Modern Concepts of Focal Epileptic Networks

by Premysl Jiruska (Editor), Marco De Curtis (Editor), John G. R. Jefferys (Editor)

Overview

This volume of International Review of Neurobiology concentrates on modern concepts of focal epileptic networks. The volume addresses specific topics such as seizures (including transition and termination), limbic networks, alteration of metabolism, and neocortical focus and malformation of cortical development, among others. Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews, and thematic volumes that focus on recent progress in a specific area of neurobiology research. - Our knowledge about the mechanisms involved in pathophysiology of epilepsy has rapidly expanded during last decade - This special volume brings overview about modern concepts of epileptic focus organization and about the altered neural network dynamics which results in propensity of the brain tissue to generate spontaneous and repeated seizures

Product Details

ISBN-13:	9780124199576
Publisher:	Elsevier Science & Technology Books
Publication date:	07/24/2014
Series:	International Review of Neurobiology , #114
Sold by:	Barnes & Noble
Format:	eBook
Pages:	364
File size:	28 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Premysl Jiruska is Associate Professor at the Institute of Physiology, Academy of Sciences of Czech Republic. He received his M.D. and Ph.D. degrees from Charles University in Prague Czech Republic. fter completing his PhD, he undertook a postdoctoral position in the group of Prof. John Jefferys at the University of Birmingham, focusing on experimental epilepsy research. In 2008 he was awarded a personal Sir Desmond Pond fellowship by Epilepsy Research UK to conduct independent research on the mechanisms involved in the transition from normal brain activity to seizure. Currently, in his research he focuses on mechanisms of ictogenesis and network organization and dynamics of epileptic foci.
Marco de Curtis is Head of the Epilepsy Unit and of the Pre-clinical Neuroscience Laboratories at Fondazione Istituto Neurologico Carlo Besta in Milano, Italy. He is interested in function of neuronal networks in health and disease, with particular focus on epilepsy and ictogenesis
John G. R. Jefferys was until recently Professor of Neuroscience at the University of Birmingham, moving to the University of Oxford during the final stages of production of this volume. He received his BSc and PhD in Physiology from University College London and is a Fellow of the Academy of Medical Sciences. His research focuses on the emergent properties of neuronal networks and on the fundamental pathophysiology of focal epilepsy.

Table of Contents

- Modern Concepts of Focal Epileptic Networks - Neocortical Focus: Experimental View - Malformations of Cortical Development and Neocortical Focus - Limbic Networks and Epileptiform Synchronization: The View from the Experimental Side - Limbic Networks: Clinical Perspective - Modern Concepts of Seizure Modeling - Mechanisms of Ictogenesis - Seizure Termination - Epileptic Focus and Alteration of Metabolism - Modern Techniques of Epileptic Focus Localization - From Treatment to Cure: Stopping Seizures, Preventing Seizures, and Reducing Brain Propensity to Seize

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From the Publisher

Brings together cutting-edge research on modern concepts of the epileptic focus. Subject (latest observations about the pathophysiology of epilepsy, new insights into the cellular and network mechanisms of epilepsy and seizures obtained with novel and state-of-the-art research techniques). Authority of expertise of contributors (invited authors represent world leading experts in epilepsy research).