

4 Crossflow Microfiltration with Backpulsing Robert H. Davis 161

5 Effects of Different Membrane Modular Systems on the Performance of Crossflow Filtration of Pichia pastoris Suspensions Vicki L. Schlegel Michael Meagher 189

6 Filter Applications in Product Recovery Processes Paul K. Ng Alfred C. Dadson Jr. G. Michael Connell Bernard P. Bautista 205

7 Ultrafiltration Membranes in the Vaccine Industry Peter Schu Gautam Mltra 225

8 Protein Purification by Affinity Ultrafiltration Igor Yu. Galaev Bo Mattiasson 243

9 Process Development for the Isolation of a Recombinant Immunofusion Protein Using a Membrane Adsorber William K. Wang Harold G. Monbouquette W. Courtney McGregor 263

10 High-Performance Tangential-Flow Filtration Andrew L. Zydney Robert van Reis 277

11 Virus Removal by Ultrafiltration: A Case Study with Diaspirin Crosslinked Hemoglobin (DCLHb) Kristen F. Ogle Mahmood R. Azari 299

12 Scaleup and Virus Clearance Studies on Viral Filtration in Monoclonal Antibody Manufacture Ping Yu Huang John Peterson 327

13 Virus Removal by Tangential-Flow Filtration for Protein Therapeutics Brian D. Kelley Jon T. Petrone 351

Index 397

Editorial Reviews

Describes the approaches to membrane technology used by the individual contributors to improve the performance and productivity of their bioprocesses. The 13 chapters discuss such applications as cell culture harvesting, product purification, and process validation. The second edition reflects refinements in technology and new membrane applications, and places more emphasis on pharmaceutical applications. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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